Federer and Nadal had both opted out of this year's tournament, while Djokovic exited in the fourth round after an infamous swat of his racket sent a tennis ball into a line judge's neck.
Stefanos Tsitsipas confirmed his meteoric rise into the highest echelon of men's tennis by battling back to beat Austrian Dominic Thiem 6-7(6) 6-2 7-6(4) in a compelling title duel at the ATP Finals on Sunday.
Factbox on Rafael Nadal, who beat Dominic Thiem 6-4, 6-3, 6-2 to win his 11th French Open title on Sunday:
World number five Dominic Thiem heads into Friday's Australian Open semi-final against Alexander Zverev knowing he will have to put their friendship aside to continue his charge towards a maiden Grand Slam title.
'I am not too disappointed. I feel like he had to come up with the goods, and it did feel like to some extent it was on my racquet, I just came up against somebody who was, on the day, a bit better when it really mattered'
Former world number one Rafa Nadal wasted a match point as he slipped to a surprise semi-final loss to Austrian Dominic Thiem on his beloved clay at the Argentina Open on Saturday.
Wimbledon debutant Eubanks ends Tsitsipas's challenge in fourth round.
Victoria Azarenka, 31, won a bronze medal for Belarus in singles and a gold in mixed doubles at the 2012 Summer Games in London. Angelique Kerber, 33, won the silver in singles for Germany at the 2016 Olympics in Rio de Janeiro.
Djokovic said he was '50-50' about competing at the Tokyo Olympics
The opening match in the Pete Sampras Group produced a feast of stylish backhands from both players but it was Dimitrov, the first Bulgarian to qualify for the tournament in its 48-year-old history, who overcome some late jitters to prevail.
Dominic Thiem will watch a treasured home movie of his recent win over Novak Djokovic at the season-ending ATP Tour Finals as he seeks inspiration to take down the defending champion Serb in the Australian Open decider.
Second seed Novak Djokovic outclassed Roger Federer in straight sets to enter the final of Australian Open in Melbourne on Thursday. Seven-time champion Djokovic started off slowly before he took complete control to register an emphatic 7-6, 6-4, 6-3 victory in the first semi-final.
Gaston keeps French flag flying at Roland Garros.
Thousands of mask-free spectators flocked into the stadium
The German picked up two ATP titles in Cologne and also made the final of the ATP Masters 1000 event in Paris in an encouraging close to the season.
The Serb, who turned 30 last month, will drop outside the top two for the first time since march 2011 on Monday -- quite a contrast to a year ago when his domination of men's tennis was complete after winning the French Open for the first time.
But for the first time, that golden trio will be having an anxious glance over their shoulders. The past week in London has revealed a new fearlessness in the generation of 20 somethings expected to fill the void when they call it a day.
Thiem, who also played in the charity event but did not contract the virus, told Austrian media that Kyrgios had "made a lot of mistakes" and should not criticise others.
World number one Rafael Nadal has been drawn alongside defending champion Alexander Zverev, Association of Tennis Professionals (ATP) reported.
'During the grass court season, I unfortunately experienced a setback with my knee, and have accepted that I must withdraw from the Tokyo Olympic Games.'
Djokovic will be nowhere near the centre court after losing his bid to overturn a second visa cancellation.
The major milestones in Djokovic's career
Nadal enters his title defence after a stellar season on his favourite surface.
The world number one overcame a sluggish start to defeat Argentine Diego Schwartzman 7-5, 6-3 for a record 36th ATP Masters crown.
Halep said she would not recover from a calf injury in time, Wawrinka underwent foot surgery that would rule him out of the Games
Medvedev became only the fourth player in ATP history to beat the world's top three at the same tournament.
Djokovic saved a fifth match point but Thiem finally got the job done when he forced his opponent to float a defensive forehand over the baseline.
IMAGES from the French Open semi-finals played at Roland Garros on Friday
Not that cash will be the motivator for world number one Novak Djokovic, Rafa Nadal, Dominic Thiem, Tsitsipas, Daniil Medvedev, Alexander Zverev and debutants Andrey Rublev and Diego Schwartzman when the tournament's 50th edition starts on Sunday.
Dominic Thiem hailed Rafael Nadal's 'awesome' 11th French Open title after suffering a straight-sets defeat by the king of clay in the final at Roland Garros on Sunday.
Factbox on Rafael Nadal, who beat Dominic Thiem to win his 12th French Open title:
Deposed World No 1 Novak Djokovic suffered an early scare against Austrian debutant Dominic Thiem at the ATP World Tour Finals before launching his bid for a fifth successive title with a 6-7(10), 6-0, 6-2 victory.
Rafael Nadal is the oldest title winner in the history of the clay-court tournament.
Factbox on Rafael Nadal's French Open final wins
Alexander Zverev snatched the Laver Cup for Team Europe as he beat Canada's Milos Raonic in the final rubber of a thrilling three days of action in Geneva's Palexpo Arena on Sunday.
Earlier in the day, Croatia's Borna Coric said he has tested positive for coronavirus. He became the second player to test positive for COVID-19 after Bulgaria's Grigor Dimitrov.
In the video, which runs over nine minutes and was posted on Ines Ibbou's Instagram page, the world number 620 starts with "Dear Dominic" and goes on to talk about the difficulties she has had to endure and the sacrifices she needed to make in her career.
Dominic Thiem and Stefanos Tsitsipas won their respective singles matches before Roger Federer and Alexander Zverev teamed up in the doubles to beat Jack Sock and Denis Shapovalov
Three-time US Open champion Djokovic, who comes into the tournament having won his fifth Wimbledon title, is followed in the seedings by 2017 winner Rafael Nadal.