Debutant Helder Costa opened the scoring on his international debut for an experimental Portugal who made 10 changes from the team which started the 3-2 Nations League win in Poland on Thursday.
Marcus Rashford's penalty and a deflected strike from Mason Mount helped England come from a goal down to overcome top-ranked Belgium 2-1 at Wembley on Sunday and climb above them in their UEFA Nations League group.
Portugal became the first team to qualify for the Nations League semi-finals when they held Italy 0-0 on Saturday, the second time in a year that the hosts have been knocked out of a competition following a goalless draw at the San Siro.