Travis Head hammered a solid ton at the Oval as Australia dominated the proceedings over India on Day 1 of the WTC Final.
After left-armer Afridi's two early wickets, Australia could have been in even deeper trouble but Pakistan failed to capitalise on chances offered by Khawaja and Smith.
The Indian team, set to play the second Test against Australia from Friday, had to switch hotels in New Delhi.
Images from Day 2 in the fifth Test between Australia and England, in Hobart, on Saturday.
In a setback for England, Moeen Ali was penalised for applying spray on his finger towards the end of day two.
Ravichandran Ashwin's superlative show in the fourth Test against Australia has helped him regain the top spot among bowlers in the latest ICC Rankings.
Australia bundled out Sri Lanka for 212 but endured a top order wobble of their own before reaching 98/3 in reply after a frenetic, spin-dominated day one of the opening Test in Galle on Wednesday.
Siraj was perhaps the only bright spot for India with the ball
Travis Head's counter-attacking hundred and his unbroken 251-run stand with Steve Smith put Australia in charge on 327/3 on the opening day of the WTC final against India.
Khawaja said he was still good with bat in his hand and that "age is just a number".
Marnus Labuschagne said Australia, especially the pacers, did not even bring their "B Game" in the win against England in the Ashes opener.
Former Australia skipper Ricky Ponting said that England batter Joe Root is fulfilling his full potential with his run over two years.
Australia, on their first tour of Pakistan in 24 years, finished day three 205 behind but scored freely after resuming on five for no loss.
Nathan Lyon said there was enough recovery time for Warner before the third Test beginning on March 1.
Australia's two-time World Cup winning captain Ricky Ponting says senior batsman Usman Khawaja was axed from the national team due to his inconsistency but he is not willing to write him off yet. The 33-year-old Khawaja was recently left out of the Australia's annual list of contracted players after he was dropped midway through last year's Ashes.
Out-of-favour opener Usman Khawaja, who clashed with Justin Langer during Australia's tour of UAE in 2018, has backed the embattled coach to continue in the position through the Ashes and urged the payers to stop undermining him.
India have recalled Ajinkya Rahane to reinforce their batting line-up, which will have to be at its best to negate the Australian attack.
Smith said England's batters may not fare so well against the Australian bowling attack
Marnus Labuschagne was bowled off an inside edge but Ravindra Jadeja had overstepped, before India erred by not opting for a DRS against the Australian right-hander.
Australia's Steve Smith struck a superb 144 on his return to the side as they recovered from 122-8 to reach 284 all out against England in the first innings of the first Ashes Test before the hosts saw out two overs unscathed at Edgbaston on Thursday.
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Steve Smith was on 59 unbeaten with Labuschagne at the close.
Australia have kept their bowling options wide open for India tour
Warner's participation was considered doubtful for the next red-ball assignments for Australia, especially after his horrendous run in India with the bat.
Captain Pat Cummins said after the match that Hazlewood's injury was nothing too serious.
'I'll definitely talk to the likes of Usman Khawaja and Joe Burns to get a gauge of (the Pakistani bowlers') skills and the way they go about their games'.
'There's going to be a lot of logistics involved given the IPL final is only a week before the WTC final'
'Kuhnemann put his hand up straight away and did a fantastic job'
India are chasing a victory in Ahmedabad to confirm their place in the final of the World Test Championship against Australia in June.
Ravichandran Ashwin becomes leading wicket-taker in Border-Gavaskar Trophy history
Green made a bigger impact in the ongoing contest in Ahmedabad where he smashed 114, only the third century in the bowler-dominated series.
Images from Day 3 of the second Test between Australia and South Africa at the Melbourne Cricket Ground on Wednesday.
Poor batting was at the heart of the debacle.
As the prestigious Ashes gets underway, here's a look at the milestones that can be achieved.
Travis Head, D' Arcy Short and Chris Lynn have been dropped, while the pace trio of Mitchell Starc, Pat Cummins and Josh Hazlewood have been rested.
The hosts then raced to 199-6 in 31 overs, effectively batting West Indies out of the contest, before declaring their second innings.
The 31-year-old was out of action since undergoing a surgery on a torn meniscus which he had sustained during their Test series against Pakistan in October in the UAE.
Ravichandran Ashwin is fast closing in on the No 1 spot in the ICC Test rankings for bowlers.