Atletico Madrid's Brazilian striker Diego Costa scored twice as they came from behind to beat Levante 3-2 at home on Saturday to go three points clear at the top of La Liga.
Carlo Ancelotti has become Real Madrid president Florentino Perez's latest managerial victim, just 366 days after delivering the club their much-awaited La Decima, a 10th Champions League title.
Neymar scored the opener to continue his rich vein of form as 10-man Barcelona won a one-sided La Liga derby against Espanyol.
Ten-man Premier League leaders Leicester City lost at title-chasing Arsenal, while La Liga pacesetters Barcelona crushed Celta Vigo and Juventus took over from Napoli at the top of Serie A by edging their rivals.
Paris St Germain's Zlatan Ibrahimovic scored his first Ligue 1 goal this season before missing a penalty as they beat En Avant Guingamp 3-0 to extend their lead to four points on Tuesday.
News of all that's transpired on and off the football field
2017 is full of long weekends! You won't regret planning your next trip to these wonderful cities.
Lionel Messi marked his 300th La Liga appearance with a record-equalling hat-trick and an assist for Neymar as Barcelona stayed hard on the heels of leaders Real Madrid with a 5-0 romp at home to Levante on Sunday.
Real Madrid returned to winning ways after last weekend's drubbing at Atletico but failed to convince and were whistled by their own fans during a drab 2-0 victory at home to Deportivo La Coruna on Saturday.
News of all that's transpired on and off the football field
Real Madrid were the big winners in Spain as their success at Almeria was followed by a Barcelona draw and a surprise Atletico Madrid defeat.
News of all that's transpired on and off the football field
Football news from Ligue 1, Bundesliga and La liga.
A weekend of surprise results across Europe's big leagues saw Bayern Munich's unbeaten run come to an end, Napoli knocked off top spot in Serie A and Manchester City toppled in the Premier League where Leicester City are the new leaders.
Atletico Madrid got their La Liga campaign up and running in less than convincing fashion when Antoine Griezmann's deflected free kick secured an edgy 1-0 win at home to promoted Las Palmas on Saturday.
US Open champions Marin Cilic and Serena Williams kicked off their China Open campaigns with straight sets victories against battling underdogs on Monday, but Rafael Nadal suffered defeat in a rare doubles outing on his return from injury.