Riyad Mahrez struck twice as Manchester City reached the Champions League final for the first time thanks to a 2-0 victory over Paris St Germain at the Etihad Stadium on Tuesday that secured a 4-1 aggregate win.
Madrid's trip to San Sebastian was full of intrigue after Barca failed to beat Sevilla and the Catalan side's defender Gerard Pique said the title was now Madrid's for the taking.
The result leaves Ole Gunnar Solskjaer's United in 10th with nine points, their worst start after seven games for 30 years, and they have won just one of their last six league games.
Manchester City thrashed Southampton 6-1 to remain top of the Premier League.
Fans protested against Monday night football in the Bundesliga as Eintracht Frankfurt beat visiting RB Leipzig 2-1, delaying the start of both halves of the match, the second by throwing hundreds of tennis balls onto the pitch.
A first-half double from Karim Benzema helped Real Madrid cruise to a 3-0 victory away to Cadiz that moved them top of La Liga.
News of all that's transpired on and off the football field
Hellas Verona produced a huge upset by coming from behind to beat Serie A leaders Juventus 2-1 on Saturday, inflicting a third defeat of the season on the Italian champions. Cristiano Ronaldo set a new Juventus record by scoring in a 10th consecutive league game to put the visitors in front at the Stadio Marc'Antonio Bentegodi after 65 minutes.
Brighton and Hove Albion scored late to earn a 1-1 draw at Crystal Palace. Sheffield United and Fulham also drew 1-1 as both teams picked up their first points.
Ronaldo went off in the first half of the Euro 2020 qualifier with an apparent hamstring injury. The match ended 1-1.
IMAGES from soccer matches played across Europe on Sunday.
Marco Asensio's strike earned Real Madrid a 1-0 win over Espanyol to send them top of La Liga and Thomas Lemar scored his first goal for Atletico Madrid in a 2-0 victory at Getafe on Saturday.
Images from the English Premier League matches played on Saturday.
Images from the matches played across football leagues in Europe on Sunday.
Images from Saturday's action in the English Premier League.
Brighton & Hove Albion scored three times in the second half to fight back from two goals down and beat Manchester City
The 2-2 draw in Kaliningrad was thrilling for neutrals but exposed huge vulnerabilities in the 2010 world champions, who had to come from behind twice after careless mistakes gifted two goals to already-eliminated Morocco.
Arsenal's best chance to equalise came from a Granit Xhaka free kick which looked destined for the top corner until the Gunner's former keeper Emiliano Martinez at full stretch pushed it around the post with a fingertip save.
IMAGES from the English Premier League matches played on Saturday.
'If technology is not to be used for the fairness and transparency of the game and to ensure that it is equitable to all, then why use technology at all?'
Round-up of football matches played around Europe on Saturday.
Atletico Madrid fell to their heaviest league defeat of the season
Images from the English Premier League matches played on Saturday
Leicester City suffered a frustrating night on the south coast as they were held to a 1-1 draw in the Premier League
IMAGES from the English Premier League matches played on Wednesday.
Spain and Portugal played out an entertaining 0-0 draw on Friday as both sides prepared for this month's European Championship.
Soccer highlights from across the globe.
Images from the English Premier League matches played on Wednesday night.
Round-up of World Cup qualifiers played on Friday
