According to widespread Spanish media reports, Netherlands coach and former Barca defender Ronald Koeman is set to be named as Setien's successor.
Barca play their final league La Liga game of the season at Alaves on Sunday before hosting Napoli on Aug. 8 in the second leg of their Champions League last-16 tie.
The defender later became the club's assistant coach before embarking on an eventful career as a head coach, managing Dutch sides Ajax Amsterdam, PSV Eindhoven and Feyenoord plus Premier League sides Southampton and Everton and La Liga's Valencia.
La Liga returned to action after a long hiatus and during Barcelona's first game after the resumption, Messi struck a brilliant goal, helping his side clinch a 4-0 win against Mallorca.
The 55-year-old Ernesto Valverde, who led Barcelona to successive La Liga titles in 2018 and 2019, came under fire this season for the team's dip in performance levels even though they top the league standings at the halfway point of the campaign.
Barcelona gave up more ground to Real Madrid in La Liga's title race on Tuesday after being held to a 2-2 draw at home to third-placed Atletico Madrid as a late penalty from Saul Niguez cancelled out Lionel Messi's 700th career goal. The draw meant the Catalans stayed second in the standings on 70 points and leaders Real Madrid, who have 71, will go four points clear at the top with five games left if they beat Getafe at home on Thursday.
Spanish media had reported that Xavi had been approached by Barca to replace Ernesto Valverde before Quique Setien was appointed in January.
La Liga champions Barcelona fell to their first defeat in three games under new coach Quique Setien as they were beaten 2-0 away at Valencia on Saturday. Barca are still top of the standings on 43 points after 21 games but second-placed Real Madrid, who are also on 43, can go three points clear at the summit if they beat Real Valladolid away from home on Sunday.
Setien was named Barcelona coach late on Monday, tasked with the job of restoring the club's iconic passing style, but the appointment represents a huge gamble for the Catalans given the 61-year-old's lack of success at the highest level.
Dutchman Ronald Koeman has signed a two-year-deal with Barcelona.
Messi's fitness was a major concern ahead of the resumption -- the talismanic forward was dealing with a quadriceps injury. But he has suffered no further setbacks since returning to training with the rest of the squad at the start of the week.
Barcelona said on Saturday they had named former midfielder and captain Xavi Hernandez as head coach on a contract until 2024, following the sacking of Ronald Koeman.
Setien's complaint piled yet more pressure on president Josep Maria Bartomeu less than an hour after a group seeking his removal announced they had gathered enough signatures to force a vote of no-confidence against him.
The Spanish media showed no mercy to Barcelona after their epic 8-2 defeat by Bayern Munich in the Champions League quarter-finals, calling for huge changes at the club after a night that will be difficult to erase from their memory.
The Barca coach said the squad is in a good place both mentally and physically and very motivated to take the field.
Having won eight of the past 12 league titles coming into this campaign, where has it gone so wrong for Barcelona?
Spain striker Iago Aspas dealt a fresh blow to Barcelona's La Liga title hopes by striking a late free kick to snatch a 2-2 draw at home to the Catalans on Saturday as Quique Setien's side twice threw away the lead in a thrilling match. The draw put Barca back on top of the table on 69 points after 32 games but Real Madrid, on 68, can go two points clear at the summit if they beat Espanyol away from home on Sunday.
Barcelona president Josep Maria Bartomeu's remarks come amid severe speculation around Messi's future at the club.
News of all that transpired on and off the football field.
La Liga has been on hold since March 10 although president Javier Tebas said last week that the league could start up again on either May 29, June 7 or June 28, adding that the games were likely to be held without spectators. But Barcelona coach Quique Setien does not think it is so simple.
With no fans allowed into venues and Real playing their home games at the 6,000-capacity Alfredo Di Stefano stadium while the Santiago Bernabeu is being refurbished, it will be a title race unlike any other.
Calling his side 'weak', 'inconsistent' and 'very easy to score against', Lionel Messi called for urgent changes
Barcelona beat third-placed Getafe 2-1 at home on Saturday to stay on the heels of La Liga title rivals Real Madrid but the champions were made to sweat for all three points by the impressive visitors. Antoine Griezmann sent the Catalans ahead in the 34th minute with a cool finish with the outside of his left foot after being played in by an outstanding pass from Lionel Messi, while Sergi Roberto doubled Barca's lead five minutes later.
Barca, chasing a third consecutive Spanish title, are on 76 points after 35 games while Real Madrid are top with 77 and can restore their four-point advantage when they host Alaves on Friday.
Real Betis right-back Emerson Aparecido's first year in La Liga went superbly well, but there is plenty to come from one of the league's most talented and determined rising stars.
News of all that's transpired on and off the football field.
Betis fans bow to 'extraordinary' Messi after sublime hat-trick Lionel Messi is used to receiving adulation at the Nou Camp but on Sunday he got a rapturous reception from rival supporters for a majestic hat-trick in Barcelona's 4-1 win at Real Betis. Messi opened the scoring with an unstoppable free kick then combined with devastating effect with Luis Suarez to carve Betis open and score a second goal right before halftime. The Argentine saved his best goal for last, completing a victory which took Barca 10 points clear at the top of La Liga with a spectacular first-timed chip from the edge of the area after playing a one-two with Ivan Rakitic. Beaten Betis goalkeeper Pau Lopez looked on in awe while the home supporters, renowned for devotion to their side, rose to their feet, bowed down to Messi and chanted his name. "Even though the opposition concedes goals to Messi they can still enjoy this unbelievable era which he has created, they enjoy it too and today they recognised that," said Barca coach Ernesto Valverde. "It's significant that they gave him this ovation, it's an acknowledgement. Our rivals' supporters have to suffer him but they also appreciate him, because of the player he is. "Leo's performance was extraordinary, he got three goals but he could have got four, that shows you how good he is." Betis coach Quique Setien commended his supporters for their treatment of Messi while saying he felt honoured to work in the same era as the Argentine. "I really like the fact that our supporters showed their appreciation for a great player, today he really made us suffer," Setien said. "It's only fair and it's right to recognise this, our fans behaved in an extraordinary way and I'm very proud of them. I've seen some magnificent players do great things but no-one can match the things Messi has done over the last 12 years. "It's a privilege to have been able to start this era with him and see him in action every weekend." The five-times world player of the year moved on to 39 goals in all competitions this season with two months still left in the campaign. It was Messi's 51st career hat-trick but he could not recall receiving such applause from a rival team's fans. "I cannot remember anything like this before and I'm very grateful for the fans' reaction," Messi said. "I'm very grateful to them and happy for the victory, which was very important."
Real Madrid suffered a shock 1-0 home defeat to Real Betis on Wednesday as an inspired performance from their former goalkeeper Antonio Adan and a stoppage-time winner from Antonio Sanabria stunned the Liga champions.
Real Madrid showed their character by beating Barcelona 2-0 in Sunday's top-of-the-table 'Clasico', leapfrogging their rivals at the La Liga summit after a week in which their pride had taken a beating at home and in Europe. Brazilian teenager Vinicius Jr scored the opener in the 71st minute with a strike that deflected off Gerard Pique, flummoxing goalkeeper Marc-Andre ter Stegen who had made some jaw-dropping saves, and substitute Mariano added the second in added time.
Barca won their fifth European Cup in 2015 and the signs of decline have been evident over the past five years since -- but no-one envisaged a fall as great as this.
Here is how some Barca and Bayern players reacted to the result.
Champions Barcelona lost 2-0 at Celta Vigo while Getafe earned an important 2-0 win over Girona in their bid to secure Champions League qualification.
IMAGES from the Champions League quarter-final played between Barcelona and Bayern Munich in Lisbon on Friday.
Messi's damning assessment of the team came home to roost when the season re-started after the coronavirus stoppage and Barca surrendered the league title to Real Madrid, prompting the captain to launch a new tirade against the team.
News of all that's transpired on and off the football field.
'I would never go to court against Barca because it is the club that I love, which gave me everything since I arrived. It is the club of my life, I have made my life here.'
La Liga leaders Barcelona moved 10 points clear with a 4-1 win at Real Betis on Sunday after second place Atletico Madrid slipped up at Athletic Bilbao on Saturday in a 2-0 defeat.
Zinedine Zidane has said his side are in a delicate situation as they prepare to host arch-rivals Barcelona in a La Liga title showdown on Sunday
The win increased Zinedine Zidane's side's advantage at the top of the standings to six points
It was Messi's 56th converted penalty in La Liga and saw him draw level with Hugo Sanchez as the league's second-top penalty taker, behind record holder Cristiano Ronaldo on 61.