English Premier League leaders Liverpool will need to maintain their excellent recent record against Everton in Sunday's Merseyside derby if they are to hold their advantage over second-placed Manchester City.
Manchester City's Premier League title defence fell apart at the seams in a 3-1 defeat to Southampton on Saturday when goalkeeper Joe Hart committed a howler and Gareth Barry scored a bizarre own goal.
Chelsea surrendered another three points in their quest for a top-four Premier League finish as Newcastle United's new signing Moussa Sissoko struck in the last minute to grab a 3-2 win that left Rafa Benitez's side reeling.
Third-tier Oldham Athletic stunned seven-times FA Cup winners Liverpool with a shock 3-2 fourth-round win on Sunday and Leeds United caused another big upset by knocking out Tottenham Hotspur 2-1 at Elland Road.
Newcastle United's Papiss Cisse has gatecrashed the Premier League in spectacular style and his second strike in Wednesday's win at Chelsea could sneak in as a goal of the season contender, especially given its potential importance.
Images from the English Premier League matches played on Sunday
Lazio have been handed a suspended one-game stadium ban by UEFA following anti-semitic chanting by home fans in a Europa League game against Tottenham Hotspur in November, Italian media reported on Friday.
Roy Hodgson became the leading contender to take charge of England at Euro 2012 when the English FA said they had spoken to the West Bromwich Albion manager about succeeding Fabio Capello.
Gareth Bale had a bitter-sweet start to his Real Madrid career when the world's most expensive player scored on debut but Real dropped their first points of the La Liga campaign in a 2-2 draw at promoted Villarreal on Saturday.
Chelsea enjoyed some much-needed home comfort with goals from Juan Mata and Frank Lampard securing a 2-1 victory over Arsenal in the Premier League on Sunday.
Manchester United missed the chance to make significant inroads into Manchester City's lead at the top of the Premier League after stumbling to a 1-1 draw against Newcastle United at Old Trafford on Saturday.
Manchester City seized the chance to put Premier League leaders Manchester United under pressure with David Silva's double in a 2-0 victory over Fulham on Saturday while Liverpool recorded a 5-0 win at home to Norwich City.
Tottenham Hotspur manager Andre Villas-Boas has admitted he made mistakes at Chelsea and that they were right to dismiss him after less than nine months in charge.
'It's not like that. It's more complicated. With Bale it's always about one side against the other. But I've never had a problem with Gareth.'
Queens Park Rangers manager Harry Redknapp had to be content with a point in his first game against former club Tottenham Hotspur on Saturday with a 0-0 draw at Loftus Road lifting the strugglers off the foot of the Premier League.
United States forward Clint Dempsey completed a shock move from Fulham to London rivals Tottenham Hotspur for an undisclosed fee.
Skipper John Terry and left back Ashley Cole are both available for Chelsea's FA Cup semi-final against Tottenham Hotspur at Wembley this weekend after recovering from injuries, stand-in manager Roberto Di Matteo said on Friday.
Chelsea defender Branislav Ivanovic will miss Sunday's FA Cup semi-final against Tottenham Hotspur at Wembley after being handed a three-match ban by the Football Association (FA).
Bolton Wanderers midfielder Fabrice Muamba has tweeted a picture of himself in his hospital bed two weeks after suffering a cardiac arrest during his side's FA Cup quarter-final against Tottenham Hotspur.
Tottenham Hotspur scored three late goals to beat Bolton Wanderers on Tuesday and set up an FA Cup semi-final against Chelsea, after replaying the game that was abandoned when midfielder Fabrice Muamba suffered a cardiac arrest on the pitch.
A student who mocked footballer Fabrice Muamba on Twitter after the Bolton Wanderers midfielder collapsed during a match was jailed on Tuesday for inciting racial hatred.
The 56-year-old Portuguese returns to management for the first time since being sacked by Manchester United in December, and replaces Mauricio Pochettino, who was sacked on Tuesday.
Bolton Wanderers midfielder Fabrice Muamba remained in a critical condition after suffering a cardiac arrest during the FA Cup quarter-final at Tottenham Hotspur on Saturday, the hospital and club said in a joint statement on Sunday.
Images from the English Premier League matches played across England on Sunday.
Belgium international Jan Vertonghen scored a second-half winner to send Tottenham Hotspur back into the top four of the Premier League after a 1-0 home win against a stubborn Swansea City on Sunday.
Chelsea moved within three points of clinching the Premier League title with a 3-0 victory that condemned Middlesbrough to relegation on Monday after goals from Spaniards Diego Costa and Marcos Alonso plus a tap-in by Nemanja Matic.
Third-placed Tottenham Hotspur are peering anxiously over their shoulders after a 1-0 Premier League loss at Everton on Saturday continued a slump in form while Chelsea beat Stoke City by the same scoreline to keep the pressure on their London rivals.
Liverpool dominated the Premier League last season, winning their first domestic league title for 30 years
Manchester United can stamp out any lingering Tottenham Hotspur title ambitions with a victory in London this weekend that would set the Premier League trophy firmly on course to remain in northwest England.
Tottenham Hotspur's injury-plagued defender Ledley King announced his retirement from the game on Thursday.
Manchester United will be without world record signing Paul Pogba for their Premier League opener against Bournemouth on Sunday due to a suspension, the Football Association said on Friday.
Lazio's Alvaro Gonzalez, Mirolsav Klose and Hernanes secured a 3-0 victory over Udinese in Serie A on Tuesday at the Stadio Olimpico where the home fans sang racist chants aimed at rivals Roma who share the stadium.
Ten supporters of English soccer club Tottenham Hotspur were injured, one of them seriously, during an attack in Rome in the early hours of Thursday ahead of a Europa League match against Serie A side Lazio, police said.
Arsenal are buzzing after their resounding victory over north London rivals Tottenham Hotspur but they go into Wednesday's Champions League home clash with Montpellier aware that any slip could be costly to their last 16 hopes.
Striker Clint Dempsey was named US Soccer's 'Athlete of the Year' for 2012, winning the award for the third time and second in a row, the federation said on Monday.
Tottenham Hotspur's Emmanuel Adebayor, sent off after 17 minutes of the north London derby on Saturday, has apologised for the red card that turned the match Arsenal's way but says there was no malice in his challenge on Santi Cazorla.
Manchester United defender Rio Ferdinand will miss the Premier League champions' opening Champions League Group C match against Benfica in Lisbon on Wednesday, the club said on Tuesday.
After the verdict, Harry Redknapp, one of the best known figures in English soccer, said the strain of the investigation had been "horrendous" as he fought back tears.
Images from Sunday's action in the Premier League.
France's World Cup-winning captain Hugo Lloris has been banned from driving for 20 months and fined after pleading guilty to a charge of drink driving, British media reported on Wednesday.