After a flawless first set from Mertens the tide turned in Andreescu's direction in the second when she fired a cross-court forehand winner to break the Belgian at love and take a 4-2 lead.
Rafael Nadal is generally a slow starter but should not have any problem getting past his first-round opponent, Germany's Yannick Hanfmann.
Roger Federer rallied from a set down to beat Moldovan surprise package Radu Albot 4-6, 7-5, 6-3 in a stuttering start to the 20-times Grand Slam champion's Miami Open campaign on Saturday.
Summary of sports events and persons who made news on Monday
The elbow injury sidelined him for six months after he was forced to retire at the quarter-finals of Wimbledon last year. He underwent a surgery for the same in February.
Suspected food poisoning forced Nick Kyrgios to pull out of his much anticipated quarter-finals showdown with Roger Federer at the BNP Paribas Open in Indian Wells.
Serena Williams was unseeded at the French Open last month due to an extended absence for the birth of her first child but she is not likely to face the same problem at the US Open.
Naomi Osaka is also the first woman to win a second Slam immediately after her first since Jennifer Capriati in 2001 but her meteoric rise has been followed by a distinct dip ahead of Roland Garros.
'You can't be frustrated all the time because the neighbour has a bigger house than you, or a bigger TV or better garden. That's not the way that I see the life, you know'
Roger Ferdrer came up with a solid all-round display to beat world No 1 Rafael Nadal 6-4, 6-3 in the final and win the Shanghai Masters on Sunday.
The selection committee has picked World No. 246 Prajnesh as Yuki's replacement as he is the next best singles ranked player.
Indian qualifier Prajnesh Gunneswaran achieved the biggest win of his career when he stunningly knocked out World No 18 Nikoloz Basilashvili at the Indian Wells ATP Masters event, continuing his dream run.
Big-serving Milos Raonic fought back from a set down to upset Rafa Nadal 4-6, 7-6(10), 7-5 in a pulsating quarter-final at the BNP Paribas Open on Friday.
Factbox on Romanian Simona Halep, who beat Sloane Stephens 3-6, 6-4, 6-1 to win the French Open title on Saturday:
World number one Novak Djokovic's French Open preparations were dealt with a blow as he suffered a 6-3, 4-6, 6-2 defeat by Russian Daniil Medvedev in the Monte Carlo Masters quarter-finals on Friday.
The 20-time Grand Slam champion decided to opt out of the event in order to attend an award ceremony in Monte Carlo.
Ukrainian second seed Elina Svitolina ended Naomi Osaka's remarkable recent run with a 6-4, 6-2 triumph over the Indian Wells champion in the second round of the Miami Open on Friday.
World number one Novak Djokovic on Wednesday dismissed any suggestion of friction with Roger Federer and Rafa Nadal as tennis politics spilled over to the Miami Open.
Indian tennis star Leander Paes feels blessed to have such a long career, having won 18 Grand Slam doubles titles and accumulated close to 1000 racquets.
The Tokyo 2020 Olympics torch lighting ceremony in ancient Olympia will be the first in more 35 years to be held without spectators after organisers introduced tighter measures to protect against the coronavirus. Here is a list of international sports events hit by the coronavirus outbreak.
A summary of sports events and persons who made news on Friday
World No 1 Novak Djokovic added to the sexism row, saying male tennis players should earn more money than their female counterparts as more people watch their matches.
The world No 1 is certainly buoyed by the prospect of emulating his achievement of holding all four majors but knows that nothing less than perfection will be required.
American teenager Amanda Anisimova, fresh off an impressive run at Indian Wells, beat China's Wang Qiang 6-3, 1-6, 6-2 at the Miami Open on Tuesday to set up a second round clash with Spanish third seed Garbine Muguruza.
A six-time champion at Flushing Meadows, Williams was once money in the bank when it came to the US Open
World No 4 Del Potro is still sidelined with a right knee injury sustained in Shanghai last month.
Bianca Andreescu, 19, the first Canadian to win a major in the professional era, prevented Serena Williams from equalling Margaret Court's record of 24 Grand Slam singles titles.
The 23-times Grand Slam champion looked a completely different player from the person who smashed her way into the semi-finals of the doubles with Caroline Wozniacki on Wednesday but managed to do just enough to beat the 86th-ranked McHale.
The first meeting between Nick Kyrgios and Stefanos Tsitsipas lived up to the hype on Saturday as the Australian saved a match point in a wildly entertaining 6-4, 3-6, 7-6(7) win to reach the Citi Open final.
In the ATP doubles, Leander Paes slid to 25, a loss of four places.
Tournament officials said there was no heat rule in effect on Friday for the first time in three days, with cloud cover expected to bring cooler temperatures.
A look at the form and previous records of Latvia's Jelena Ostapenko and Romanian Simona Halep ahead of the French Open final on Saturday
Roger Federer is no longer chasing the top ranking and would rather be a contender at Grand Slams than battling Novak Djokovic and Rafa Nadal to be world number one, the Swiss tennis great said.
Serbia's Novak Djokovic, who beat Switzerland's Roger Federer to win his 16th Grand Slam title on Sunday:
Nick Kyrgios has hit back at Bernard Tomic after his compatriot accused him of feigning illness to skip Australia's Davis Cup match against the United States at the weekend.
Roger Federer survived a stern test from Spain's Roberto Bautista Agut to reach the Miami Open quarter-finals on Tuesday, while top-seeded Swiss compatriot Stanislas Wawrinka was eliminated on his birthday.
The 'Indian Wells - Miami' tournaments are often labelled as the fifth major and players take pride in achieving the double. Here's a list the other players who have achieved the double in the same year.
It was a triumphant return to the tour for Djokovic
But for the 23-year-old Bouchard, a former world number five who has slumped to 56th in the rankings, it was another blow after her first-round exit in Indian Wells.
Top seed Rafa Nadal overwhelmed Russia's Daniil Medvedev 6-3, 6-0 to win his fifth Rogers Cup on Sunday in Montreal -- the first time he has retained a title outside of clay.