The Swiss great is looking to win a 102nd tour-level trophy and move closer to Jimmy Connors' record of 109.
Roger Federer rallied from a set down to beat Moldovan surprise package Radu Albot 4-6, 7-5, 6-3 in a stuttering start to the 20-times Grand Slam champion's Miami Open campaign on Saturday.
Images from Day 5 of the US Open in New York on Friday
IMAGES from Day 3 of the US Open in New York on Wednesday.
Eugenie Bouchard's mid-season nosedive continued on Tuesday as the Canadian was swept aside 6-3 6-4 by Croatian qualifier Donna Vekic despite having home advantage and the backing of an excited crowd in a first round clash at the Rogers Cup.
Milos Raonic overcame third seed Grigor Dimitrov 7-5, 3-6, 6-3 to reach the third round at the Madrid Open on Tuesday and set up an all-Canadian clash with teenager Denis Shapovalov.
Summary of sports events and persons who made news on Wednesday
Garbine Muguruza's preparations for next week's Australian Open were thrown into disarray when the world number three pulled out of the Sydney International with a thigh injury on Wednesday.
Sania, the country's finest woman doubles player, who began the year with the number one ranking, closed it at number 9.
IMAGES from matches played at the Miami Masters in Key Biscayne, Florida
Images from the matches played at the All England Lawn Tennis and Croquet Club, in Wimbledon, London, on Monday.
A day after celebrating his 36th birthday, Federer played the aggressive game that has propelled him to five titles, including two grand slams, this year, attacking the net and rocketing second serves.
Former world number one Andy Murray withdrew from the Brisbane International with a hip problem on Tuesday, further putting in doubt the Briton's prospects of being fit in time for the Australian Open later this month.