It was the former world number one's earliest loss at Wimbledon since she went out in the opening round on her debut here in 1997.
Seven-times Grand Slam winner Venus Williams has withdrawn from this month's Australian Open saying she is not ready to return to action after being sidelined because of health reasons.
Injury-hampered Venus Williams made a first-round exit at the Dubai Open on Monday.
Venus Williams beat local favourite Kim Clijsters 6-2, 6-3 to reach the semi-finals of the Antwerp Diamond Games tournament.
Confident Venus Williams has her heart set on a glittering prize at this week's Antwerp Open.
Venus Williams proved she was still a force to be reckoned with after a two-year battle with injuries and illness as she downed Romania's Monica Niculescu 6-2, 6-3 to win the Luxembourg Open title on Sunday.
Big-serving Canadian Milos Raonic made a strong return to competition on Friday by beating Viktor Troicki 6-3, 7-5 to reach the third round of the Miami Open.
The tournament will see the Williams sisters appearing together for the first time outside the Grand Slams.
Venus Williams, the world's former top-ranked tennis player, was the driver at fault in a two-car crash in Florida on June 9 that killed a passenger in the other vehicle, according to the initial police report on the incident released on Thursday.
Denmark's Caroline Wozniacki and the evergreen Venus Williams won their semi-finals at the Auckland Classic on Friday to set up a final showdown between two former World No 1s.
The former champion has withdrawn from the U.S. Open with a lingering stomach muscle injury.
Venus Williams made a triumphant return to the WTA Tour on Wednesday, winning her first round match at the Sony Ericsson Open in Miami.
Venus Williams showed that, almost a year after her health scare, she has the stamina needed as she battled for two hours 23 minutes to beat Russia's Maria Kirilenko 6-3, 6-7, 6-2 at the Cincinnati Open on Tuesday.
Seven-time Grand Slam champion Venus Williams has affirmed that she has no plans to bring down the curtains on her illustrious career and is targeting a place in the American team for the 2020 Tokyo Olympics.
The twice Wimbledon champion scored an easy victory over Katarina Srebotnik
Second seed Venus Williams tumbled out of the Family Circle Cup on Thursday, succumbing 6-4 7-6 to big-serving German Sabine Lisicki in the third round. The American, who had to battle the previous day before beating Indian Sania Mirza in three sets, lost the match in 87 minutes after the 16th-seeded German took the tiebreak 7-5.
Second seed Venus Williams needed three sets to beat battling Indian Sania Mirza 6-1 3-6 6-2 in the second round of the Family Circle Cup on Wednesday. After dominating the opening set, American Williams found herself in trouble in the second with the 100th-ranked Indian producing some great defence to save 10 out of 11 break points while breaking the American twice. Williams finally took control of the match in the third set.
Sania Mirza set up a second round clash with multiple Grand Slam winner and second seed Venus Williams after edging past Sesil Karatantcheva 6-4, 6-4 in the first round of the US $1 million WTA Family Circle Cup in Charleston.
The French top seed beat the American 4-6, 7-5, 6-4 in the final of the Antwerp Diamond Games.
Venus Williams gained revenge for her Wimbledon final defeat by Garbine Muguruza when the American advanced to the last four of the WTA Finals with a gutsy 7-5 6-4 victory over the Spanish world number two on Thursday.
Naomi Osaka's return a boost for women's tour, says Mouratoglou
Maria Sharapova defeated French qualifier Stephanie Foretz 6-1, 6-4 while Venus Williams survived British wildcard Naomi Cavaday.
Roger Federer was lucky to keep alive his dream of winning a maiden Roland Garros crown and Venus Williams used a good night's sleep to spare herself from a French Open nightmare in the second round on Thursday.
Ana Ivanovic claimed her first WTA Tour title in more than two years with a 6-2, 5-7, 6-4 victory over fellow former world number one Venus Williams to clinch the Auckland Classic on Saturday and boost her confidence ahead of the Australian Open.
Raonic advances, Sock ousted in Rogers Cup
Serena Williams remains on course for a record sixth win at the Sony Ericsson Open after beating sister Venus 6-4, 3-6, 6-3 to set up a final meeting with 19-year-old Belarusian Victoria Azarenka. Azarenka defeated Russian Svetlana Kuznetsova 6-3, 2-6, 7-5 in Thursday's other semi-final to book her place in a top tier final for the first time.
Venus Williams avoided another early exit with a routine win over fellow American Alison Riske at the Volvo Car Open in South Carolina while Swiss second seed Belinda Bencic was ousted by Russian qualifier Elena Vesnina.
IMAGES from Day 6 of the Wimbledon Championships, at the All England Lawn Tennis and Croquet Club, London, on Saturday.
IMAGES from the matches played at the Miami Open on Thursday
Tennis stars Venus Williams and Tomas Berdych have posed naked for ESPN The Magazine's Body Issue.
The three-time former champion entered her sixth Wimbledon final, beating Serbian teenager Ana Ivanovic.
The Williams sisters will in the United States' Fed Cup match against Belgium in April.
Images from the third day at the US Open, the final Grand Slam tournament of the year, in New York, on Wednesday:
Venus Williams beat Jill Craybas 6-3, 6-1 to book her spot in the Japan Open second round.
Top seed Venus Williams beat Flavia Pennetta while the Russian accounted for Eleni Daniilidou of Greece in Saturday's semi-finals.
Spain's Carla Suarez Navarro came back from a dreadful first set to defeat Venus Williams.
Venus Williams battled past fellow American Laura Granville 7-6, 6-4 to reach the Memphis International semi-finals