Tottenham Hotspur showed the English Premier League title race might not be just a two-horse affair with a hugely impressive 6-2 win at Everton.
A summary of Sunday's Premier League matches
A late goal by substitute Charlie Austin gave relegation-threatened Southampton a thrilling 3-2 victory over Arsenal on Sunday in new Austrian manager Ralph Hasenhuettl's first home game.
Juergen Klopp's side, chasing their maiden title in the Premier League era and first in the top flight in 30 years, took a 14th-minute lead from a Virgil van Dijk header but had to wait until stoppage time to put the game to bed through Mohamed Salah.
The result leaves Ole Gunnar Solskjaer's United in 10th with nine points, their worst start after seven games for 30 years, and they have won just one of their last six league games.
IMAGES from the English Premier League matches played on Saturday.
Images from the English Premier League matches played on Saturday.
Arsenal's Aubameyang compared to Henry after his derby double
The Argentine scores a hat-trick to become the highest foreign goal scorer in the Premier League on Sunday. Also, in bagging a 12th Premier League hat-trick he surpassed the 11 of Alan Shearer with whom he had shared the record.
Guardiola says City's points record may last years
Following are facts and figures after Manchester City clinched the Premier League title
The injury to the Chile forward, who was left out of the squad for Tuesday's Champions League victory over Young Boys, "will require further investigation to confirm its severity", the club added.
Mohamed Salah is ready to feature in Liverpool's Premier League title decider against Wolverhampton Wanderers on Sunday after the Egyptian forward recovered from concussion.
As per the agreement, Nissan Motor India 'can enjoy concessions in the wharfage up to 60,000 units per annum.'
A summary of Sunday's Premier League matches.
In a gripping title race, Liverpool showed they are ready to push Manchester City right until the final seconds of this season with their spirited 3-2 win at Newcastle United.
Liverpool had won each of their previous four home leagues games in which they conceded first and 12 minutes later they had turned another match on its head as Roberto Firmino's trickery set up Mane to give the hosts the lead at the second attempt.
Arsenal coach Arteta has said that Granit Xhaka will stay at the London club while United have new headaches with injuries to Paul Pogba and Scott McTominay.
City are looking to retain the title they won in record-breaking fashion last year and secure their fourth Premier League crown in eight years.
Liverpool regained their place at the top of the English Premier League with a 2-0 win at Cardiff City on Sunday that restored their two-point lead over Manchester City
Wilfred Ndidi netted a dramatic late equaliser on Saturday to help Leicester City secure a 1-1 draw with West Ham United, who played more than half the game with 10 men after Mark Noble was shown a straight red card.
The two previous meetings at Anfield ended in 4-0 and 3-1 defeats for Arsene Wenger's Arsenal teams, but there is a fresh optimism around the club after a successful transfer window.
Whatever happens, there will be no shortage of drama between now and May 12.
IMAGES from the English Premier League matches played on Wednesday
IMAGES from the English Premier League matches played on Sunday
Raheem Sterling scored a hat-trick as champions Manchester City made a convincing start to their title defence with a 5-0 win over West Ham United.
Klopp says Liverpool's defending to blame for loss
Zlatan Ibrahimovic was back to his irrepressible, boastful best on Sunday as he joked about the landmark 25,000th Premier League goal that signalled a change in his fortunes.
An own goal by Stoke City keeper Jack Butland gifted Leicester City an equaliser in a 1-1 Premier League draw at the King Power Stadium on Saturday and denied Paul Lambert's side a rare win on the road.
Chelsea may still take their case to the Court of Arbitration for Sport, as other clubs have done in the past.
Following is a match by match look at the English Premier League's season-opening weekend fixtures:
Liverpool manager Juergen Klopp has dismissed claims that it is the perfect time to face Tottenham Hotspur because of injuries to key players and concern over striker Harry Kane's form and freshness.
Strong start bodes well for Spurs' title hopes, says Lee
Goals from Rodri and Kevin De Bruyne secured a comfortable win at the Etihad
Title-chasing Tottenham Hotspur made hay in the sunshine as Son Heung-min scored twice in a 4-0 thrashing of Watford that closed the gap on Premier League leaders Chelsea to four points in Saturday's early kickoff.
Images from the EPL matches played on Saturday
'It's like now with Lamela or Vertonghen, how you sit in the chair and cry because you miss someone... But the competition does not allow you to cry. You have to move on quick. It's a bit cruel, but you have to move on and try to win the next game'
Tottenham Hotspur's exhilarating Premier League title surge came to a shuddering halt as they lost 1-0 at West Ham United on Friday to leave Chelsea needing six points from four games to be crowned champions.
But for third-placed Spurs, who trail leaders Manchester City and Liverpool by five points, this may prove to be a loss that leaves them with too much ground to make up.
But it was not all good news for Mourinho, as substitute Marcus Rashford was sent off in the 71st minute for pushing his forehead into Phil Bardsley's head.