Mourinho's tinkerings meant a first start of the season for midfielder Scott McTominay, playing on the right of a three-man defence, while Anthony Martial played instead of the dropped Alexis Sanchez. On this evidence, more changes may be needed when United take on Valencia in the Champions League on Tuesday.
There was no dearth of praise for little magician Lionel Messi who struck his 500th goal for FC Barcelona on Sunday.
News of all that's transpired on and off the football field
Chelsea need to improve a lot before they could be considered Premier League title contenders, manager Antonio Conte has said after his resurgent side beat Southampton 2-0 on Sunday.
The switch to centre-forward has also seen Ronaldo overtake Jimmy Greaves as the top goalscorer in Europe's top five leagues with 368 goals between the Premier League and La Liga, while also passing the milestones of 400 goals for Real and 100 Champions League strikes.
Pep Guardiola's formidable managerial skills will be put to the test again when his stuttering ManchesterCity side visit his former club Barcelona in a top-of-the-bill Champions League clash on Wednesday.
Seconds after Bournemouth had a chance to snatch victory the ball went back down the other end and Sterling's deflected shot looped past helpless Bournemouth keeper Asmir Begovic.
Wenger dropped Rob Holding for the visit to Stoke, preferring Shkodran Mustafi alongside Nacho Monreal and Sead Kolasinac at the back.
Brendan Rodgers has ruled Liverpool out of the Premier League title race this season, although he believes his side will play a part in deciding where the trophy ends up.
Leaders Manchester City kept up their unbeaten run with a 3-1 win over Bournemouth on Saturday. Manchester United salvaged a 2-2 draw at Southampton, who sacked manager Mark Hughes on Monday.
Chelsea manager Antonio Conte was fuming at the final whistle after Pedro and Alvaro Morata were dismissed in extra time and two penalty appeals had been waved away, but the Premier League champions regained their composure to win the shootout 5-3.
De Rossi, who turned 36 on Wednesday, led Roma for the final time in a 2-1 victory over Parma at the Stadio Olimpico in May and finished his stint in the Italian capital with 616 appearances in 18 years.
Barcelona will travel to Borussia Moenchengladbach for their Champions League match on Wednesday without Lionel Messi but the Spaniards have enough options and firepower to plug the gap left by the Argentine, coach Luis Enrique said.
Sanchez, 28, is currently in the final year of his contract. He has been linked with a move to Paris St Germain in the current transfer window.
Mourinho has a reputation for creating a siege mentality at the clubs he manages, and he has used the injury crisis -- which saw top scorer Zlatan Ibrahimovic and key defender Marcos Rojo suffer serious knee injuries last week - to create a spirit of resistance amongst his current squad.
Images from the EPL matches played on Sunday
'I want to say I was convinced even before (the defeat by Chelsea in February's FA) Cup match that controlling the two players that play behind Diego (Costa) and controlling the full-backs, because they go really deep with two wide men, would create lots of problems and I repeat the same'
Goals from Adam Lallana and Roberto Firmino put the home side ahead by halftime and they romped to victory with a Giannelli Imbula own goal and Daniel Sturridge strike after Stoke threatened an upset with a Jonathan Walters header.
Sweden captain Zlatan Ibrahimovic hinted on Sunday at a move to the Premier League and promised big things to come in his career.
Substitute Ki sung-Yueng drove in an extra-time winner to take the Premier League's bottom club Sunderland into the League Cup semi-finals with a dramatic 2-1 victory over Chelsea on Tuesday.
Photos from the English Premier League match played between Manchester United and Arsenal on Saturday
The pain of missing out on a first domestic league crown for 29 years will be eased by the knowledge that European glory could be on the horizon for Liverpool
'It was a great atmosphere, I am so pleased for all of the people who have had harder times with us this season'
English soccer player Adam Johnson, who was sacked by Premier League club Sunderland last month, was facing jail after being found guilty on Wednesday of sexual activity with a 15-year-old girl.
Manchester United have shown they are capable of playing an attractive and attacking brand of football in their recent games, midfielder Juan Mata said after Sunday's 1-1 Premier League draw at his former club Chelsea.
Summary of sports events and persons who made news on Friday
A fixture that once enjoyed the cachet of a heavyweight title fight -- and often resembled one on the pitch as England's preeminent teams slugged it out -- has been relegated in status with United fifth and Arsenal sixth in the Premier League.
Galatasaray win 22nd Turkish title after beating closest rival
Sergio Aguero, in fine scoring form for Manchester City this season, looks set to lead Argentina's attack in next month's World Cup qualifiers after being recalled to their squad on Friday.
A summary of sports events and sports persons, who made news on Tuesday
Former Manchester United striker Andy Cole is recovering in hospital after undergoing a kidney transplant, the club said in a statement on Friday.
From Cristiano Ronaldo picking up the third Golden Boot award of his career to Phoenix Suns cheerleaders, Rediff.com has it all snapped right here...
Goals from Curtis Davies and Robert Koren earned HullCity a place in the FA Cup quarter-finals with a 2-1 replay win at home to Brighton and Hove Albion on Monday.
Arsenal manager Arsene Wenger spoke last week of his desire to keep the 24-year-old Oxlade-Chamberlain, who was also a target for champions Chelsea.
Manchester United maintained their push for a top-four Premier League finish when they beat Everton 1-0 with a second-half goal by French striker Anthony Martial at Old Trafford on Sunday.
Images from the English Premier League matches played on Tuesday
Cardiff had lost six of their previous seven games but, knowing that anything but a victory would probably end their survival hopes after one season in the top flight, overcame a strong Brighton start to play with growing confidence and fully deserved their victory.
News of all that's transpired on and off the football field
Jose Mourinho will be appointed Manchester United manager next week to replace Louis van Gaal despite Saturday's FA Cup final victory over Crystal Palace, British media have reported.
The London club dominated the first half but fell behind to a superb goal from their former winger Aaron Lennon before young midfielder Dele Alli furthered his case for a place in England's midfield with a classy equaliser just before the break.
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