Barcelona's bid for a fifth La Liga title in six years suffered a surprise setback when the champions crashed to a 1-0 defeat at lowly Real Valladolid on Saturday.
The win took Barca to the top of the standings on 68 points although Real Madrid, on 65, will reclaim their lead due to their superior head-to-head record if they beat Real Mallorca at home on Wednesday.
Ten-man Premier League leaders Leicester City lost at title-chasing Arsenal, while La Liga pacesetters Barcelona crushed Celta Vigo and Juventus took over from Napoli at the top of Serie A by edging their rivals.
Following public comments from La Liga chief Javier Tebas, who said it was "not ideal" for the second El Clasico meeting between Real and Barca last season to be played with the latter having already won the league title, the two sides will face off earlier this campaign.
Leaders Real Madrid pulled three points clear of second-placed Celta Vigo when they held off the valiant 10-man Galicians to secure a nervy 3-1 victory in Saturday's top-of-the-table clash in La Liga.
Barcelona followed up Saturday's win over Real Madrid with another victory when Alexis Sanchez set the champions on their way to a 3-0 success at Celta Vigo on Tuesday that put them four points clear at the top of La Liga.
Here are five talking points from the weekend's action:
La Liga leaders Barcelona hit two goals in the final three minutes to earn a 3-2 win at Rayo Vallecano
Real Madrid did not specify if he would be out of action for any length of time
Barcelona drew 1-1 at Valencia after Real Madrid lost 1-0 away to Alaves, allowing Sevilla to go top of La Liga with a 2-1 home win over Celta Vigo on Sunday. Here are five talking points from the weekend's La Liga action.
La Liga leaders Barcelona were held to a 2-2 home draw by Celta Vigo on Saturday as their former assistant coach Juan Carlos Unzue dented the title hopes of the Catalans, who dropped points for the second game in a row for the first time this campaign.
Barcelona travel to newly-promoted Osasuna without their first choice front line.
Manchester United should be "embarrassed" at trailing Premier League leaders Chelsea by 19 points and Jose Mourinho's first year in charge will not be considered a success even if they win the Europa League, former skipper Roy Keane said.
Lionel Messi netted his first hat-trick in 10 months as Barcelona swept aside struggling Granada 4-0 to climb above Atletico Madrid to the top of La Liga on Saturday.
Barcelona beat third-placed Getafe 2-1 at home on Saturday to stay on the heels of La Liga title rivals Real Madrid but the champions were made to sweat for all three points by the impressive visitors. Antoine Griezmann sent the Catalans ahead in the 34th minute with a cool finish with the outside of his left foot after being played in by an outstanding pass from Lionel Messi, while Sergi Roberto doubled Barca's lead five minutes later.
Portugal international Goncalo Guedes fired Valencia into the lead in the 35th minute with a thumping shot from inside the area which was too powerful for Madrid goalkeeper Keylor Navas.
Real Betis right-back Emerson Aparecido's first year in La Liga went superbly well, but there is plenty to come from one of the league's most talented and determined rising stars.
Cristiano Ronaldo celebrated his recent Ballon d'Or award by scoring twice for the first time in a La Liga game this season as champions Real Madrid swept to a stunning 5-0 win over Sevilla on Saturday to go five points behind leaders Barcelona.
Real Madrid's Karim Benzema produced an audacious back-heeled assist for Casemiro to score as they beat Espanyol 1-0 away on Sunday to capitalise on Barcelona's slip-up a day earlier and move two points clear at the top of La Liga. Brazilian midfielder Casemiro slid to the ground to guide the ball home on the stroke of halftime after being played in by a stroke of genius from Benzema, who dragged the ball through the legs of his marker Bernardo Espinosa to find his team mate.
Jaume Costa atoned for giving away a first-half penalty when his strike five minutes from time rescued Villarreal a 1-1 draw against Eibar that put them fourth in La Liga on Sunday.
Holders Barcelona produced a second-half blitz to come from behind and beat Athletic Bilbao 3-1 to book a place in the King's Cup semi-finals after Atletico Madrid crashed out in a shock 3-2 defeat by Celta Vigo.
Premier League-based trio Diego Costa, Juan Mata and Santi Cazorla were among a high-profile list of absentees when Spain coach Vicente Del Bosque named his provisional 25-man squad for Euro 2016 on Tuesday. Costa injured his hamstring against Liverpool in Chelsea's penultimate game of the season. Atletico Madrid striker Fernando Torres was also absent from the squad despite his improved form towards the end of the season, as were Arsenal midfielder Cazorla and Valencia forward Paco Alcacer, Spain's top scorer in their qualifying campaign.
Real Madrid have exonerated Argentina winger Angel Di Maria over an incident in Monday's La Liga game at home to Celta Vigo when he was caught on camera grabbing his crotch while being substituted.
Lionel Messi scored yet another hat-trick and surpassed 400club goals as Barcelona came from behind to win the Catalan derby 5-1 against Espanyol.
The old format was skewed in favour of the bigger clubs, who could rest players for a first leg and swallow defeat before calling on their stars to turn the tie around in the return game.
Villarreal went top with a 1-0 win over Atletico Madrid on Saturday after a toothless Real Madrid were held 0-0 at home to 10-man Malaga and Lionel Messi suffered a serious injury as Barcelona beat Las Palmas 2-1.
News of all that's transpired on and off the football field.
Barcelona gave up more ground to Real Madrid in La Liga's title race on Tuesday after being held to a 2-2 draw at home to third-placed Atletico Madrid as a late penalty from Saul Niguez cancelled out Lionel Messi's 700th career goal. The draw meant the Catalans stayed second in the standings on 70 points and leaders Real Madrid, who have 71, will go four points clear at the top with five games left if they beat Getafe at home on Thursday.
Atletico Madrid fell to their heaviest league defeat of the season
Arsenal right back Hector Bellerin will be in Spain's Euro 2016 squad, the country's football federation said on Tuesday. The 21-year-old Bellerin and the other 18 players named to face South Korea in a friendly in Wals-Siezenheim, Austria on Wednesday, have been guaranteed spots in the European Championship squad. Bellerin was included after Real Madrid right back Dani Carvajal sustained a leg muscle injury in Saturday's Champions League final victory over Atletico Madrid. The Real Madrid and Atletico players in the squad will be named later on Tuesday when Spain coach Vicente del Bosque announces his final list.
Jose Mourinho admitted that Sunday's 2-0 defeat to Arsenal means it will now be "impossible" for Manchester United to finish in the top four.
Moffi penalty gives Lorient 1-0 win over Monaco.
Morata, who had scored his first goal for the club in last week's 2-0 win over Villarreal, rose to head home from close range on the half-hour mark following a corner which had been flicked on by Atleti captain Diego Godin.
Cristiano Ronaldo netted a first-half penalty as injury-depleted Real Madrid recovered from their derby defeat by Atletico Madrid at the weekend with a 3-1 win at Levante on Wednesday.
Valencia climbed above Atletico Madrid and Sevilla into third in La Liga when Alvaro Negredo came off the bench to score a late winner in a 3-2 home victory over his former club Almeria on Saturday.
"According to the report issued from the city hall in Vigo, they consider that the Balaidos stadium is not safe for spectators or for players to attend the game on Sunday," said a statement from La Liga.
A summary of Saturday's action in LaLiga, Ligue 1 and the Bundesliga.
Images from La Liga and German Cup matches played on the weekend.
Lionel Messi is back in the Argentina squad for next month's World Cup qualifiers against Brazil and Colombia after missing the last three due to injury in which his team have dropped seven points. Messi was named on Friday in coach Edgardo Bauza's 26-man squad and will captain Argentina away to arch-rivals Brazil in Belo Horizonte on Nov. 10 and at home against Colombia in San Juan five days later. Argentina have slipped down the South American group standings to fifth after a shock 1-0 home defeat by Paraguay and 2-2 draws with Peru and Venezuela, all without Messi.
Striker Aduriz opened the scoring in the sixth minute at the San Mames with a trademark header before midfielder Garcia, who joined from Atletico Madrid last month, nodded in a second in the 24th minute.
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