Nadal, playing his first match since losing to Roger Federer in the Wimbledon semi-finals, fell behind 5-2 in the tiebreak before roaring back to prevail in his first career meeting with world number 53 Evans.
Jelena Ostapenko became only the sixth female Grand Slam champion to lose in the opening round of their title defence on Sunday when she lost to Kateryna Kozlova at the French Open.
Keys and Stephens to put friendship to grand slam test
Regarded as the Oscar of sports, the nominations for 2018 Laureus World Sports Awards were finalised following a ballot by the world's sports media.
The year's final grand slam began with an upset as 13th-seeded Frenchman Richard Gasquet was upended 6-2 6-2 6-3 by Britain's world number 84 Kyle Edmund at the U.S. Open on Monday. Gasquet, who has reached the last 16 at Flushing Meadows four times in his career, was outplayed throughout and his U.S. Open experience lasted just one hour, 41 minutes.
Images from Day 2 at the US Open played at Flushing Meadows in New York on Tuesday
'This was the first time that I played points and that was too much for me today'
It was Kristyna's first win over a top-five ranked player and she will go on to play fellow Czech Barbora Strycova in the quarter-finals.
The Russian five-times Grand Slam champion struggled for rhythm initially on the low-bouncing grasscourt at the Mallorca Open but picked up the pace to beat Viktoria Kuzmova 7-6(8), 6-0.
Venus Williams accused Wimbledon officials of discriminating against its women champions and wants "equality" when it comes to scheduling matches on its two biggest showcourts.
Victoria Azarenka defeated Spain's Silvia Soler-Espinosa 6-1, 6-3 to set up a second round meeting with Jelena Jankovic.
Images from the French Open women's semi-final matches played at Roland Garros on Thursday
Fourth seed Kei Nishikori's hopes of making another magical U.S. Open run came to a quick end on Monday as last year's runner-up fell at the first hurdle, falling 6-4, 3-6, 4-6, 7-6 (6), 6-4 to Frenchman Benoit Paire.
Earlier on Wednesday, Czech Karolina Pliskova was forced to withdraw from the tournament due to a viral illness.
China's Li Na made it a hat-trick of White Group victories, overpowering back-injury victim Victoria Azarenka 6-2, 6-1 on Friday to march through to the semi-finals of the WTA Championship.
Simona Halep will take over as the new number one in the WTA world rankings after progressing to the China Open final with a dominant 6-2 6-4 victory over Latvia's Jelena Ostapenko in Beijing on Saturday.
Images from matches played on Day 5 at the Australian Open in Melbourne Park on Friday
Maria Sharapova, Serena Williams and Andy Murray were the big names to win on Monday and advance to the quarter-final of the Wimbledon.
Photos from the tennis matches played at Indian Wells on Tuesday
The All India Tennis Association (AITA) on Tuesday terminated the contract of Vijay Amritraj's Champions Tennis League due to breach of contract, much to the shock of the former star, who says the move has come at a time when they were striving to revive the League.
A season that produced the biggest shake-up in men's tennis for more than a decade draws to a close next week with three ATP World Tour Finals debutants striving to sign off breakthrough years with a large exclamation mark.
Less than a month after her run to the Wimbledon final, where she lost to Spain's Garbine Muguruza, 37-year-old Williams again had to turn back time against a young challenger.
Garbine Muguruza roared into the French Open semi-finals with a 6-2, 6-1 demolition job of Maria Sharapova on Wednesday.
Defending champion Serena Williams reached the semi-finals of the Western & Southern tournament in Cincinnati but not before having her mettle tested in a 3-6, 6-4, 6-2 win over sixth-seeded Serb Ana Ivanovic on Friday.
Multiple Grand Slam winner Sania Mirza is only 29 but the iconic sportswomen has put together the story of beating incredible odds to get to the top of the tennis world in a new book. Sania, who turned an instant sensation after she won the Wimbledon Championships girls' doubles title at the age of 16 and went on to register 41 consecutive wins with her doubles partner Martina Hingis, talks about her journey and its hardships to become the Tennis World Number One.
The weather was the number one topic of conversation at Wimbledon on Tuesday but for once it was not the prospect of rain that brought out the umbrellas but a beating sun on what was forecast to be the hottest day of the year.
French favourite Kristina Mladenovic skidded out of a storm-struck French Open on Tuesday, losing 6-4, 6-4 to Timea Bacsinszky in a rain-interrupted quarter-final in Paris.
The cute new drone that wraps itself around your wrist and also take selfies!
Images from Day 4 of the US Open in New York on Thursday.
The franchise-based Champions Tennis League, which will begin its second season next month, will help end India's search for quality singles players, its promoter and former Davis Cupper Vijay Amritraj said.
List of French Open women's singles champions:
Summary of sports events and persons who made news on Monday
Unseeded Australian Daria Gavrilova upset fifth seed Petra Kvitova, of the Czech Republic, 6-2, 6-1 in the first round of the China Open on Saturday as Serbia's Aleksandra Krunic showed stunning powers of recovery to pull off her own shock win over sixth seed Elina Svitolina.
World No 1 Serena Williams overcame a dreadful second set to beat Germany's Sabine Lisicki.
But for the 23-year-old Bouchard, a former world number five who has slumped to 56th in the rankings, it was another blow after her first-round exit in Indian Wells.
The Scot lost 6-4, 6-4 to Richard Gasquet in his first singles match since January before saying he had turned down a wild card into the men's draw at the year's final Grand Slam.
Cycling: Olympic champion Vogel stable after operation
A summary of sports events and sportspersons, who made news on Tuesday.
Eugenie Bouchard was unable to match the semi-final appearance from her maiden Australian Open last year and will now focus on sorting out her coaching arrangements after being blasted off the court by Maria Sharapova on Tuesday.
Novak Djokovic continued his Wimbledon preparations by beating American Donald Young 6-2, 7-6(9) on Thursday to reach the semi-finals of the Aegon International tournament at Eastbourne.