Real, who have not won the title since 2017, lead the table on 74 points, four ahead of Barca with five games left and have a superior head-to-head record over the Catalans which would give them the trophy if both teams finished the season level on points.
Chelsea won their first competitive match under coach Mauricio Pochettino with a 3-0 home victory over Premier League new boys Luton Town.
IMAGES from the football matches played across Europe on Sunday.
Champions Real Madrid were beaten at home by promoted Cadiz, while Barcelona fell to their first defeat in La Liga under new coach Ronald Koeman as they lost to Getafe.
A round-up of Sunday's matches in LaLiga, Ligue 1 and Serie A
Moffi penalty gives Lorient 1-0 win over Monaco.
Lionel Messi scored twice as Barcelona crushed Getafe 5-2 on Thursday to stay in the hunt for the La Liga title.
Real Madrid will be targeting a sixth consecutive victory since the COVID-19 hiatus when they host Getafe, looking to capitalise on Barca's 2-2 draw with Atletico Madrid on Tuesday
Karim Benzema and Vinicius Jr both scored a brace to give the LaLiga leaders a 4-1 home win over Valencia
Milan missed the chance to jump to second and remained fourth with 48 points
Sevilla last week lost a crucial game 1-0 at home to Valencia, who are fifth, but fared better this time as Mesa gave them the lead with an exquisite first-time finish into the far top corner in the 41st minute.
Images from matches played across European leagues on Saturday
Here are five talking points from the weekend in La Liga.
Luuk de Jong's first-half header gave Barcelona a 1-0 win at Mallorca
Atletico Madrid striker Alvaro Morata scored a goal and then missed a penalty as his side began their La Liga campaign with an eventful and nervy 1-0 win at home to Getafe on Sunday which saw both teams reduced to 10 men.
Manchester United breezed into the next round with a 6-1 aggregate win over Club Brugge
Four players from Italian side Sampdoria have tested positive for the novel coronavirus, including one for the second time, the Serie club said. Fiorentina said three players and three staff members tested positive while a day earlier Torino said one player had contracted the new coronavirus.
Having headed into the match tied on 47 league goals with West Ham's former stalwart Paolo Di Canio, Antonio was delighted to have surpassed the Italian as he celebrated by lifting a cardboard cut-out of himself at the side of the pitch.
Morata, who had scored his first goal for the club in last week's 2-0 win over Villarreal, rose to head home from close range on the half-hour mark following a corner which had been flicked on by Atleti captain Diego Godin.
An off-key Liverpool were frustrated for a second successive game by struggling opponents as they were held to a 0-0 Premier League draw at Newcastle United on Wednesday.
Real Madrid's stuttering season continued as they were reduced to 10 men and then slumped to an 11th La Liga defeat of the campaign by going down 3-1 at Real Sociedad.
Messi, who has struggled for form in recent weeks due to a niggling injury, looked on a mission to grab the winner and after twice coming close he completed his treble to put Barca ahead in the 85th minute, reacting quickly to a poor Sevilla clearance to dink the ball over goalkeeper Tomas Vaclik.
Here are five talking points from the weekend's La Liga action:
Internacional forward Paolo Guerrero missed a late penalty and then had a goal disallowed as his side were held 1-1 by Athletico Paranaense in Brazil's Serie A on Thursday.
Inter moved on to 68 points, ahead of Lazio on goal difference as the sides are level on their head-to-head records. They are eight points behind Juventus with six games to play.
Champions Barcelona lost 2-0 at Celta Vigo while Getafe earned an important 2-0 win over Girona in their bid to secure Champions League qualification.
It was Messi's 56th converted penalty in La Liga and saw him draw level with Hugo Sanchez as the league's second-top penalty taker, behind record holder Cristiano Ronaldo on 61.
Real Madrid's Thibaut Courtois, Federico Valverde, Eduardo Camavinga and Vinicius Jr have tested positive for COVID-19.
Griezmann special earns Atletico 1-1 draw at Sevilla
Gareth Bale injured himself in the warmup and was forced to wait for his Bernabeu debut but Real Madrid did not miss him as Cristiano Ronaldo scored twice in a 4-1 win over Getafe in La Liga on Sunday.
IMAGES from the soccer matches played in Spain and Italy on Saturday
Barcelona gave up more ground to Real Madrid in La Liga's title race on Tuesday after being held to a 2-2 draw at home to third-placed Atletico Madrid as a late penalty from Saul Niguez cancelled out Lionel Messi's 700th career goal. The draw meant the Catalans stayed second in the standings on 70 points and leaders Real Madrid, who have 71, will go four points clear at the top with five games left if they beat Getafe at home on Thursday.
UEFA said Eriksen, who was given CPR by medics on the pitch, was transferred to hospital where the 29-year-old was stabilised, with officials saying he was conscious. Following is a list of players who have collapsed on the pitch during a match.
Real Madrid coach Zinedine Zidane says Frenchman Karim Benzema is "distraught" about being left out of the squad for this year's European Championship, the only major tournament to be played in his home country during his career.
Real Madrid talisman Cristiano Ronaldo and Barcelona striker Luis Suarez took centre stage on Saturday in bailing their teams out with late strikes to silence their critics following slow starts to the season.
News of all that's transpired on and off the football field.
Atletico Madrid have recorded five COVID-19 positives, including manager Diego Simeone
Record signing Joao Felix scored two first-half goals for Atletico Madrid as they secured a 2-1 win over Juventus in the International Champions Cup.
Inter Milan midfielder Christian Eriksen scored his first goal for the club since last month's move from Tottenham Hotspur to set up a 2-0 win at Ludogorets Razgrad in their Europa League last 32, first leg on Thursday. Getafe pulled off a surprise 2-0 home win over last year's Champions League semi-finalists Ajax Amsterdam, while Manchester United were held 1-1 at Club Brugge in wet and windy conditions. Wolverhampton Wanderers' Diogo Jota scored a second successive hat-trick in the competition to lead his side to a 4-0 victory over Espanyol and Arsenal won 1-0 at Olympiakos Piraeus with a late Alexandre Lacazette goal.
Here are five talking points from the weekend in La Liga:
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