Cristiano Ronaldo missed a penalty as Real Madrid and neighbours Atletico were held to draws leaving Barcelona with an eight-point lead at the top of La Liga and 13 matches left.
Barcelona coach Ernesto Valverde will be banking on new signing Ousmane Dembele to fill the gap left by Neymar's departure as he looks to overcome off-pitch difficulties when the Catalans take on Espanyol on Saturday.
Here, Reuters Sport highlights five reasons why last season's double winners have collapsed.
A summary of Saturday's action in Ligue 1, La Liga and Serie A.
Real Madrid captain Sergio Ramos risks being hit with an extra game suspension which would rule him out of a potential Champions League quarter-final first leg after admitting he got booked on purpose in Wednesday's 2-1 win at Ajax Amsterdam.
News of all that's transpired on and off the football field
Luis Enrique's new task is to rebuild a Spain team that ruled international football between 2008 and 2012 by winning successive European Championships and the 2010 World Cup but have been deeply disappointing at their last three international tournaments.
Misfiring Real Madrid need quick response ahead of Barcelona visit.
Portugal had to settle for a 0-0 draw at home to Spain in a heavyweight friendly on Wednesday after hammering the crossbar twice and missing a last-gasp open goal.
Real Madrid coach Rafa Benitez has been relying on second-string players to get the club through a mini injury crisis but should have several of his heavyweights back when Paris St Germain visit in the Champions League on Tuesday.
IMAGES from the Euro 2020 qualifiers
Spain squeezed past dogged Iran 1-0 in their World Cup Group B encounter on Wednesday, thanks to a fortuitous goal from Diego Costa, but the Europeans suffered a string of second-half scares.
The World Cup has seen the most talented footballers on the planet. The tournament is also home to the glamorous wives and girlfriends (WAGs) of these players.
Real Madrid coach Zinedine Zidane said he was disappointed that he was only asked about the referee's decisions after his side earned a 2-1 victory at Real Sociedad on Sunday to climb above Barcelona and top La Liga.
Cristiano Ronaldo may have played his last game for Real Madrid after winning a fourth Champions League crown with the Spanish side in a 3-1 victory over Liverpool on Saturday, saying he would soon make an announcement on his future.
Real Madrid put their title defence back on track with a comfortable 3-1 win over Real Sociedad at Anoeta on Sunday, despite missing several key players. Sociedad defender Kevin Rodrigues scored at both ends and Borja Mayoral and Gareth Bale netted Madrid's other goals to help them equal the consecutive scoring record of 73 games set by Pele's Santos between 1961 and 1963.
Lopetegui blends youth and experience in Spain World Cup squad
Holders Real Madrid reached the Champions League final for a third year in a row after taking advantage of Bayern Munich's carelessness in attack and defence to draw 2-2 in their semi-final second leg on Tuesday, and winning 4-3 on aggregate, at the Santiago Bernabeu, in Madrid, Spain, on Tuesday.
News of all that's transpired on and off the football field
Unai Emery's Villarreal were much improved in the second half and had spurned numerous chances before Moreno's leveller.
Cristiano Ronaldo and Lionel Messi will again be duelling for the title of world's best footballer after their names once again headed the shortlist on Thursday for The Best FIFA Men's Player.
Cristiano Ronaldo showed nerves of steel to score an injury-time penalty and send holders Real Madrid into the semi-finals of the Champions League in extraordinary circumstances as they lost 3-1 to Juventus on Wednesday but won a thrilling tie 4-3 on aggregate.
News of all that's transpired on and off the football field
Real Madrid beat Manchester United 2-1 on Tuesday to lift the European Super Cup for the fourth time as they became the first team to retain the trophy since AC Milan in 1990.
Cesc Fabregas struck the winner as an experimental Spain side came from behind to beat Costa Rica 2-1.
An estimated 10,000 Napoli supporters, including the team's most famous player Diego Maradona, are expected to make the trip to the Spanish capital for the first competitive meeting with Real Madrid since the 1987.
Coach Diego Simeone goes home 'content' after his team's 1-0 loss in their Champions League match on Wednesday
Real Madrid defender Nacho was the unlikely hero as they snatched a 1-0 win at Real Valladolid on Sunday to capitalise on Barcelona's defeat at Valencia this weekend and move three points clear of their rivals at the top of La Liga. Serie A leaders Juventus suffered a shock 2-1 defeat at Napoli on Sunday, with coach Maurizio Sarri returning to his former club for the first time, though Cristiano Ronaldo still managed to score for an eighth league game in a row for the visitors.
James Rodriguez headed the opener before going off injured in Real Madrid's win.
Atletico aim for Champions League revenge against Real at fourth attempt.
Real Madrid's faltering title defence continued as they were held to a thrilling 2-2 draw at Celta Vigo on Sunday which saw them fall 16 points behind runaway leaders Barcelona, who beat Levante 3-0 to stay nine points clear at the top of La Liga.
Real are unbeaten since February, winning 10 of their last 12 games. In contrast, Barcelona have won just two of their previous five in all competitions and were dumped out of Europe in midweek.
Bayern left fuming over Champions League 'robbery'.
Juventus rehire Allegri.
European champions Real Madrid turned on the party tricks as they sailed into the Club World Cup final by crushing Cruz Azul 4-0 in Marrakech.
Real Madrid defender Raphael Varane made up for the absence of Sergio Ramos by scoring one goal and making another to help his side to a hard-fought 3-0 win at Getafe. La Liga leaders Barcelona were held to a 2-2 draw at struggling Espanyol on Saturday as China striker Wu Lei came off the bench to grab a late equaliser in a pulsating city derby.
Memories and images of Johan Cruyff will provide an emotional backdrop to Saturday's Nou Camp 'Clasico' against Real Madrid when Barcelona pay tribute to the man who transformed the club from also-rans into one of the game's superpowers.
Former Manchester United manager Alex Ferguson once said he would not sell Real Madrid "a virus" let alone Cristiano Ronaldo but, as even he found out, when the Spanish giants come knocking they usually get what they want.
Ronaldo had failed to score in his last four league games for Real and his rotten run in front of goal looked set to continue when his spot-kick was turned away by visiting goalkeeper Roberto.
Jose Mourinho has committed himself to Premier League champions Chelsea until at least 2019 after signing a new four-year contract as manager, the west London club said on Friday.