The 33-year-old Swiss, ranked 261 in the world after two knee surgeries, served solidly throughout a one-sided contest on the slick centre court, easing past an opponent who struggled to cope with Wawrinka's power.
Two-time Grand Slam winner Victoria Azarenka crashed out of the French Open in the first round losing 5-7, 5-7 to Katerina Siniakova on Monday, playing only her fifth tournament of the year after a legal battle over the custody of her son.
Defending champion Djokovic fired his 15th ace on match point to defeat Querrey but his serve had been an issue earlier in their second-round encounter.
For all their success together, the red dirt isn't Sania Mirza and Martina Hingis' most favourite surface.
Images from Day 2 of the 2022 Australian Open in Melbourne on Tuesday.
Summary of sports events and persons who made news on Thursday
Big-serving Isner reaches Montreal second round
Images from Day 6 of Wimbledon at the All England Lawn Tennis and Croquet Club in London, on Saturday.
The Frenchman, seeded five, had no answer to left-hander Muller's swinging serve as he bowed out 6-4, 6-4.
Images from Day 7 of the 2021 French Open at Roland Garros in Paris on Saturday.
A summary of sports events and persons who made news on Friday
Top seed Dominic Thiem was knocked out the Rio Open in the first round on Tuesday, going down 6-3, 6-3 to Laslo Djere.
A summary of Friday play at the French Open.
A summary of sports events and sports persons, who made news on Friday.
Czech defending champion Katerina Siniakova fended off Maria Sharapova in a fiercely contested match at the Shenzhen Open on Friday to set up a final with world number one Simona Halep.
Images from the Australian Open matches played at Melbourne Park on Wednesday.
Images from Day 9 at the French Open.
Summary of sports events and persons who made news on Wednesday
A day after celebrating his 36th birthday, Federer played the aggressive game that has propelled him to five titles, including two grand slams, this year, attacking the net and rocketing second serves.
The Danish World No 3 ended 2017 with the biggest title of her career in Singapore and returned a day after thrashing Madison Brengle in her season opener to hit 21 winners against eight unforced errors in the 53-minute win over Martic.
IMAGES from Day 3 of the US Open in New York on Wednesday.