Leicester City face the latest challenge of Claudio Ranieri's remarkable managerial reign on Saturday, to come back down to earth from the high of a Champions League win for a domestic game against Burnley.
UEFA Cup holders Shakhtar Donetsk thrashed Club Bruges 4-1 away on Thursday when top-level football began experimenting with five-man refereeing teams in the opening Europa League group stage games.
Top two teams in each group qualify for the first knockout round. Third placed team to play in the UEFA Cup.
Leicester City striker Jamie Vardy has said the club will look to enjoy competing against Europe's elite in their Champions League debut. The English champions were drawn in Group G along with Porto, Club Bruges and FC Copenhagen in the Champions League after winning the English top-flight title for the first time in their history.
2004 Champions League finalists Monaco were eliminated 2-1 on aggregate by Swiss side Basel.
In other Champions League matches, Manchester United beat Scottish champions Rangers while Chelsea impressed while beating Lazio.
Costa, Alba excluded from Spain squad
Former European champions Ajax Amsterdam and Celtic, who both suffered the indignity of being knocked of the Champions League qualifiers by underdogs this season, will meet in the Europa Leagueafter being drawn together in the group stage on Friday.
The FIFA 2022 World Cup will kick-off in Qatar on Sunday, November 20. Here is a list of the 26-man squads playing in the quadrennial global football extravaganza.
Ajax, semi-finalists last season, came from behind to beat PAOK 3-2 for a 5-4 aggregate win over the Greeks while Red Star knocked out FC Copenhagen on penalties after a bizarre shootout involving 22 spot-kicks.
At the start of the season Leicester City fans could hardly have imagined their side would take the Champions League by storm.
Atletico Madrid were handed a chance to avenge last season's Champions League final defeat by city rivals and record 10-times winners Real after the two sides were drawn together in the last eight on Friday. Paris St Germain and Barcelona were paired together having met in the group stage, with the French side winning in Paris and the Catalans coming out on top in Spain.
"It is different to play midfield and striker but I enjoy all the positions I can play," the former Everton midfielder added.
Manchester United were given a troublesome tie against Club Bruges in the draw for the Champions League playoff round on Friday, although it could have been worse as they avoided Lazio, CSKA Moscow or Monaco.
Pep Guardiola will return to the Nou Camp in the Champions League group stage after his new club Manchester City were drawn against his former Barcelona team on Thursday. The two sides were drawn in Group C alongside Borussia Moenchengladbach and former European champions Celtic in one of the toughest of the eight sections. Spanish coach Guardiola, who won the Champions League twice with Barca, faced the Catalans when he was in charge of Bayern Munich two seasons ago and suffered a 5-3 defeat in the semi-finals.
News of all that's transpired on and off the football field
Iniesta has spent all of his senior career at Barcelona and is their most decorated player ever along with Lionel Messi, having lifted 31 trophies, which is soon to be 32 if Barca clinch the Liga title on Sunday at Deportivo La Coruna.
Manchester United have signed Leicester City's England centre back Harry Maguire on a six-year contract, the Manchester club announced on Monday.
Manchester United are feeling the pressure ahead of their Champions League qualifier against Club Bruges on Tuesday, according to manager Louis van Gaal.
News of all that's transpired on and off the football field
Last season's runners-up Liverpool, big-spending French league champions Paris St Germain and Carlo Ancelotti's Napoli were thrown together in the pick of the groups while holders Real Madrid must face last season's semi-finalists AS Roma.
Klopp has led Liverpool to back-to-back Champions League finals but is adamant that their impressive recent track record does not make them the title favourites.
Rattled by embarrassing domestic defeats, Chelsea looked jittery before Olivier Giroud settled their nerves with a close range tap-in shortly after halftime at StamfordBridge following good work by N'Golo Kante and Willian in the build-up.
Old Trafford rejoiced on Tuesday in anticipation of their next famous No. 7 after Dutch forward Memphis Depay scored two sublime goals to inspire Manchester United to a 3-1 victory over Club Bruges.
Romelu Lukaku scored twice to earn Belgium a 2-1 victory over Switzerland in the Nations League on Friday, lifting the mood in the country after a week marred by match-fixing allegations.
Leicester City has a chance to go top of the English Premier League table with a maximum nine points.
Images from the Champions League matches played on Tuesday
Galatasaray win 22nd Turkish title after beating closest rival
A summary of Tuesday's matches in the UEFA Champions League.
Since winning 2-1 at home to Wolfsburg in September, United have scored only twice in three Champions League games. In the Premier League the record is five goals in the last six games.
Manchester United ended their one-year Champions League hiatus in emphatic style when Wayne Rooney struck a hat-trick in a 4-0 destruction of Club Bruges that sent the three-times winners through 7-1 on aggregate on Wednesday.
On a night of close finishes in all five first-leg playoff games, the 21-year-old Dutch winger opened his United account with a memorable performance in the famous number seven shirt previously worn by George Best, Eric Cantona and David Beckham.
Eden Hazard finally scored his first goal for Real Madrid as his side beat second-placed Granada 4-2 in a highly entertaining game at the Santiago Bernabeu on Saturday to go four points clear at the top of La Liga.
News of all that's transpired on and off the football field
Napoli began their Europa League group stage campaign in scintillating fashion.
Last-minute starter Adrian Ramos scored a first-half header to give Borussia Dortmund a 1-0 victory over Sporting on Wednesday and earn a spot in the knockout stage of the Champions League with two Group F matches to spare.
Napoli put a foot in the Europa League semi-finals with a perfectly crafted 4-1 win at VfL Wolfsburg on Thursday as Marek Hamsik scored twice in an Italian masterclass to bring cheer to beleaguered coach Rafael Benitez.
Fiorentina tore apart Italian rivals AS Roma to reach the Europa League quarter-finals with a 3-0 win that left their opponents' season in tatters and under-fire coach Rudi Garcia tottering on the brink of the sack.