It was a tough night for Ronaldo in his 50th World Cup qualifier as he struck the base of the post in the 17th minute with a left-footed snapshot from just inside the penalty box, with the rebound falling perfectly for Bernardo Silva who inexplicably scuffed his effort wide.
Bayern Munich made it 16 wins from 16 games this season to underline their credentials as early Champions League favourites, beating holders Paris St Germain 2-1 away as Luis Diaz scored two goals and was shown a red card on Tuesday.
A round-up of Sunday's Nations League second leg quarter-final matches.
Dinamo Zagreb and Celtic played out a lifeless 0-0 draw in the Champions League on Tuesday, with Celtic keeper Kasper Schmeichel producing the match's memorable moment with a late save.
Sporting marked the final home game of coach Ruben Amorim's reign in stunning fashion as Viktor Gyokeres' hat-trick saw them come from behind to thrash Manchester City 4-1 and maintain their superb start to the Champions League on Tuesday.
Manchester City squandered a three-goal lead to draw 3-3 with Feyenoord in the Champions League on Tuesday.
IMAGES from UEFA Champions League matches played on Tuesday
There were, however, no eye-catching major deals in the final 24 hours of transfer activity for European clubs which continues the trend of recent January windows.
England forward Raheem Sterling joined Chelsea on a five-year contract from Manchester City, the two English Premier League clubs announced on Wednesday.
The Dutchman burst through the middle of the pitch and laid the ball off for Messi to dribble into the net for an 18th league goal of the season, extending his lead at the top of the scoring charts.
Images from Sunday's action in La Liga and Ligue 1.
Real Madrid captain Sergio Ramos once again proved to be the man for the big occasion as he converted a fiercely debated penalty to help his side to a 3-1 win over rivals Barcelona at an empty Camp Nou in La Liga on Saturday.
Images from the English Premier League matches played on Saturday.
Angel Correa saw La Liga leaders Atletico Madrid snatch a 2-1 victory away to Granada on Saturday
A round-up of Tuesday's action in the UEFA Champions League.
A round-up of Tuesday's action in the UEFA Champions League.
A round-up of Wednesday's action in the UEFA Champions League.
Images from Saturday's action in the English Premier League.
Lionel Messi was back in scoring business for Barcelona on Sunday, leading them to a resounding 4-0 win at home against Villarreal in a near-perfect La Liga opener for the Catalans under new coach Ronald Koeman.
News of all that transpired on and off the football field.
Juventus progressed to the Champions League last 16 after a Cristiano Ronaldo goal and a late header from substitute Alvaro Morata gave them a comeback 2-1 home win over Hungarians Ferencvaros on Tuesday.