Setien was named Barcelona coach late on Monday, tasked with the job of restoring the club's iconic passing style, but the appointment represents a huge gamble for the Catalans given the 61-year-old's lack of success at the highest level.
Friday's win should add weight to the predictions of many that Spain are favourites to capture a third straight European title.
Aritz Aduriz's second half hat-trick sent Barcelona spinning to a shock 4-0 defeat at Athletic Bilbao in the first leg of the Spanish Super Cup on Friday.
Barca, who were without injured talisman Lionel Messi, started on the back foot and fell behind when Nabil Fekir netted with a sublime angled strike in the 15th minute. Griezmann, who joined Barca last month from rivals Atletico Madrid, scored four minutes before halftime to level the scores.
The new-look Davis Cup, masterminded by Barcelona footballer Gerard Pique, has the potential to rival golf's Ryder Cup as a sporting spectacle, the tennis competition's organisers say.
Real Madrid have enviously looked on as Barcelona claimed six La Liga titles in the last eight years, but Zinedine Zidane's side can take a huge step towards a first crown since 2012 with victory over their bitter rivals at the Nou Camp on Saturday.
Chelsea wrapped up their pre-season tour of the United States on a high note by beating Barcelona in a shootout after their International Champions Cup match ended 2-2 on Tuesday.
Barcelona defender Gerard Pique fears his side's shock elimination from the Champions League could disturb their bid to retain the La Liga title as they host Valencia on Sunday looking for a first win in four league games.
Coach Zinedine Zidane learned the lessons of predecessor Rafael Benitez's disastrous tactics in the last encounter and employed defensive midfielder Casemiro in favour of more attack-minded players, opting instead to sit and wait for Barcelona.
Serge Gnabry scored twice as Bayern Munich beat Chelsea 3-0, while Antoine Griezmann's second-half equaliser handed Barcelona a vital away goal and earned them a 1-1 draw at Napoli in their Champions League last 16, first leg on Tuesday.
Barcelona's hopes of staging another sensational Champions League comeback fell flat against a hardened Juventus side who held the Catalans to a 0-0 draw at the Nou Camp on Wednesday to reach the semi-finals 3-0 on aggregate.
Xavi brought his glittering Barcelona career to a fitting and emotional end when he hoisted aloft the European Cup following a 3-1 victory over Juventus in the Champions League final.
Lionel Messi created a goal and scored another as Barcelona came from behind to beat struggling Rayo Vallecano 3-1 at home on Saturday and stay seven points clear at the top of La Liga.
Barcelona are on the verge of Champions League elimination after being thrashed 3-0 by Juventus in Turin on Tuesday, and few believe lightning can strike twice.
A summary of sports events and persons who made news on Saturday.
Bayern Munich coach Pep Guardiola had predicted there was nothing he could do to contain the sublime talent of Lionel Messi during their Champions League semi-final against Barcelona on Wednesday -- and he was proved right.
News of all that's transpired on and off the football field
Proposals to revamp the Davis Cup into a season-ending 18-team event were backed by national federations at the International Tennis Federation annual general meeting in Orlando, Florida, on Thursday.
Images from football action around European leagues played on Sunday
Real Madrid coach Zinedine Zidane said he was disappointed that he was only asked about the referee's decisions after his side earned a 2-1 victory at Real Sociedad on Sunday to climb above Barcelona and top La Liga.
Real Madrid and Atletico each slipped 10 points behind La Liga leaders Barcelona after an intense Madrid derby finished goalless and the Catalans picked up an 11th victory in 12 games by winning 3-0 at Leganes.
Barcelona's Luis Suarez hit a brace and set up a double for a spritely Lionel Messi to score in his first start after injury in a rampant 6-1 Champions League victory over AS Roma on Tuesday.
'We were not lying yesterday when we said in the press conference Iran is a tough team'
Barcelona's poor run away to Real Sociedad continued when the champions were held to a 1-1 draw at Anoeta on Sunday and slipped six points behind La Liga leaders Real Madrid before next week's 'Clasico' against their arch rivals.
A summary of Wednesday night's action in the UEFA Champions League.
Here are five talking points from the weekend's action:
Real Madrid were dumped out of the Copa del Rey at the quarter-final stage on Thursday after losing 4-3 at home to Real Sociedad, while record 30-times winners Barcelona were sent crashing out of the Copa del Rey in a 1-0 defeat at Athletic Bilbao.
Cristiano Ronaldo scored a sensational goal and was then sent off for a combination of his provocative celebration and for diving as Real Madrid beat Barcelona 3-1 in an explosive Spanish Super Cup first leg on Sunday.
News of all that's transpired on and off the football field
AS Roma pulled off one of the great Champions League comebacks by knocking Barcelona out with a remarkable 3-0 win in their quarter-final second leg on Tuesday, overcoming a 4-1 deficit from the first game to reach the last four on away goals.
News of all that's transpired on and off the football field
A summary of sports events and sports persons, who made news on Thursday
Barcelona and Bayern fought hard but failed to break the shackles until the 77th minute in the match when Messi struck the first and three minutes later struck his 77th Champions League goal to double Barca's advantage.
Leaders Barcelona and Real Madrid were held to draws while Sevilla made up ground on the top two and Alaves slipped after a promising start. Here are five talking points from the weekend's La Liga action.
Lionel Messi struck a spectacular free kick, scored another goal and set up two more in a 4-1 victory for Barcelona over nine-man city rivals Espanyol in the first leg of their King's Cup last-16 clash on Wednesday.
Messi, who has struggled for form in recent weeks due to a niggling injury, looked on a mission to grab the winner and after twice coming close he completed his treble to put Barca ahead in the 85th minute, reacting quickly to a poor Sevilla clearance to dink the ball over goalkeeper Tomas Vaclik.
Lionel Messi scored a 50th freekick goal for Barcelona as he led his side to a quick-fire comeback to win 3-2 at Valencia on Sunday and keep the pressure on La Liga title rivals Atletico Madrid and Real Madrid.
Barcelona's 16-year-old forward Ansu Fati continued his explosive start to life in the first team by scoring and providing an assist as the La Liga champions thrashed Valencia 5-2 on Saturday.
AS Roma supporters may be looking ahead to Barcelona's Champions League visit with some trepidation and coach Rudi Garcia certainly does not seem to be bursting with optimism.
Barcelona take a 32-match unbeaten run to Arsenal for the first leg of their Champions League last 16 tie on Tuesday as the Catalans continue their bid to become the first team to retain the trophy in 26 years.