The victory puts the pressure back on title rivals Liverpool who are at Cardiff City on Sunday and trail by a point with each side having played 34 games.
Tottenham Hotspur reached the semi-finals of the Champions League on away goals after a 4-3 (aggregate 4-4) defeat to Manchester City in a breathtaking quarter-final second leg game on Wednesday.
Match-by-match facts and statistics ahead of round 11 of the Premier League on Nov. 3-5:
Images from the English Premier League matches played on Sunday
IMAGES from the English Premier League matches played on Wednesday
A round-up of Saturday's matches in the English Premier League.
Ten-man Manchester City staged a dramatic comeback with late goals from Leroy Sane and Raheem Sterling securing them a 3-2 win at Schalke 04 in their Champions League Round of 16 first leg.
Premier League leaders Manchester City turned on the style with a 3-1 win over Manchester United in their derby clash, on Sunday, leaving Pep Guardiola's unbeaten side two points clear of Liverpool.
This and more from the happenings in the world of football
Ole Gunnar Solskjaer continued his dream start as Manchester United caretaker manager with a 3-1 Premier League win over Huddersfield on his Old Trafford debut in the dugout on Wednesday.
Hegerberg hat-trick fires Lyon to fourth straight Champions League
A round-up of Wednesday's league stage matches in the UEFA Champions League.
Manchester City advanced to the Champions League quarter-finals despite suffering their first home loss in over a year, going through 5-2 on aggregate after a 2-1 defeat by Swiss champions Basel on Wednesday.
Manchester City claimed the win required to finally end Liverpool's relentless attempt to dethrone them as Premier League champions as they hit back from a goal down to crush Brighton and Hove Albion on the south coast on Sunday.
Five-times European champions Barca, with their trident of Lionel Messi, Luis Suarez and Neymar subdued, have not exited in the last 16 since going out to Liverpool in the 2006/07 season and the score equalled their worst Champions league loss.
Bayern Munich booked their fifth successive Champions League semi-final spot with a 2-2 draw at Benfica on Wednesday to seal a 3-2 aggregate victory that kept the Germans on course for a treble of titles.
Manchester City have signed French central defender Aymeric Laporte from Spanish club Athletic Bilbao, the Premier League leaders said on Tuesday.
Images from EPL matches played on Tuesday
A summary of all the Champions League matches played across Europe on Wednesday
Barcelona's Luis Suarez netted twice for a 2-1 win over 10-man Atletico Madrid in their Champions League quarter-final, first leg on Tuesday after the visitors' Fernando Torres opened the scoring and was later sent off.
Following is a match by match look at the English Premier League's season-opening weekend fixtures:
Robert Lewandowski scored a brilliant free kick to give Bayern Munich a 1-0 win over Atletico Madrid in their last Champions League Group D outing on Tuesday, ending the 100 percent record of their opponents. The Poland international curled the ball over the wall and into the corner of the net in the 28th minute but the goal had no impact on the final standings with Atletico guaranteed top spot and Bayern in second place.
A summary of Tuesday's group matches in the UEFA Champions League.