Saturday's clash between Manchester United and Tottenham Hotspur at Old Trafford is already shaping up as an early-season eliminator to challenge runaway leaders Manchester City for the Premier League title.
Seasonal cheer has been scarce for Louis van Gaal after a six-match winless sequence for his Manchester United side intensified rumours that he will be sacked and Stoke City are unlikely to be offering any solace on Saturday.
'It's very difficult to play football in these circumstances within 48 hours. It's amazing for the fans around the world, everybody has the Premier League, I'm more than happy to do that but it's very hard for the players'
'Before the start of the season I felt Manchester United will be a lot better this year and they were my tip for the title'
Mauricio Pochettino's Tottenham Hotspur can cement their status as the top dogs in the capital if they end an eight-year wait and defeat Arsenal in the North London derby on Sunday.
Jamie Vardy wrote a new chapter in his fairytale rise from the wilderness of non-League football to playing for England, when he became the first player to score in 11 consecutive Premier League matches on Saturday.
Currently, players from outside the EU must gain work permits and pass a series of qualification tests to get a "governing body endorsement" and work permit.
Brighton and Hove Albion's Tomer Hemed grabbed the only goal as they ended Newcastle United's three-match winning streak with a 1-0 victory on Sunday in a battle between two of this season's promoted sides.
Huddersfield Town were left celebrating wildly after securing their Premier League safety on Wednesday with a dramatic and resilient 1-1 draw at Chelsea, a result that looks almost certain to condemn Swansea City to relegation.
Manchester United manager Jose Mourinho has dismissed suggestions that midfielder Paul Pogba faces a lengthy lay-off because of a hamstring injury sustained in the Champions League defeat of Basel on Tuesday.
Swansea City's hopes of salvaging their place in the Premier League suffered a potentially grievous blow as Ryan Fraser's deflected strike earned Bournemouth a 1-0 win on Saturday to secure another season of top-flight football for the Cherries.
Chelsea replaced Liverpool at the top of the English Premier League with a 1-0 victory at Middlesbrough.
Arsene Wenger's final match at Old Trafford as Arsenal manager ended in defeat with a stoppage time header from substitute Marouane Fellaini earning the points for second-placed Manchester United.
Top-class goals from Bernardo Silva and Sergio Aguero took Manchester City back to the top of the Premier League in a 2-0 win over Fulham at Craven Cottage on Saturday.
Tottenham Hotspur have shown impressive durability in the Premier League lately, but they will need to be at their most steadfast to deny champions and league leaders Manchester City who travel to Wembley on Monday.
Romelu Lukaku's 50th league goal for Everton put them on the way to a deserved 2-0 victory over West Ham United on Sunday, ending a run of four league games without a win. It kept the Merseysiders sixth in the Premier League and West Ham in the bottom five.
'The mental level, the day by day, everything must be consistent until the last day so one of the things we have to improve is consistency'
Chelsea ended their slump with a win over Arsenal while seemingly invincible Manchester City lost their 100 per cent record to West Ham United on a day of contrasting fortunes for the Premier League title favourites on Saturday.
Leicester City manager Claudio Ranieri has asked for a change in mentality to revive the club's Premier League campaign which is in stark contrast to their impressive Champions League form.
Tottenham Hotspur claimed a first victory at Chelsea for 28 years with Dele Alli scoring twice in the second half as they came back to win 3-1 and cement fourth place in the Premier League on Sunday.
Manchester United battled back from two goals down to beat Newcastle United 3-2 at Old Trafford on Saturday as a 90th-minute winner from Alexis Sanchez completed a spirited comeback to ease the pressure on manager Jose Mourinho.
Liverpool manager Juergen Klopp acknowledged that they would have to defend better in the visit to Stamford Bridge to stop Eden Hazard reprising the sort of solo brilliance that propelled Chelsea to victory at Anfield on Wednesday.
Chelsea goalkeeper Kepa Arrizabalaga remains the club's first choice but manager Maurizio Sarri is still uncertain if the Spaniard will be recalled to the starting team for Sunday's Premier League trip to Fulham.
I don't think we can do a Leicester. I am realistic, says Everton manager
Chelsea lost their 100 per cent Premier League record when London rivals West Ham United held them to a 0-0 draw on Sunday.
Chelsea have completed the signing of Basel's Egyptian winger Mohamed Salah, the Premier League club said on their website on Sunday.
Images from the English Premier League matches played on Saturday
The centre-back has not played since Sarri took over from Antonio Conte at the start of the season, and says he could call time on his career at Stamford Bridge when the transfer window reopens if his situation does not improve.
Images from the English Premier League matches played on Tuesday
Liverpool took over at the top of the Premier League table despite being held to a 0-0 draw against Manchester United in a scrappy match on Sunday.
IMAGES from the English Premier League matches played on Saturday
Liverpool continued their perfect start to the season to stay top of the Premier League after a goal in each half gave them a 2-1 victory over Tottenham Hotspur at Wembley on Saturday.
The north London outfit were brushed aside by a dominant City side in last Sunday's League Cup final with Pep Guardiola's team converting all three of their shots on target to win 3-0 while Arsenal failed to convert either of their chances.
Tottenham went ahead through Sanchez who scored his first goal for the London club by meeting Eriksen's whipped cross with a diving header in the 33rd minute, although Leicester's players complained he was in an offside position.
Romelu Lukaku struck twice as Manchester United returned to winning ways after two successive Premier League losses with a 2-0 victory over Burnley at Turf Moor on Sunday.
Champions Manchester City will expect to get back to winning ways at home to Newcastle United in a match which pits Pep Guardiola against his fellow Spaniard Rafa Benitez.
Manchester United will be without world record signing Paul Pogba for their Premier League opener against Bournemouth on Sunday due to a suspension, the Football Association said on Friday.