The Australian Open will lose one of its giant killers when South Korean Chung Hyeon meets American Tennys Sandgren in an unlikely quarter-final showdown at the Rod Laver Arena on Wednesday.
Switzerland's Stanislas Wawrinka rose to the occasion once again to beat Novak Djokovic with a scintillating display to win his first US Open and third Grand Slam title.
Djokovic had his personal best winning sequence of 30 consecutive sets ended as Cilic played almost flawlessly aggressive tennis to draw first blood in a magnificent duel.
The 'Big Four' has become a 'Big Three' with the shock exit of Rafael Nadal, and the remaining trio of Roger Federer, Andy Murray and Novak Djokovic will all be aiming to prove their elite credentials in Wednesday's quarter-finals.
World number one Novak Djokovic received a free pass into the third round of the U.S. Open when Jiri Vesely of the Czech Republic withdrew from their match on Wednesday due to a left forearm injury. The walkover provided the top-seeded defending champion with an extended break to improve his niggling left wrist injury before his next match against either Guido Pella of Argentina or Mikhail Youzhny of Russia.
It was the 31-year-old Serb's second comfortable win in the Gustavo Kuerten group and combined with Marin Cilic's 6-7(2), 6-3, 6-4 defeat of American John Isner later in the day, he sealed his place in the semi-finals at the year-ender for the eighth time.
Roger Federer made a comfortable start to his quest for a 100th title, despatching Fabio Fognini in straight sets to ease into the quarter-finals at the Paris Masters on Thursday.
Factbox on Andy Murray who won his second Grand Slam singles title at Wimbledon on Sunday by beating Serbia's Novak Djokovic 6-4 7-5 6-4 in the final.
Dhruv Munjal on why Novak Djokovic may yet win that highly contested title.
Gilles Simon will carry the distinction of being the first man to prise a set off Novak Djokovic at this year's Australian Open but the lion-hearted Frenchman was crushed after going down in a five-set classic on Sunday.
The Big Four were always going to come into the year's first Grand Slam knowing fully well that their days of dominance are drawing to a close, if not already a thing of the past, says Dhruv Munjal.
Canadian Milos Raonic will not be the only man experiencing something new on Wimbledon's Centre Court on Sunday -- for the first time Britain's Andy Murray will start a Grand Slam final as favourite after crushing Tomas Berdych in the semis.
Stefanos Tsitsipas pulled off one of the biggest wins of his short but remarkable career by beating Rafael Nadal 6-4 2-6 6-3 on Spanish soil on Saturday to book his place in the Madrid Open final against world number one Novak Djokovic.
Second Andy Murray breezed to a 6-3, 6-0 semi-final victory over Kei Nishikori on Saturday to set up a final with Novak Djokovic at the Rogers Cup in Montreal.
Britain's Andy Murray overcame a blistering start from Tomas Berdych to advance to his fourth Australian Open final with a 6-7(6), 6-0, 6-3, 7-5 victory on Thursday.
Four more performances like that at the O2 Arena this week should guarantee Andy Murray will end 2016 leading the pack.
World number one Novak Djokovic has enjoyed a whirlwind trip to Sunday's U.S. Open final, but the top-seeded Serb expects hard work ahead when he meets Stan Wawrinka at Arthur Ashe Stadium. Defending champion Djokovic, who became the third man to hold all four grand slam singles titles at once after his triumph at Roland Garros in June, owns a 19-4 career head-to-head advantage over the Swiss third seed.
Check out some of the up-and-comers who could cause an upset at Wimbledon this year.
Novak Djokovic joined the tennis greats on Sunday when he downed British second seed Andy Murray 3-6 6-1 6-2 6-4 to claim his maiden French Open title and hold all four grand slams at the same time. The world number one recovered from a nervous start to impose his pace on Court Philippe Chatrier and clinch his 12th grand slam crown after three previous failures in a Roland Garros final. Djokovic is only the third man after Don Budge and Rod Laver to hold the four majors at the same time, and the eighth man to triumph at Wimbledon and the French, U.S. and Australian Opens.
Novak Djokovic is fallible after all, as American powerhouse Sam Querrey proved in stunning fashion to stop the Serb's seemingly unstoppable charge towards a calendar year grand slam at a rain-hit Wimbledon on Saturday. The 28th seed boomed down 31 aces and repelled an attempted Djokovic comeback to win a third-round match that began the previous evening 7-6(6) 6-1 3-6 7-6(5).
Defending champion Novak Djokovic's preparations for Wimbledon have been laid back in the extreme.
Novak Djokovic had to fight back from a set down to beat Thomaz Bellucci and reach the Italian Open quarter-finals.
Defending champion Serena Williams is the top seed in the women's draw. The American will be looking to equal Steffi Graf's Open era record by sealing a 22nd Grand Slam triumph.
List of men's singles champions at Wimbledon:
Roger Federer subdued Tomas Berdych 3-6, 6-4, 6-3 in the final to win the Dubai Championship on Saturday, the Swiss maestro's 78th singles title.
Seven years after their first Grand Slam final meeting, Novak Djokovic and Roger Federer stand on the verge of a third showdown at the highest level.
Former world number one Caroline Wozniacki eased into the semi-finals of the US Open on Tuesday with a ruthless 6-0, 6-2 win over wounded Latvian Anastasija Sevastova.
Novak Djokovic and Roger Federer remain on course for a marquee one-two clash in the men's US Open final, but each must first vanquish a formidable opponent and friend in Friday's semi-finals at Flushing Meadows.
Novak Djokovic vanquished Andy Murray for the fourth time in an Australian Open final on Sunday to win a record-equalling sixth title and serve notice to his rivals that he could surpass even his stellar 2015 this year.
Factbox on Serbia's Novak Djokovic and Great Britain's Andy Murray who will contest his sixth Australian Open men's singles final on Sunday.
Britain's Andy Murray won lifted his second Wimbledon title after defeating Canadian Milos Raonic 6-4 7-6(3) 7-6(2) on Sunday. Following that clinical performance, here is a list of Wimbledon men's singles champions since 1922....
Images from Wednesday's matches at Roland Garros
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