Second half goals from Presnel Kimpembe and Kylian Mbappe gave the impressive French side a clear advantage ahead of the return in Paris on March 6.
In Pep Guardiola's 100th match in charge of the Manchester club, captain De Bruyne led from the front as City outclassed the Gunners, who have now suffered six home games without a win. Images from the EPL matches played on Sunday.
'I would have liked to have scored against another team but that's life'
Real Madrid star striker Cristiano Ronaldo scored thrice to help his side thrash Espanyol 6-0 in a ruthless attacking display in La Liga clash at Santiago Bernabeu.
David Zurutuza struck twice to help Real Sociedad seal a remarkable comeback and beat Real Madrid 4-2 in La Liga.
News of all that's transpired on and off the football field
Cristiano Ronaldo's fifth Champions League hat-trick inspired Real Madrid to a 3-0 comeback victory over VfL Wolfsburg on Tuesday that clinched a place in the semi-finals for a sixth successive season.
France ended Nigeria's hopes of a first World Cup quarter-final appearance when they scored two late goals to beat the Super Eagles 2-0 in a rough second-round match on Monday.
Now, Real Madrid have never won the Spanish treble and are fighting tooth and nail in La Liga to prevent arch-rivals Barcelona scooping Champions League and domestic league and Cup titles for a second time.
A summary of Thursday's Euro 2020 qualifying matches.
Barcelona thrashed Sporting Gijon 6-1 to go top of La Liga on a dramatic night in Spain on Wednesday as Luis Enrique announced he was stepping down as the Catalan club's coach at the end of the season.
Following Bayern Munich's brilliant 7-4 (on aggregate) win over FC Porto in the quarter-finals of the Champions League, here's a look at a few memorable come-from-behind victories in Europe's premier football competition.
The injury list in the La Liga keeps growing as the season progresses and this time Lionel Messi and Gareth Bale are the unfortunate victims...
A late goal by Toni Kroos sealed victory as Real Madrid defeated an impressive Celta Vigo side 2-1 to win their first home La Liga game of the campaign on Saturday.
Atletico Madrid's Jackson Martinez scored his first goal for the club when he came off the bench and curled in a superb effort to seal a hard-fought 3-0 victory at Sevilla in La Liga on Sunday.
Second division Mirandes caused an upset by knocking Deportivo La Coruna out of the King's Cup on Tuesday and Sevilla joined them in the quarter-finals after making light work of city rivals Real Betis.
News of all that's transpired on and off the football field
Real Madrid's 5-0 thrashing of Granada on Saturday equalled a Spanish record of 39 games unbeaten in all competitions. Reuters Sport takes a look at the factors behind their run.
'We are on anti-terrorist alert four (with five a very high risk) and there will be extensive security so as to guarantee that the match takes place with complete normality'
Griezmann special earns Atletico 1-1 draw at Sevilla
News of all that's transpired on and off the football field
Wednesday night saw a few surprise results while a debutant club makes a mark
Champions Barcelona suffered their second defeat in three matches in La Liga on Saturday, with Michael Krohn-Dehli scoring and setting up another goal in a 2-1 victory for Sevilla.
Real Madrid paid more than 200 million euros ($227.76 million) to assemble their forward line of Cristiano Ronaldo, Gareth Bale and Karim Benzema, but the attacking trio failed them again in Wednesday's Champions League exit to Juventus.
While Lyon rallied to hold Leipzig 2-2 after a Memphis Depay strike, it was the English clubs who made a mark on the night. Liverpool and Chelsea moved into the last 16 with contrasting wins and now all four English clubs, including Manchester City and Tottenham Hotspur, are in the Champions League knockouts this season.
An all-conquering Spain side were on the crest of a wave last time they faced Germany on the way to winning the 2010 World Cup but they now meet on Tuesday in what will be a stern test for a new fledgling team.
Bastia game abandoned after fans attack Lyon players
Real Madrid maintained their pursuit for the title by defeating Malaga 3-1 late on Saturday.
Real Madrid reached their 14th European Cup final and crushed Manchester City's hopes of a maiden title after Gareth Bale's deflected effort secured a 1-0 victory in the second leg of their Champions League last four clash on Wednesday.
Holders Real Madrid survived a huge scare when they lost 4-3 to Schalke 04 in the Champions League on Tuesday but squeezed into the quarter-finals 5-4 on aggregate thanks to record European marksman Cristiano Ronaldo.
United's Ibrahimovic, Roma's Dzeko find the net thrice to give clubs first leg advantage
In the other match of the night, Jamaica 'keeper blunder hands Paraguay 1-0 win
A summary of Friday's Euro 2020 qualifying matches.
Atletico Madrid maintained a two-point lead in La Liga with a 3-0 victory at Las Palmas and Barcelona and Real Madrid stayed hard on their heels with thumping wins over Athletic Bilbao and Sporting Gijon on Sunday.
Bayern Munich are on a mission with coach Pep Guardiola firing up his injury-hit team as they seek to reverse a 3-1 deficit against Porto in the Champions League quarter-final second leg on Tuesday.
Real Madrid's trophy aspirations could well depend on how well they cope with an injury crisis that sees Gareth Bale and Luka Modric in the treatment room.
Barcelona followed up Saturday's win over Real Madrid with another victory when Alexis Sanchez set the champions on their way to a 3-0 success at Celta Vigo on Tuesday that put them four points clear at the top of La Liga.
A round of Wednesday night's Champions League group stage matches.
News of all that's transpired on and off the football field
African football hit dizzying heights before descending into violent farce