The injury will also rule him out of the reigning European champions' two Champions League quarter-final legs against last year's runners-up Paris St Germain, scheduled for April 7 and April 13.
Seydou Keita cancelled out a superb Carlos Tevez free kick as second-placed AS Roma fought back with 10 men for a fiery 1-1 draw at home to leaders Juventus who stayed on course for a fourth successive Serie A title on Monday.
Zlatan Ibrahimovic curled home a stunning freekick and then turned provider as AC Milan moved to within one point of Juventus at the top of Serie A with a 3-0 home win over Cagliari on Sunday.
Juventus continued their charge towards a fourth successive Serie A title as they predictably swept aside AC Milan 3-1 on Saturday to complete a league double over their old rivals.
Ibrahimovic and Lukaku, who played together at Manchester United, exchanged words at the end of the first half before the pair had to be restrained as the players left the pitch for the interval.
Juventus joined AC Milan at the top of Serie A but failed to get the win they needed to end the year clear in Serie A after a disappointing 0-0 draw at title rivals Udinese on Wednesday as Napoli hit six against Genoa.
Buoyant AC Milan moved clear in second spot in Serie A with a 3-0 home win over 10-man Palermo on Sunday, putting a modicum of pressure on leaders Inter Milan.
Edin Dzeko scored twice to set up a 3-1 win for AS Roma away to Napoli in the battle for second place in Serie A on Saturday and Paulo Dybala also notched up a brace for leaders Juventus in their 2-1 win over Udinese.
A summary of Wednesday night's action in the UEFA Champions League.
Lazio came from behind to beat Juventus 2-1 at home in the first leg of their Italian Cup semi-final on Tuesday thanks to second-half goals by Goran Pandev and Tommaso Rocchi.
Argentine Dybala has scored seven goals in four games for Juventus this season, including a hat-trick against Genoa in Serie A on August 26.
Real Madrid failed in their attempt to sign France striker Kylian Mbappe from Paris Saint Germain on the final day of the transfer window as Cristiano Ronaldo completed his move from Juventus to Manchester United.
Images from football matches played in Europe on Sunday.
Genoa handed Serie A leaders and titleholders Juventus a dramatic first league defeat of the season when Luca Antonini scored in the fourth minute of stoppage time to give them a 1-0 win on Wednesday.
The Champions League will resume in August after being halted in March due to the COVID-19 pandemic with a 'Final Eight' tournament being held in Lisbon after the remaining second-leg games from the last 16 ties are decided.
Antonio Conte made an uncharacteristic hash of his team selection against Bayern Munich last week and the Juventus coach cannot afford to get it wrong again as his side chase a two-goal deficit on Wednesday.
Lionel Messi scored a penalty for the third Champions League game in a row with the Spaniards maintaining their winning start to the group stage.
Juventus defender Dani Alves produced an inspired display capped by a stunning volleyed goal in a 2-1 win over AS Monaco on Tuesday that took the Italians into their second Champions League final in three years.
Cristiano Ronaldo's Champions League debut for Juventus lasted only 29 minutes as he was red-carded but the Italians began their Group H campaign impressively with a 2-0 victory at Valencia on Wednesday. Penalties either side of halftime by Miralem Pjanic sealed the points for the visitors as Valencia's return to European competition after a two-year absence fell flat.
Manchester City's volatile striker Mario Balotelli could soon be on his way back to his native Italy with sources familiar with the talks saying AC Milan and Juventus are interested in a deal.
Argentina forward Carlos Tevez is to leave Juventus after two seasons in which he has revived his career and will rejoin Boca Juniors, the club where he started out and remains a cult figure.
AS Roma stalwart Francesco Totti came off the bench with four minutes left and scored twice to give his Champions League-chasing side a dramatic 3-2 win over Torino in Serie A on Wednesday.
Lazio goalkeeper Fernando Muslera watched in horror as Marco Borriello's weak penalty crept under his body and dribbled into the net to help city rivals AS Roma to a 2-0 win over the Serie A leaders on Sunday.
Manchester United moved to the top of the Premier League with a comfortable 2-1 win over Arsenal, a match that saw striker Robin van Persie face his old side for the first time.
Manchester United moved to the top of the Premier League with a comfortable 2-1 win over Arsenal, a match that saw striker Robin van Persie face his old side for the first time.
Mario Gomez dusted off his shooting boots to put Fiorentina in the driving seat with a 1-1 Europa League draw at Juventus while Benfica were too good for Tottenham Hotspur, winning their last-16 first leg 3-1 away on Thursday.
They say never go back, but United fans had been longing for Ronaldo to rejoin their side for many years, more in forlorn hope than anything else.
Leaders Juventus stayed three points clear in Serie A on Sunday after they thumped lowly Novara 4-0 and second-placed AC Milan won 4-1 at Siena with Antonio Cassano scoring for the first time since heart surgery in October.
AC Milan took their time but eventually eased past bottom side Novara 3-0 to stay on the tail of Serie A leaders Juventus on Sunday as Udinese and Inter Milan also won.
News of all that's transpired on and off the football field
Barcelona crashed out of the Champions League following a 3-0 defeat at Bayern Munich on Wednesday, failing to make it past the group stage of the competition for the first time since the 2000-01 season.
Juventus striker Zlatan Ibrahimovic will miss his club's title showdown with AC Milan next month.
Barcelona must wait a bit longer before they can claim their La Liga crown after drawing 2-2 with Athletic Bilbao, while Paris St Germain and Juventus continued to close in on the French and Italian titles.
Juventus's hopes of reaching the Champions League last eight suffered a blow when the two-times European Cup winners slumped to a 1-0 defeat in their last-16 first leg at Olympique Lyonnais on Wednesday. Manchester City finally produced a Champions League performance worthy of their status as one of European football's elite clubs by beating Real Madrid 2-1 away in Wednesday's last-16 first leg after pulling off a stunning late fightback.
This weekend's FA Cup final is expected to have 21,000 fans present.
Cristiano Ronaldo scored two goals as Real Madrid thrashed Juventus 4-1 in the final to win the UEFA Champions title, in Cardiff, on Saturday.
The five-time Ballon d'Or winner returned to his homeland prior to the COVID-19 pandemic shutting down football around the world.
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