LaLiga club Barcelona will face Turkish side Galatasaray in the last 16 of the Europa League, while six-times champions Sevilla will play English Premier League club West Ham United after the draw took place on Friday.
Barcelona, who hammered Napoli in the knockout stage playoffs, will face a struggling Galatasaray team who are 13th in the Turkish top-flight.
West Ham have a tough task at hand against Sevilla, who are second in LaLiga and famously dubbed the Europa League specialists.
West Ham manager David Moyes previously worked in the Spanish top division, managing Real Sociedad in 2014-15.
In the other fixtures, Scottish champions Rangers, who stunned Borussia Dortmund in the last round, will face Red Star Belgrade while Braga are up against AS Monaco.
Portuguese club Porto will face French side Olympique Lyonnais, Atalanta will take on Bayer Leverkusen and Real Betis will face Eintracht Frankfurt.
RB Leipzig will face Russian side Spartak Moscow, who will play their home tie at a neutral venue, according to a decision made by European soccer governing body UEFA earlier on Friday.
The first legs of the last-16 ties will be played on March 10 and the second legs on March 17.
Porto and Betis will play their first legs at home on March 9 to avoid a clash with Braga and Sevilla, respectively.
Full draw:
Rangers v Red Star Belgrade
Braga v AS Monaco
Porto v Olympique Lyonnais
Atalanta v Bayer Leverkusen
Sevilla v West Ham United
Barcelona v Galatasaray
RB Leipzig v Spartak Moscow
Real Betis v Eintracht Frankfurt
