The Indo-American pair went down 6-7, 7-5, 10-4 to Yan Zi and Zheng Jie of China in the semi-final of the Indian Wells tournament.
World number one Roger Federer reached the last four of the Pacific Life Open without hitting a shot on Friday when his quarter-final opponent Tommy Haas pulled out with a sinus infection. Swiss Federer, three times champion at Indian Wells and seeking his first ATP title of the year, will next meet unseeded American Mardy Fish, who scraped past seventh-seeded David Nalbandian of Argentina 6-3, 6-7, 7-6.
Spaniard Rafael Nadal stayed on course for his first ATP title of the year with a 6-1 6-3 demolition of American wildcard Donald Young in the Pacific Life Open. Ninth-seeded American James Blake powered past Spaniard Carlos Moya 6-3 6-4 to set up a fourth-round clash with Richard Gasquet of France.
The top seed crushed Spaniard Guillermo Garcia-Lopez 6-3, 6-2 in a second-round encounter at the Pacific Life Open.
The Australian Open champion believes Roger Federer's top ranking is under threat from himself, second-ranked Nadal and fourth-ranked Russian Nikolay Davydenko. Djokovic, who piled up five ATP titles in 2007, has targeted another year of consistent performances and wants to produce his best form in the big events.
The Russian claimed her second title of the year when she defeated unseeded Vera Zvonareva 6-1, 2-6, 6-0 in an all-Russian final in Doha.
I physically feel very fit. I'm very motivated to keep on playing on a very high level, says Novak Djokovic.
Sania Mirza staged a strong comeback to beat ninth seed Shahar Peer of Israel and enter the fourth round of the Pacific Life Open in Indian Wells on Sunday. The Indian ace won 6-7, 7-5, 6-3 and will next face defending champion Daniela Hantuchova of Slovakia in the Tier-I event.
The fifth seeds defeated fourth seeded Paul Hanley and Kevin Ullyet 6-3, 7-6 (4).
A summary of Novak Djokovic's rise in the tennis circuit in photos.
Serena Williams stayed on course for a fourth Sony Ericsson Open title with a ruthless 6-1 6-4 win over Czech Nicole Vaidisova in the quarter-finals on Wednesday.
However, Mahesh Bhupathi and his Czech partner Radek Stepanek were ousted by the French duo of Julien Bennetean and Richard Gasquet at the Pacific Life Open.
The 20-year-old was ruled out of action for at least four weeks after undergoing surgery on her right knee.
They went out of the title race at Rome Masters series following their loss to the sixth-seed pair of Fabrice Santoro and Ninad Zimonjic.
Sania Mirza savoured a historic 2015 as she became the first female player from India to win a women's doubles Grand Slam title on way to becoming World No 1 even as Yuki Bhambri presented himself in a new 'avtar', raising hopes on the otherwise barren singles circuit.
Leander Paes' impressive show at the ATP Masters has seen him rise four places to eighth in the latest doubles rankings.
The Serb beat Guiilermo Canas 6-3, 6-2, 6-4 in the final of the Miami Masters on Sunday.
Argentine Guillermo Canas tamed big-hitting Croat Ivan Ljubicic 7-5 6-2 to reach the final of the Sony Ericsson Open on Friday, underlining his return to top form following a 15-months doping ban.
The Indo-Czech duo beat Austria's Julian Knowle and Jurgen Melzer 6-4, 6-7 (1), 10-6 over in the second round.
The Indo-Czech duo beat Jonas Bjorkman and Max Mirnyi to enter the final of the Pacific Life Open tennis tournament.
The fifth seeds beat Poland's Mariusz Fyrstenberg and Marcin Matkowski 6-3, 7-5 in a second round early morning match.
Martina Hingis cruised but top seed Maria Sharapova had to work a little harder to secure opening victories at the Pacific Life Open.
The Russian beat unseeded Katarina Srebotnik of Slovenia in the semi-finals of the Zurich Open.
India's Sania Mirza and her partner Martina Hingis staged a superb comeback to clinch the women's doubles title after a thrilling victory against Russian duo of Elena Vesnina and Ekaterina Makarova in the final, on Saturday.
The Serb's dominance in 2016, says Bikash Mohapatra/Rediff.com, is way beyond numbers. It's about how he forced his opponents into submission.
The sixth seeded Indo-Czech pair failed in their bid to won back-to-back Masters titles, in Miami on Saturday.
In-form Victoria Azarenka battled past an ailing but determined second seed Angelique Kerber to set up a Miami Open final showdown against Svetlana Kuznetsova with a 6-2, 7-5 victory on Thursday.
The US Open champion claimed her fourth title of the year on Sunday by beating unseeded Hantuchova 6-1, 4-6, 6-3.
Serena Williams brushed off some serving troubles before cruising to a 6-4, 6-3 win over Elina Svitolina on Saturday and will meet Simona Halep in the Western & Southern Open final.
An almost deathly hush descended as Serbian Novak Djokovic administered the last rites on Rafael Nadal's reign of dominance at the French Open.
The Russian feels she is in much better shape than when she won the 2004 Wimbledon crown at the age of 17.
World number two Maria Sharapova, a stunning second-round loser at Wimbledon last month, has taken on eight-time Grand Slam winner Jimmy Connors as her new coach.
The world No.1 maintained his stranglehold over the Croat to lift his second straight Nasdaq-100 Open title.
Roger Federer lost his first tiebreak this year before beating Arnaud Clement as he began his title defence at the Nasdaq-100 Open.
Factbox on Serbia's Novak Djokovic and Great Britain's Andy Murray who will contest his sixth Australian Open men's singles final on Sunday.
The Indian ace fought off a strong challenge from qualifier Bethanie Mattek at the Pacific Life Open.
In women's action, comeback queen and former world number one Martina Hingis beat Austria's Sybille Bammer at the Pacific Life Open.
They beat Antonella Serra Zanetti of Italy and Stephanie Foretz of France in the first round of the Pacific Life Open.