He is the 14th player in history and only the second Indian to reach the milestone.
The tributes have been pouring in - and as the cricket loving public assimilate the enormity of the loss, more will follow. Below, find a preliminary round up - and it begins with this eulogy from a long-time mate and one of Anil Kumble's closest friends.
India's chief coach Anil Kumble has made it amply clear that opener KL Rahul would be making a comeback into the playing XI against England in the second Test starting on Thursday.
In a historic day for the Indian cricket, former Test captain Anil Kumble was on Sunday elected as president of the Karnataka State Cricket Association and the group led by him won 23 out of the 24 posts that went to the polls in Bangalore on Sunday.
Reader Chhavi Raj sent us this picture from Hong Kong.
The path found by champions like GR Viswanath, Syed Kirmani, Brijesh Patel, EAS Prasanna and BS Chandrasekhar has only broadened over the years through which several ace cricketers walked through.
Test skipper Anil Kumble has come out strongly in defence of the starry Indian middle-order batsmen who came a cropper against the Sri Lankan spin duo of Ajantha Mendis and Muthiah Muralitharan in the recently concluded three-match series in the Emerald Isle which the visitors lost 2-1.
Ace leg-spinner Anil Kumble says the forthcoming three-Test series against Pakistan is going to be tough in spite of the absence of the visitors' former captain Inzamam-ul Haq, who recently retired from the game.
India's captain paid rich tributes to his teammates, saying every player contributed to the six-wicket victory in the first Test against Pakistan.
The ace spinner appeared in 118 Tests before making his captaincy debut. Steve Waugh led Australia for the first time after playing 111 Tests.
Kumble was seen bowling 'left-arm spin' on the nets, most likely to tackle the left-arm Australian spinner in the remaining Tests.
Kevin Pietersen played down the spat he and India spinner Anil Kumble had on the final day of the third Test at The Oval on Monday and suggested it was because the bowler was just intent on a victory.
Anil Kumble surpassed Glenn McGrath to become the world's third highest wicket-taker in Tests.
Graciously skirting the controversy surrounding the snub Ravi Shastri received during his job interview, the newly-appointed Indian coach Anil Kumble on Wednesday said it's the players who are the most significant part of the system and no one else.
The India captain said his five-wicket haul on the opening day of the first Test against Australia is the best of his career.
Rohit Sharma and Rahul Dravid have enough options to choose from with selectors adding three players to the squad -- Sarfaraz Khan, Sourabh Kumar and Washington Sundar.
Kumble, who notched up the win against Pakistan in his maiden assignment as captain, said the strength of the side is their batting line-up but they also have bowlers who can take 20 wickets.
Lying in the Intensive Care Unit (ICU) of a Chennai hospital, Chitra Ravichandran was slipping in and out of consciousness but she had just one query for her son Ravichandran Ashwin when she saw him by her bedside -- "Why did you come?"
Royal Challengers Bangalore skipper Anil Kumble on Sunday described his side's nine-wicket crushing of underdogs Guyana in their opening Champions League Twenty20 match as a "perfect game" with his players coming up with an all-round show.
Ravi Shastri feels he has 'matured immensely' in the last two weeks, a period that saw dramatic developments leading upto his appointment to the high-profile job.
In the wake of Kumble's resignation though, the BCCI had specifically instructed Cricket Club of India (CCI)'s Malhotra to report any incident of discord between Kohli and Kumble when the team was in England.
Images from the Indian Premier League III match between Chennai Super Kings and Royal Challengers Bangalore at the Chinnaswamy Stadium on Tuesday.
Former Australia batsman Mike Hussey feels Adam Zampa's approach to bowling reminds him of the great Anil Kumble, even as the young leg-spinner made a strong case for his selection for the upcoming Test tour of India with some impressive performance in the sub-continent last year.
Anil Kumble scalped two wickets as Surrey beat Worcestershire by an innings and 107 runs.
Averages in the three-Test series between England and India, won 1-0 by India on Monday.
'He was fantastic on his first day at office. Even when he was not the captain he was giving inputs. It could have been a better day for him, but that's the way it is in international cricket,' said the former India captain.
With Jason Holder's men just about managing to draw the three-match ODI series against Afghanistan 1-1, there is no doubt that the current Indian team are a few notches ahead in terms of quality.
India's head coach Anil Kumble says a 'pink ball Test' in the country is "still a long way" off, even though he conceded that day/night Tests are the future to sustain interest in the longer format.
The veteran leg-spinner was left out from the one-day scheme of things after Greg Chappell took over as coach last year.
The ace Indian leg spinner is only the fifth bowler to reach the milestone.
While Vaas has moved up four places to be fourth in the ICC Player Rankings.
No praise is enough for Ravichandran Ashwin, said India captain Rohit Sharma on Wednesday as he lauded the senior off-spinner ahead of his 100 Tests, calling him a "rare" talent who has contributed consistently to the team's success.
R Ashwin is always up for a challenge and two days from his landmark 100th Test, India's premier off-spinner looked back at the on-field battles he has enjoyed in international and domestic cricket.
Royal Challengers Bangalore captain Anil Kumble held his batting colleagues responsible for the team's crushing seven-wicket defeat against Victoria Bushrangers, saying they just did not give the bowlers enough runs to defend in the Champions League Twenty20 League match. Kumble felt 127 for six on a nice batting track was just not enough and the meagreness of the total completely handicapped the bowlers.
Karnataka beat Delhi by 167 runs and claimed four points from the Ranji Trophy match.
The veteran Indian leg spinner says the selectors have promised to consider him for 'the bigger tournaments'.
Former Indian captain Anil Kumble has expressed hoped that a law the government is planning to deal with match and spot-fixing will act as a deterrent to the menace.
Anil Kumble is facing a selection conundrum as he needs to choose either "fifth bowler" Hardik Pandya or "sixth batsman" Karun Nair for the series-opener against England but India's chief coach did not reveal much on his preference, praising talent of both the players. Kumble made it clear that the team will allow Hardik to "express himself" as an all-rounder who can be the potential fifth bowler and was unequivocal about team management fully backing talented Karun if he gets an opportunity.