Barcelona were held to a frustrating 0-0 draw at Olympique Lyonnais in their Champions League last-16 first leg on Tuesday as both sides remained unbeaten in this season's competition.
Liverpool manager Brendan Rodgers conceded his team has been hit by the departure of controversial-but-prolific striker Luis Suarez as they prepare to take on Champions League winners Real Madrid on Wednesday.
Barcelona forward Ousmane Dembele scored twice and produced a mesmerising display to fire his side to a 5-1 win over Villarreal on Wednesday which stretched the champions' unbeaten run this season to 36 games with two remaining.
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Jose Mourinho's first Premier League game as manager of Manchester United ended in a comfortable 3-1 victory away to Bournemouth on Sunday.
Manchester City maintained their perfect start to the season with a 2-0 victory over promoted Watford as champions Chelsea suffered a shock 2-1 home defeat by Crystal Palace on Saturday.
Philippe Coutinho inspired Liverpool to a comfortable 3-1 home win over Everton in the 228th Merseyside derby on Saturday to move provisionally up to third in the Premier League.
West Ham United capitalised on two mistakes from Arsenal's new goalkeeper Petr Cech to claim a surprise 2-0 victory at the Emirates and bring the Gunners' early Premier League optimism down to earth with a bump on Sunday.
Cristiano Ronaldo scored the 750th goal of his remarkable career in a 3-0 win over Dynamo Kyiv on Wednesday
Liverpool's hopes of winning their first title in 24 years suffered a huge setback when they lost 2-0 at home to Chelsea and Manchester City took advantage with a 2-0 victory at Crystal Palace.
Portugal captain Cristiano Ronaldo struck his fifth international hat-trick, including a spectacular volleyed opener, to lead the European champions to a 5-1 win over the Faroe Islands in their World Cup qualifier on Thursday.
Lionel Messi came off the bench to inspire Barcelona to a 3-1 win over a dogged Leganes side on Sunday, creating one goal and scoring another to keep the Catalans five points clear at the top of La Liga.
Manchester United teenager Marcus Rashford wrote another chapter in his fairytale introduction to top-flight football, scoring a brilliant goal to secure a 1-0 win in his first derby match against Manchester City on Sunday.
Liverpool handed their fiercest rivals a painful lesson on Thursday with a dominant 2-0 win over Manchester United in the first leg of a Europa League last-16 clash.
Images from the English Premier League matches played on Saturday
After seven consecutive league defeats, and one point from the last 30 on offer, had plunged Villa into crisis and cost Tim Sherwood his job, the former European champions produced a gritty display to frustrate City.
Sergio Aguero scored a hat-trick as free-scoring Manchester City climbed to the top of the Premier League with an irresistible 6-0 victory against Watford on Saturday.
Defending champion Germany suffered a shocking defeat, while Brazil, Spain and Argentina -- the other pre-tournament favourites -- managed just draws in their opening round matches.
Liverpool's 1-0 defeat by Aston Villa on Saturday was more than an early season setback - it raised the question of whether they have the strength in depth to cope with the dual challenge ahead of them this term.
Real Madrid's stuttering season continued as they were reduced to 10 men and then slumped to an 11th La Liga defeat of the campaign by going down 3-1 at Real Sociedad.
Champions Barcelona reclaimed top spot in La Liga on Sunday by overcoming a dogged Villarreal side to win 2-0 at home with goals from stalwart defender Gerard Pique and youngster Carles Alena taking them above Sevilla.
Images from the UEFA Champions League quarter-final first leg matches played on Wednesday
An inspired Matteo Darmian scored his first goal for Manchester United and set up another as Louis van Gaal's side kept alive their hopes of a top-four finish with a 2-0 home win over Crystal Palace on Wednesday.
Jose Mourinho's wretched week ended on a high note as Manchester United's big guns Zlatan Ibrahimovic and Paul Pogba finally began firing, both finding the target in a 3-1 win at dismal Swansea City on Sunday. Mourinho watched from the stands at the Liberty Stadium following his touchline ban imposed by the Football Association on Wednesday and was buoyed to see Ibrahimovic score twice -- his first league goals in eight weeks -- and Pogba net a superb volley. United, vastly improved after their midweek Europa League defeat at Fenerbahce, went ahead with a 15th minute strike from Pogba worthy of his 89 million pounds price tag before Ibrahimovic ended his goal drought with a sharp first-half double in the space of 12 minutes.
An Eden Hazard hat-trick swept Chelsea back to the top of the Premier League on Saturday when they beat Newcastle United 3-0 at Stamford Bridge after previous leaders Arsenal were thrashed 5-1 at Liverpool.
Manchester City swept aside second-tier Cardiff City 2-0 with first-half goals from Kevin De Bruyne and Raheem Sterling on Sunday to reach the FA Cup fifth round in their quest to win an unprecedented four trophies this season.
Images from the football matches played across Europe on Sunday
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Valverde said he was concerned about the team's away form after they were comprehensively beaten 2-0 by promoted Granada
IMAGES from La Liga matches played on Sunday
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Injuries have blighted Liverpool's start but Adam Lallana is back in full training after damaging his thigh pre-season and is expected to feature while another injury concern, Sadio Mane, also trained on Wednesday after tweaking a hamstring on international duty with Senegal.
Tottenham Hotspur brutally exposed Liverpool's defensive frailties as Harry Kane plundered two more goals in his side's 4-1 romp at Wembley on Sunday.
Juve forward Cristiano Ronaldo had an unusually quiet game after scoring a hat-trick against Atletico in last year's competition, although he came within inches of grabbing a last-gasp winner when he sent a shot just past the far post.
Images from the English Premier League matches played on Saturday
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Infinite Analytics CEO Akash Bhatia and Lead Scientist Joseph Kibe reveal how AI reads Wikipedia index noise to pull out the winners.
Liverpool added another fairytale comeback to the history books as they fought back from 3-1 down against Borussia Dortmund to reach the Europa League semi-finals after Dejan Lovren's towering stoppage-time header secured a 4-3 win on Thursday.
Lionel Messi fittingly sealed Barcelona's 26th La Liga title on Saturday by coming off the bench to score the goal in a 1-0 win over Levante in front of a jubilant Nou Camp crowd, who celebrated a remarkable eighth league crown in 11 years.