Graham Potter is in talks to replace Lopetegui, according to British media reports, and the former Chelsea and Brighton & Hove Albion manager is expected to take charge of West Ham for their FA Cup third-round game at Aston Villa on Friday.
IMAGES from an exciting Europa League semi-final first leg match played at Emirates Stadium on Thursday
A summary of Sunday's action in the Premier League.
After a collective blow-out in the Champions League, England has a three-pronged attack on Europe's second tier competition with Chelsea, Tottenham Hotspur and Newcastle United all vying for Europa League success.
Javier Saviola and Oscar Cardozo scored two goals apiece and defender Luisao was also on target as Benfica thumped Everton 5-0 in the Europa League on Thursday.
Napoli put a foot in the Europa League semi-finals with a perfectly crafted 4-1 win at VfL Wolfsburg on Thursday as Marek Hamsik scored twice in an Italian masterclass to bring cheer to beleaguered coach Rafael Benitez.
United's Ibrahimovic, Roma's Dzeko find the net thrice to give clubs first leg advantage
IMAGES from the Europa League semifinal played between Manchester United and Sevilla in Cologne on Sunday.
Inter Milan and Bayer Leverkusen cruised into the Europa League knockout stage with emphatic wins on Thursday but holders Atletico Madrid and former winners Liverpool suffered surprise defeats.
The UEFA Cup will be renamed the UEFA Europa League from next season in an effort to boost the competition that has lost much of its appeal, European soccer's governing body said on Friday.
Paraguay striker Oscar Cardozo's well-taken double fired Benfica into a Europa League final with Chelsea after they beat Fenerbahce 3-1 in Lisbon to win their semi-final 3-2 on aggregate.
Images from the Europa League matches played across Europe on Thursday.
IMAGES from the Europa League matches played on Thursday
Triple European champions Manchester United and their under-fire coach Louis van Gaal face a tricky task against little-known Midtjylland in the last 32 of the Europa League following Monday's draw.
Heavyweights Arsenal, Atletico Madrid and Lazio took big steps towards reaching the Europa League semi-finals after convincing home first-leg victories and RB Leipzig also stayed on course with a 1-0 win over Olympique de Marseille on Thursday.
The Manchester clubs' wretched continental seasons ended on Thursday as outclassed United and battling City suffered contrasting Europa League last-16 exits to an exhilarating Athletic Bilbao and a fortunate Sporting respectively.
Kazakhstan's Astana fought back to beat a youthful Manchester United side 2-1 at home, Arsenal's woes continued as Frankfurt's Daichi Kamada scored twice to secure a 2-1 win.
United climbed to fourth in the standings on 15 points going into the last round of matches, in a strong position to reach the knockout phase along with Spurs who are sixth with 14 points.
United are 13th in the Premier League table and following a 1-1 draw with Dutch side Twente Enschede in the first Europa League match, Ten Hag said speculation about his job was inevitable.
Liverpool romed into the Europa League final with a 3-0 win over Villarreal on another magical night at Anfield to tee up a showpiece clash with holders Sevilla who swatted away visitors Shakhtar Donetsk 3-1 on Thursday.
Liverpool twice squandered the lead, trailed 3-2 and then scored three times in the last 25 minutes to win 5-3 at Young Boys in an enthralling but blunder-prone Europa League tie on Thursday.
It is the first time since 1989-90 that Manchester United have lost 10 of their first 22 games of the league season.
Atletico Madrid striker Antoine Griezmann struck twice as the Spanish side outclassed hapless Olympique de Marseille 3-0 on Wednesday to win the Europa League for the third time.
Athletic Bilbao, conquerors of Manchester United in the previous round, continued their Europa League run by scoring three times in the last 20 minutes to win their quarter-final first leg tie 4-2 at Schalke 04 on Thursday.
Tottenham have not won any silverware since they beat Chelsea in the 2008 League Cup final.
Arsenal and Chelsea were among seven teams to reach the Europa League knockout stage on Thursday, while last year's runners-up Olympique de Marseille were eliminated at the group phase.
Bruges scored four times in the last 17 minutes to beat Maribor 4-3 in the Europa League on Wednesday while Atletico Madrid and PAOK Salonika were among six teams to qualify for the knockout stage.
Liverpool resumed their march to a second Premier League title on Sunday with a 2-1 victory over West Ham United.
Liverpool and Ajax Amsterdam, who have won the European Cup nine times between them, failed to reach the quarter-finals of the Europa League after making embarrassing exits from the competition on Thursday.
Tottenham Hotspur could face punishment from European soccer's governing body UEFA after their Europa League game with Partizan Belgrade on Thursday was suspended for several minutes following three separate pitch invasions.
Aris Salonika maintained their 41-year unbeaten home record in European competition by holding Manchester City to a 0-0 draw in their Europa League last-32 first leg on Tuesday.
Benfica's Paraguay forward Oscar Cardozo converted two second-half penalties to help them come from behind and beat 10-man Liverpool 2-1 as the Europa League dished up more drama in the quarter-finals on Thursday.
Five-times European champions Liverpool suffered a 1-0 defeat at Lille after a late goal by forward Eden Hazard while Juventus beat underdogs Fulham 3-1 in Europa League last 16 first leg matches on Thursday.
Tottenham Hotspur's Europa League hopes were crushed by mid-table Belgian side Gent, who booked their spot in the last 16 with a 2-2 draw at Wembley on Thursday as the hosts paid the penalty for Dele Alli's first-half red card.
Carlos Bacca claimed the plaudits with a superb double strike, including a late winner to decide a pulsating clash that began at a hair-raising pace with four goals in the first half.
Reach fifth round for first time in 10 years
Seven-time European champions AC Milan will face Arsenal in the standout last-16 tie in the Europa League after the draw was made in Nyon, Switzerland on Friday.
Chelsea winger Eden Hazard will miss Wednesday's Europa League final against Benfica with a hamstring strain while John Terry's ankle problem is still being assessed, interim manager Rafa Benitez said.
Former Europa League winners Manchester United booked a quarter-final spot in the tournament after their second-string side laboured to a 2-1 home win over LASK Linz on Wednesday to seal a 7-1 aggregate rout of the Austrian side.
Bobby Zamora and Bjorn Helge Riise twice combined to set Fulham on their way to a 3-2 win at snowy Basel on Wednesday, sealing the London club's berth in the final 32 of the Europa League. Hertha Berlin, in last place in the Bundesliga, scraped through thanks to a 1-0 win at home to Group D winners Sporting and Panathinaikos of Greece secured second place in Group F when Djibril Cisse scored two in a 3-0 win over Dinamo Bucharest.