ManchesterCity could be without playmaker David Silva for Saturday's home game against Bournemouth while midfielder Ilkay Guendogan may make his Premier League debut.
The next man in charge faces an unenviable task trying to sort out the existing mess and then living up to goals that seem ever more distant.
A club of Manchester United's stature should be vying for silverware on all fronts, midfielder Ander Herrera said, adding that a win in the FA Cup final against Crystal Palace on Saturday would raise spirits after a poor season. Louis van Gaal's men, who finished fifth in the Premier League this campaign, failed to qualify for the Champions League for a second time in three seasons and hope to win their first trophy since taking home the Community Shield in 2013. "We have to be realistic. United should be fighting for every title. We didn't do that with the Champions League," Herrera told British media. "We didn't do that with the Premier League. So we have two options. Firstly, feel sorry for ourselves. Or, secondly, get this trophy for the fans, for our club and for ourselves."
Manchester United's unbeaten start to the Premier League has helped the club build momentum before the derby clash against ManchesterCity, striker Wayne Rooney has said.
IMAGES from EPL match played between Manchester City and Chelsea on Sunday
IMAGES from the English Premier League match played between Everton and Manchester City on Wednesday
Jose Mourinho has confirmed that record signing Paul Pogba is ready to make his second Manchester United debut when Southampton visit Old Trafford in the Premier League on Friday.
Manchester City manager Pep Guardiola has done little to quell the uncertainty surrounding Sergio Aguero's future at the club, saying that he is unsure where the mercurial Argentine striker would be plying his trade next season.
Surprise leaders Leicester City face a severe test of their Premier League title credentials over the next 10 days, starting with Saturday's trip to Manchester City.
IMAGES from the English Premier League match played on Saturday
News of all that's transpired on and off the football field
Striker Sergio Aguero says he is eager to win back his place in ManchesterCity's starting line-up and it will be up to the Premier League club to decide whether to keep him once the season ends.
Arsenal's new manager Unai Emery faces a baptism of fire after the Gunners were handed an opening day fixture at home to Premier League champions Manchester City.
Manchester United have been rejuvenated under new manager Jose Mourinho and are poised to mount a strong challenge for the Premier League title, skipper Wayne Rooney has said. The 30-year-old forward, who secured his fifth league title with the club the last time they won it in 2013, scored eight top flight goals last season as United finished fifth and failed to qualify for the Champions League.
List of major transfers in the top Premier League ahead of the 2019-20 season (all transfer fees as reported by British media):
Leicester City striker Jamie Vardy was officially presented with Guinness World Records certificate in honour of his 11 game record goal-scoring run in the English Premier League.
Sam Allardyce is the obvious candidate to replace Roy Hodgson as England manager if the FA decide to go with a home-grown candidate for the job, former Manchester United boss Alex Ferguson has said.
There will be no seismic shifts in the balance of the world's richest football competition if the first weekend of the new Premier League season is anything to go by.
Chelsea made light of striker Diego Costa's absence to extend their lead at the top of the Premier League to seven points with a 3-0 win at champions Leicester City.
Under-fire Jose Mourinho had been on the verge of delivering the perfect response to his critics on Saturday with Manchester United closing in on a second consecutive comeback win, at the home of his old club Chelsea to boot.
Images from the English Premier League matches played on Saturday.
The victory puts the pressure back on title rivals Liverpool who are at Cardiff City on Sunday and trail by a point with each side having played 34 games.
Arsenal manager Arsene Wenger has blamed his side's poor finish as the reason behind their goalless draw against Southampton in their Premier League clash at the Emirates Stadium.
Arsenal missed their chance to go back to the top of the Premier League after being forced to play with 10 men for much of the game against London rivals Chelsea on Sunday.
Manchester United forward Anthony Martial may be rested for Tuesday's Premier League trip to West Ham United to avoid aggravating a hamstring injury, manager Louis van Gaal has said.
Hull City and Swansea City earned valuable victories in their battle for Premier League survival but Middlesbrough slid further towards the drop after a 4-0 hammering at Bournemouth.
Images from the English Premier League matches played on Saturday
Antonio Conte brushed aside the praise being heaped upon him and his high-flying Chelsea team on Friday, adamant that he would not let the plaudits distract them in their surge towards the English Premier League title.
Chindu Sreedharan, PhD student in the UK, shares his experiences living abroad. He emphasises the beneficial aspects of studying abroad -- new perspectives, new people and new cultures.
It promises to be a tense and thrilling finale to the season but Liverpool, who have frittered away a seven-point lead, will need to regain their momentum quickly if they are to push for their first league title since 1990.
The Premier League kicked off in unique fashion on Saturday as an own goal by Tottenham Hotspur's Kyle Walker gave Manchester United a 1-0 victory in an undistinguished season opener at Old Trafford.
- George Best, one of the most talented footballers to grace the 'beautiful game'.
Arouna Kone grabbed a hat-trick as Everton piled on the Premier League relegation worries for Sam Allardyce's Sunderland with a 6-2 demolition job at Goodison Park on Sunday.
Liverpool made it three wins out of three as Mohamed Salah scored twice in a convincing 3-1 victory over Arsenal on Saturday to take control at the top of the Premier League.
IMAGES from the English Premier League matches played on Wednesday.
"Liverpool FC are delighted to announce that they have agreed personal terms with Danny Ings and, subject to a medical, the striker will join the club on July 1 after his contract with Burnley has expired," the club said on their website (www.liverpoolfc.com).
Third tier Peterborough United produced the performance of the FA Cup fourth round when they twice came from behind in the dying minutes to earn a 2-2 draw at Premier League West Bromwich Albion on Saturday.
Tottenham Hotspur's hopes of moving into the top four stalled in a 2-2 draw at bottom club Norwich City, while several VAR interventions overshadowed the action. Images from EPL matches played on Saturday.
Chelsea to host Burnley in Premier League season ope
David de Gea's late own goal earned Sunderland a 2-1 win over Manchester United on Saturday and a vital three points in their bid for Premier League survival.