The injury will also rule him out of the reigning European champions' two Champions League quarter-final legs against last year's runners-up Paris St Germain, scheduled for April 7 and April 13.
Real Madrid's Karim Benzema rescued his side again by scoring two late goals to snatch a 2-1 win at home to Elche in La Liga on Saturday and revive his side's hopes of catching leaders Atletico Madrid.
Pepe has blasted the Liga club's fans as "unenthusiastic", contrasting the hushed atmosphere of the Santiago Bernabeu stadium with the cauldron of noise he is now exposed to with Turkish champions Besiktas.
Olympique de Marseille were the fall guys on a hectic opening night of Europa League group stage action as German club Eintracht Frankfurt returned from the south of France with a surprise 2-1 victory on Thursday.
Images from matches played across top football leagues in Europe.
Kane began the night level on 19 goals with Liverpool's Mohamed Salah in the race for the Golden Boot.
News of all that's transpired on and off the football field.
Images from the matches played across football leagues in Europe on Sunday.
Images from soccer matches played across Europe on Saturday.
Images from Saturday's action in the Premier League.
A sloppy Real Madrid were held 0-0 at home to Real Betis on Saturday in a further blow to their hopes of retaining the La Liga title.
Images from Saturday's action in the Premier League.
Real Madrid forwards Marco Asensio and Karim Benzema struck to give their side a 2-0 win at home to Eibar in La Liga
A round-up of Friday's action in La Liga, and Bundesliga.
Liverpool's Mohamed Salah ended his Premier League goal drought in style by scoring twice as the champions raided the capital again to crush West Ham United 3-1 on Sunday.
Dortmund's Mario Goetze has suffered with muscular problems in recent months, prompting a comprehensive internal investigation into the possible causes, the club said on Monday.
Images from football matches played in Europe on Friday.
The games sounded more like Sunday kickabouts or high-intensity training sessions than the return to action of highly-paid professionals in the world's best attended football league with normally an average of about 42,000 spectators per game.
News of all that's transpired on and off the football field
Paris St Germain buried the ghosts of their embarrassing 2017 exit as they drew 1-1 at home with Barcelona on Wednesday to complete a 5-2 aggregate victory that sent them into the Champions League quarter-finals.
List of major transfers in the top Premier League ahead of the 2019-20 season (all transfer fees as reported by British media):
Germany's professional teams have been training since mid-April, divided into small groups and under strict conditions, including extensive testing of all players and coaching staff.
Heavyweights Arsenal, Atletico Madrid and Lazio took big steps towards reaching the Europa League semi-finals after convincing home first-leg victories and RB Leipzig also stayed on course with a 1-0 win over Olympique de Marseille on Thursday.
Images from the UEFA Champions League matches played on Tuesday.
Lazio, having endured a miserable start to the season, had high hopes of victory at Genoa, who were languishing in the relegation zone at the start of the day.
News of all that tranpired on and off the football field.
News of all that's transpired on and off the football field
Sarri was without Cristiano Ronaldo for the trip to the Gewiss Stadium as the Portuguese forward recovers from a knee problem ahead of Tuesday's Champions League meeting with Atletico Madrid in Turin.
Images from the football matches played across Europe on Tuesday.
Champions Bayern Munich eased past hosts Fortuna Duesseldorf 4-1 on Sunday with winger Kingsley Coman scoring twice, to go a point clear at the top of the Bundesliga.
News of all that's transpired on and off the football field.
Borussia Dortmund snatched a late goal at Atalanta to progress with a 1-1 draw, while AC Milan and Atletico Madrid, both with three-goal leads from the away legs, completed the formality of qualifying with 1-0 wins at home on Thursday.
European champions Real Madrid head to rampaging Borussia Dortmund for their Champions League Group F game on Tuesday in a frazzled state with their buoyant start to the season having been punctured by successive La Liga draws.
News of all that transpired on and off the football field
Wayne Rooney marked his 500th game in English league football with a coolly-taken Panenka-style penalty for Derby County in their 1-1 draw against Fulham in the Championship on Friday. The 34-year-old ex-England and Manchester United captain, who made his debut for the Midlands club earlier this month after returning from a playing stint in the United States, cleverly chipped in a 55th minute penalty for the lead.
News of all that's transpired on and off the football field.
News of all that's transpired on and off the football field
A summary of Sunday's action in Serie A and Bundesliga.
Portugal had to settle for a 0-0 draw at home to Spain in a heavyweight friendly on Wednesday after hammering the crossbar twice and missing a last-gasp open goal.
Images from football action around European leagues played on Sunday