Ronaldo's replacement Dybala scored in the 77th minute with a goal the Portuguese would have been proud of. After a quick exchange of passes, the Argentine twisted past Alessio Romagnoli and beat Gianluigi Donnarumma with a right foot shot.
Monaco's firepower was far too hot to handle for Olympique de Marseille as the Principality side moved top of the French Ligue 1 standings with a 4-0 home win on Saturday.
Robert Lewandowski struck twice in the first half as holders Bayern Munich cruised past Schalke 04 3-0 on Wednesday to reach the German Cup semi-finals.
Barcelona took a big step towards the Champions League semi-finals.
Paris St Germain would be odds-on certainties to easily beat Chelsea and take a big step towards the Champions League quarter-finals on Tuesday if statistics and domestic form decided matches.
Images from the Champions League matches played on Tuesday
Ten of the 16 sides also reached the same round two seasons ago and, as usual, the big five leagues dominate with 13 clubs hailing from either the English, Spanish, German, French and Italian leagues.
News of all that's transpired on and off the football field
Diego Costa continued his rich vein of form as he helped leaders Chelsea to a 3-0 win over Aston Villa while Louis van Gaal enjoyed only his second Premier League win as Manchester United manager following a 2-1 victory against West Ham.
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field.
Photographic summary of the football matches played across Spain, Italy and France
All the latest football news from around Europe.
Reigning French Open champion Maria Sharapova, former world number one Venus Williams and Australian Samantha Stosur sailed into the second round of the China Open with straight set victories on Sunday.
Photos from the Champions League matches played across Europe on Tuesday.
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