Aston Villa were relegated from the Premier League for the first time since it began in 1992 when they suffered their 24th loss of the season in a 1-0 defeat at Old Trafford on Saturday.
The victory puts the pressure back on title rivals Liverpool who are at Cardiff City on Sunday and trail by a point with each side having played 34 games.
Veteran striker Kevin Phillips scored an extra-time penalty as Crystal Palace ended an eight-year Premier League absence by beating Watford 1-0 in the Championship (second tier) playoff final at Wembley on Monday.
Top-class goals from Bernardo Silva and Sergio Aguero took Manchester City back to the top of the Premier League in a 2-0 win over Fulham at Craven Cottage on Saturday.
City are two points behind leaders Liverpool, but have a game in hand
Manchester City moved back into third place and almost guaranteed Champions League qualification thanks to a 3-1 home victory against West Bromwich Albion on Tuesday at the Etihad Stadium.
Cavani suspended by FA for three games over use of racial term
Roma teenager Afena-Gyan plays down apparent racist remark.
Chelsea's new signing Gonzalo Higuain netted his first two Premier League goals in Chelsea's 5-0 thrashing of Huddersfield Town while Tottenham Hotspur's Son Heung-min struck late for a 1-0 win over Newcastle United as they moved into second place.
Professional sportpersons including Lewis Hamilton and Raheem Sterling have become leading voices in the anti-racism movement amid protests over the death of George Floyd, an unarmed black man in police custody in Minneapolis.
English Premier League leaders Liverpool opened up a 22-point gap at the top of the table with second-half goals from Alex Oxlade-Chamberlain, Jordan Henderson and a Mohamed Salah brace giving them a 4-0 home win over Southampton. A rare double from defender Antonio Rudiger earned Chelsea a point in an entertaining 2-2 draw with third-placed Leicester City.
West Ham United's Michail Antonio has come to the defence of teammate Kurt Zouma, who has been targeted by fans for abusing his cats.
Liverpool boss Juergen Klopp has beaten Manchester United only twice in his career and never at Old Trafford -- his worst record against any Premier League side.
English Premier League soccer clubs on Wednesday voted unanimously to return to contact training, including tackling, as the English top flight moved a step closer to a resumption after the shutdown caused by the novel coronavirus pandemic. No matches have been played in the Premier League since March when the coronavirus pandemic shut down world sport.
"Diego Costa's out which means we have to solve that problem in 24 hours," new interim coach Guus Hiddink told reporters.
Match-by-match facts and statistics ahead of the Premier League fixtures on April 28-30
Holders Manchester City began their assault on the FA Cup with a 4-1 victory over fourth-tier Port Vale but Manchester United and Wolverhampton Wanderers face an unwanted replay after drawing 0-0 at Molineux on Saturday. Goals from Oleksandr Zinchenko, Sergio Aguero, Taylor Harwood-Bellis and Phil Foden made it a routine day for City, although Tom Pope had equalised for a Vale side sitting 74 places lower in the standings.
Watford manager Nigel Pearson warned that players lives could be in danger if the Premier League returns too soon.
Watford goalkeeper Ben Foster says it would be wrong for English Premier League players to be tested for the coronavirus ahead of medical workers as plans for Project Restart continue. Twice weekly tests for Premier League players are part of the plan to resume the Premier League next month after it was suspended in March because of the pandemic.
Liverpool face Spurs in the game of the weekend, a day after title rivals Manchester City travel to struggling Fulham.
Raheem Sterling scored a second-half hat-trick as leaders Manchester City beat Watford 3-1 on Saturday while Liverpool kept the gap at one point by overcoming Burnley 4-2 on Sunday.
Manchester won the English Premier League, the English League Cup and FA Cup this season
Raheem Sterling scored a hat-trick as champions Manchester City made a convincing start to their title defence with a 5-0 win over West Ham United.
Photos from the English Premier League matches played on Sunday
News of all that's transpired on and off the football field
Images from the English Premier League matches played on Saturday
A Bournemouth player was one of two people working for English Premier League clubs who tested positive for coronavirus following a second batch of testing, the club said on Sunday. Bournemouth did not disclose the player's identity but said he would self isolate for seven days in line with league protocols before another test is conducted.
News of all that transpired on and off the football field
Rediff.com brings a preview of the main matches coming up this weekend in the English Premier League.
Liverpool captain Jordan Henderson insists he has felt "very safe" since his club returned to training amid the coronavirus crisis
Rafael van der Vaart's speculative long shot just before halftime sent Tottenham Hotspur into the FA Cup fifth round with a fortunate 1-0 win at Watford on Friday.
News of all that transpired on and off the football field.
Images from the English Premier League matches played on Saturday
News of all that transpired on and off the football field
A preview of the line-up action in the English Premier League from October 20-22.
Images from the English Premier League matches played on Tuesday.
Leaders Chelsea stretched their Premier League winning run to a club record-equalling 11 as Diego Costa's header shortly before halftime secured a 1-0 victory at London rivals Crystal Palace on Saturday.
Following is a match by match look at the English Premier League's weekend fixtures:
The win moved Spurs up to third but unbeaten Manchester City still looked in a class of their own at the top as Leroy Sane scored twice in a 4-0 stroll over West Ham United.
The brilliance of Chelsea's Eden Hazard ended Liverpool's 100 percent start to the season as Maurizio Sarri's side enjoyed a 2-1 win at Anfield in the League Cup third round on Wednesday.