With the Catalans shorn of three of their top forwards, all eyes will be on Griezmann in his first appearance at the Camp Nou since his 120-million-euro ($133 million) move from Atletico Madrid, and not least because Barca need a win to kickstart their season.
'He's an exceptional talent, him and Cristiano have been the best players in the world the last decade and he showed why we think that and why this team have won the Champions League so many times'
Barcelona fell to a first home defeat in any competition for more than two years
Barcelona opened up a four-point gap at the top of La Liga, maintaining their 100 percent start as they cruised to a 3-0 victory at Catalan rivals Girona on Saturday.
Lionel Messi said his side were superior to every team in the league after he scored a hat-trick in Sunday's 4-2 win at Deportivo which clinched the club's 25th Spanish title with four games left in the season.
Real will ease the pain by retaining their Champions League title, their only hope of salvaging a disappointing season.
Spanish media paid tribute to Barcelona captain Andres Iniesta after he starred in his side's 5-0 thrashing of Sevilla in the King's Cup final on Saturday.
Coutinho, who arrived from Liverpool for a club record 165 million euros ($185.18 million) in January 2018, has so far shown little to suggest he will be able to compensate for Frenchman Ousmane Dembele's absence against Lyon in the UEFA Champions League tie.
Real play Athletic Bilbao while Barcelona visit Real Sociedad in fixtures that have often proved to be among their hardest away trips over the last decade.
'They were better than us for some spells and we know what awaits us over there' Valverde pointed to his team's sensational exit from last year's competition to AS Roma after a 4-1 cushion from the first leg and said they would be taking nothing for granted in Tuesday's return game at Anfield.
Barcelona have one hand firmly on the La Liga title after winning 2-0 at Alaves on Tuesday, leaving them 12 points clear at the top of the table with four games to play.
The Catalans will not just be looking to extend their domestic hegemony, though, as they have spent a combined 250 million euros ($280 million) on a renewed bid to win the Champions League.
Unzue is one of the two leading candidates to succeed Luis Enrique, who announced this month he will leave at the end of this season, along with Athletic Bilbao coach Ernesto Valverde.
'I arrived at Manchester United a boy, and I left a man'
De Jong is proud to join the likes of compatriots Ronald Koeman, Frank de Boer and Patrick Kluivert in heading to the Nou Camp, having dreamed of wearing Barca colours.
'It has been good on pitch and off pitch,' Lampard said.
Real coach Julen Lopetegui has come in for fierce criticism this season, having presided over a run of five games without a win -- the team going eight hours and one minute without scoring -- before Tuesday's unconvincing 2-1 triumph over Viktoria Plzen that saw the team whistled off the pitch by their own fans.
Lionel Messi scored one penalty and missed another as Barcelona beat Real Valladolid 1-0 on Saturday to open up a seven-point lead at the top of La Liga.
Frenchman Lenglet's first league start since his 36 million-euro move from Sevilla turned sour when he was shown a straight red card in the 35th minute at the Nou Camp following a coming together with Pons, after referee Jesus Gil Manzano consulted the video assistant referee (VAR).
Catalans will have to cope without their inspirational captain Andres Iniesta, the man who has pedigree when it comes to beating the Blues.
After an even first 45 minutes, strikes from Pablo Sarabia and Wissam Ben Yedder stunned the Catalans and left them needing a second-leg comeback at the Nou Camp for the second consecutive round in the competition.
Barcelona were held to a 1-1 draw at relegation-fighting Las Palmas on Thursday in an unexpected setback that left them with a five-point lead in La Liga ahead of their top-of-the-table showdown with Atletico Madrid this weekend.
Setien's complaint piled yet more pressure on president Josep Maria Bartomeu less than an hour after a group seeking his removal announced they had gathered enough signatures to force a vote of no-confidence against him.
Barcelona lifted the Spanish Super Cup for a record extending 13th time by coming from behind to beat Sevilla 2-1 on Sunday thanks to a stunning strike from France winger Ousmane Dembele and a penalty save in stoppage time from Marc-Andre ter Stegen.
It was Messi's 30th goal in 39 competitive games against Atletico
Here are five talking points from the weekend's La Liga action:
Images from the La Liga match played between FC Barcelona and Sevilla on at Camp Nou on Sunday
La Liga leaders Barcelona beat Real Madrid 1-0 to all but knock their rivals out of the title race on Saturday, while second-placed Atletico Madrid stayed seven points behind the Catalans with a 2-0 win at Real Sociedad on Sunday.
The victory takes Barcelona up to fourth with 10 points after six games, one point behind surprise leaders Granada, Athletic Bilbao, who visit Leganes on Wednesday, and Real Madrid ahead of their game at home to Osasuna the same night.
'I've been here 20 years and many times had the opportunity to leave. I don't have to convince you my preference has always been Arsenal'
Manchester City have never gone past the semi-final stage of Europe's premier club competition.
Barcelona rubber-stamped a decade of domestic dominance by clinching the La Liga title on Sunday
Lionel Messi scored a record eighth Champions League hat-trick as Barcelona kick-started their campaign with a 4-0 home win over PSV Eindhoven, although they had defender Samuel Umtiti sent off late in the second half on Tuesday.
Levante claim that Barcelona's teenage defender Chumi Brandariz, who played in the first leg, was ineligible to take part in the match because he was suspended.
News of all that's transpired on and off the football field
Barca's second-half stamina key to their massive lead in the standings this season
Messi's damning assessment of the team came home to roost when the season re-started after the coronavirus stoppage and Barca surrendered the league title to Real Madrid, prompting the captain to launch a new tirade against the team.
Lionel Messi lifted Barcelona out of their recent slump with two goals in a vintage display as his side survived a tenacious Tottenham Hotspur fightback to claim a 4-2 victory in Champions League Group B on Wednesday.
Barcelona have been frighteningly good at home this season, scoring 15 goals in three games at the Nou Camp.
Unstoppable duo Andres Iniesta and Lionel Messi helped Barcelona thrash Sevilla 5-0 to win the King's Cup final for the fourth consecutive season on Saturday as they close in on a likely domestic double.
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