Holders Napoli, already reeling after being deduced two Serie A points for match-fixing, were knocked out of the Italian Cup last 16 after suffering a last-gasp 2-1 home defeat by Bologna on Wednesday.
Napoli kept in touch with Serie A leaders Juventus with a 5-1 thumping of bottom club Pescara on Sunday while Inter Milan scraped a 1-0 win over Palermo.
Luis Suarez ended his nine-match biting ban in fine style on Friday, grabbing the second-half equaliser that gave Uruguay a 2-2 draw in an enthralling battle with Brazil in the 2018 World Cup qualifiers.
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Manchester United moved three points clear at the top of the Premier League after a Paul Pogba goal gave them a hard-fought 1-0 win over Burnley at a freezing Turf Moor on Tuesday.
Atletico Madrid fell to their heaviest league defeat of the season
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Ezequiel Lavezzi and Edinson Cavani combined to spark Napoli's 3-1 comeback win over Chelsea in their Champions League last 16 first-leg match on Tuesday that deepened the gloom hanging over the London club.
Napoli won their first major title since the Diego Maradona era, denied Serie A champions Juventus the double and handed their captain Alessandro Del Piero an unhappy end to 19 seasons at the club by beating the Turin side 2-0 in the Italian Cup final on Sunday.
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Uruguay's Cristian Rodriguez scored a soft goal in the holders' laboured 1-0 win over outsiders Jamaica when they opened their defence of their Copa America title on Saturday.
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Javier Pastore's double inspired a weary Paris St Germain to a 3-1 win at Nice as the French champions reclaimed top spot in Ligue 1 on Saturday.
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Brazil forward Neymar denied he had problems with his team mates at his club Paris St Germain and was moved to tears after being given the backing of his national team coach Tite.
Images from the FIFA World Cup qualifiers matches.
Should the Portugal forward triumph, he will equal the record of his great rival and five-time winner Lionel Messi of Barcelona, who is also nominated.
A summary of Wednesday night's action in the UEFA Champions League.
An early goal by Guingamp's Jeremy Pied was enough to hand champions Paris St Germain their first loss of the French Ligue 1 season, leaving Olympique de Marseille still on top despite their own defeat by Monaco on Sunday.
Zlatan Ibrahimovic, facing multiple suspensions, struck twice to lift Paris St Germain to a crushing 4-0 victory over Bastia.
Lionel Messi, Luis Suarez and Neymar combined to devastating effect as Barcelona swatted Celtic aside 7-0 at the Nou Camp to lay down a marker in Champions League Group C on Tuesday.
Cristiano Ronaldo scored the 750th goal of his remarkable career in a 3-0 win over Dynamo Kyiv on Wednesday
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Chelsea, Bayern Munich, Real Madrid and Juventus consolidated their top-flight leads at the weekend while Paris St Germain proved too strong for Ligue 1 leaders Olympique Marseille.
A summary of all the Champions League matches played across Europe on Tuesday
Antonio Cassano scored his first AC Milan goal and Robinho struck twice to help the Serie A leaders end a run of two straight draws in a 4-0 home thrashing of Parma on Saturday.
Substitute Giampaolo Pazzini scored twice and won a penalty on a dream debut as Serie A champions Inter Milan roared back from 2-0 down to beat visiting Palermo 3-2 in an enthralling encounter on Sunday.
Harry Kane toppled Alan Shearer's 22-year-old record for the most Premier League goals in a calendar year by scoring a double for Tottenham Hotspur against Southampton, on Tuesday, also overtaking Lionel Messi as the top scorer in Europe.
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Raphael Varane's glancing header and a goalkeeping blunder that gifted Antoine Griezmann a soft goal gave France a 2-0 victory over Uruguay in the first World Cup quarter-final on Friday and a set up a last-four tie with Brazil or Belgium.
Arsenal manager Arsene Wenger used to dream about Luis Suarez, the signing that got away, and he will be hoping the Uruguayan striker doesn't give him nightmares when holders Barcelona visit in the Champions League on Tuesday.
Serie A leaders AC Milan slipped up for the second straight game in a 1-1 draw at Genoa on Sunday which opened the door for Napoli to cut the gap at the top to three points.
Neymar and Mbappe satins are Paris fashion must-haves.
Paris St Germain's then sports director Leonardo declared the club were ready for tougher competitions in Europe two years ago but Tuesday's Champions League quarter-final exit suggests PSG need more time to reach the top.
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Colombia reached the quarter-finals of the World Cup for the first time after a double from James Rodriguez gave them a 2-0 win over Uruguay in Rio de Janeiro on Saturday.
Uruguay crushed Ecuador 4-0 in their Copa America opener on Sunday with help from an early sending off that deflated their opponents and assured the 15-times champions the simplest of starts to their campaign.
Juventus lost their first Serie A game of the season when a pumped-up Palermo sealed a comfortable 2-0 home win on Sunday.
Real have underperformed on the domestic stage, trailing Barcelona by 15 points and knocked out of the King's Cup by Leganes, and many predicted an early elimination from Europe when they drew the runaway Ligue 1 leaders in the last 16.
Mexico scored twice in the final five minutes to beat Uruguay 3-1 in a pulsating Copa America Group C match in which each side had a man sent off on Sunday.