Djokovic spent much of the third-round encounter cruising on auto-pilot
Somdev Devvarman struggled past Japanese qualifier Taro Daniel to progress to the singles quarter-finals of the ATP Challenger tournament, in Charlottesville, US.
Twice champion Rafa Nadal and triple winner Roger Federer barely raised a sweat as they each cruised into the third round of the Indian Wells ATP tournament with imperious victories on Sunday.
Leander Paes regained his place in the top-50, courtesy a Challenger title win at the Newport Beach event. The triumph took the veteran Indian tennis star 14 places up, to 47 in the latest rankings, issued on Monday.
So Djokovic will certainly not be letting his guard slip when he plays American Denis Kudla on Friday.
Russia's Daniil Medvedev defeated Benoit Paire of France 6-3, 6-4 in the first round of the Abierto Mexicano tournament in Acapulco on Tuesday to get his quest for the world number one ranking off to a winning start.
British No 1 Cameron Norrie overcame a slow start to beat Frenchman Hugo Gaston 6-3, 7-5.
India's miserable campaign at the Wimbledon ended as defending mixed doubles champions Leander Paes and Martina Hingis were knocked out in the third round by scratch pair of Britain's Heather Watson and Finland's Henri Kontinen, who played their first match together.
Djokovic struggled with both his serve and backhand during a 6-4, 7-6(3), 6-1 win over Argentine Juan Ignacio Londero and later said his left shoulder had been bothering him for weeks with the pain getting worse during the match.
Top seed Alexander Zverev crashed out in the second round of the Stuttgart Open, losing to world number 170 Dustin Brown.
Serena Williams moved another step closer to a record-tying 24th career Grand Slam title with a comfortable 6-3, 6-2 victory over Czech Karolina Muchova on Friday to reach the last 16 at the US Open.
It was Novak Djokovic's first match this year after his Australian Open hopes were dashed when he was deported following an 11-day saga revolving around his decision not to have a COVID-19 vaccination.
IMAGES from Day 5 of the Wimbledon Championships at All England Lawn Tennis and Croquet Club on Friday.
Roger Federer was made to work hard by Fernando Verdasco before beating the Spanish veteran 6-3, 3-6, 6-3 on Wednesday to reach the quarter-finals of the Dubai Duty Free Tennis Championships.
Seven-time champion Serena Williams endured an unlikely scrap in her Wimbledon opener and will look to shake off more rust in the second round on Thursday when she faces another qualifier in 18-year-old Kaja Juvan.
Murray, who is attempting to return to the top of the tennis world after undergoing hip surgery in January, was out of sorts in the first set of the rain-delayed match, losing three service games behind some uncharacteristically soft second serves.
Young Indian golfer Aditi Ashok notched up her second successive top-10 finish by finishing tied-sixth at the Volunteers of America LPGA Texas Classic, in Texas.
Summary of sports events and persons who made news on Monday
A summary of the action on Day 3 at the US Open.
Unseeded Novak Djokovic was given some trouble by Jeremy Chardy in the opening set but prevailed 7-6(5), 6-4 to take his record over the Frenchman to 11-0 and 26-0 in sets.
Will it be Rafa versus Djoko in Sunday's final?
Images from matches played on Day 4 at the US Open at the Flushing Meadows in New York on Thursday.
Second seed Sloane Stephens was shocked 2-6, 6-4, 6-2 by Germany's Andrea Petkovic in the second round of the Citi Open on Wednesday, disrupting the American's buildup to her US Open title defence.
Top seed Serena Williams turned an early challenge into an eventual cakewalk as she beat Russian-born Yulia Putintseva 7-6(2), 6-0 in the third round of the BNP Paribas Open in California on Sunday.
A summary of sports events and persons who made news on Thursday.
Cilic marches past Querrey into Queen's semis
Former world number one Garbine Muguruza was beaten 7-5, 6-4 by Aryna Sabalenka in the China Open second round on Tuesday while an ailing Jelena Ostapenko lost 6-0, 6-0 to Wang Qiang.
Images from matches played on Day 4 of the Australian Open at Melbourne Park on Thursday
Images from the third day at the US Open, the final Grand Slam tournament of the year, in New York, on Wednesday:
Images from Day 3 of the 2016 Australian Open in Melbourne, on Wednesday