This is Sindhu's third consecutive first round loss.
Sankar Muthusamy Subramanian caused a major upset by knocking out World No 2 Anders Antonsen of Denmark in a thrilling three-game contest to reach the men's singles quarter-finals.
Kidambi Srikanth is the lone Indian survivor at the Swiss Open Super 300 badminton tournament in Basel. He progressed to the semi-finals with a straight-games win over Chinese Taipei's Chia Hao Lee on Friday night.
With both their singles and doubles challengers crashing out in the opening round itself, India's campaign came to a disappointing end in the Swiss Open Super Series badminton tournament in St Jakobshalle, Switzerland.
The Wimbledon champion was dumped by the world No. 47 in the second round of the Swiss Indoors.
Top seed Kidambi Srikanth stormed into the semi-finals of the US $120,000 Swiss Grand Prix Gold badminton championship after a straight games victory over Takuma Ueda of Japan in the men's singles quarter-finals in Basel on Friday. The Indian beat the eighth seed 21-11, 21-12 in 31 minutes.
Parupalli Kashyap entered the quarterfinals after top seed and Olympic champion Axelsen gave a walkover.
The 29-year-old Spaniard, who needed a final-set tiebreak to fight past Lukas Rosol in the first round, produced a performance of defiant persistence to fend off the challenge of the 24-year-old Dimitrov.
Roger Federer claimed an eighth Swiss Indoor title when he outlasted Argentina's Juan Martin del Potro 6-7(5), 6-4, 6-3 in front of a partisan Basel crowd on Sunday.
Two-time champion and top seed Saina Nehwal and P V Sindhu reached the pre-quarterfinals of the $ 120,000 Swiss Open Grand Prix Gold in Basel.
Kidambi Srikanth entered the final of the $120,000 Swiss Grand Prix Gold badminton championship after he got the better of compatriot Ajay Jayaram in an all-India last-four clash in Basel on Saturday.
PV Sindhu won Swiss Open title after beating Busanan Ongbamrungphan of Thailand in final
India's Kidambi Srikanth clinched the Swiss Grand Prix Gold badminton championship title after overcoming a strong challenge from Viktor Alexson in a hard-fought men's singles final in Basel on Sunday.
Stan Wawrinka outlasted Frances Tiafoe over three sets to set up an all-home quarter-final against compatriot and fellow veteran Roger Federer at the Swiss Indoors on Thursday. The 34-year-old Waewrinka, who won 6-3, 3-6, 7-5, will attempt to beat Federer for only the fourth time when they meet for their 27th clash on Friday in a dream tie for the Basel crowd.
India's champion shuttler P V Sindhu feels more women will win medals for the country in future and hard work is the key to success.
P V Sindhu will be eager to return to the podium as former winner Saina Nehwal looks to regain her touch
As the Indian national anthem reverberated across the St Jakobshalle stadium, Sindhu stood at the podium with moist eyes.