Ronaldo's replacement Dybala scored in the 77th minute with a goal the Portuguese would have been proud of. After a quick exchange of passes, the Argentine twisted past Alessio Romagnoli and beat Gianluigi Donnarumma with a right foot shot.
Atletico Madrid striker Antoine Griezmann struck twice as the Spanish side outclassed hapless Olympique de Marseille 3-0 on Wednesday to win the Europa League for the third time.
Diego Costa gave Europa League holders Atletico a dream start against Champions League winners Real by firing them ahead after 49 seconds, knocking down a long pass and smashing the ball into the net from a tight angle.
Photos from the UEFA Champions League last 16 first leg-matches played on Wednesday
Real Madrid and Atletico each slipped 10 points behind La Liga leaders Barcelona after an intense Madrid derby finished goalless and the Catalans picked up an 11th victory in 12 games by winning 3-0 at Leganes.
Barcelona coach Luis Enrique said he was shocked by the wild knee-high challenge on world player of the year Lionel Messi that triggered a straight red card for Atletico Madrid's Brazilian defender Filipe Luis on Saturday. The coach, whose side won 2-1 at home to go three points clear in La Liga, protested angrily on the touchline after the left back's studs-up tackle against the Argentine forward shortly before half time. "Did you see my reaction? Then you can imagine what I was thinking. It shocked me but I am not going to go into details about it," he told a news conference at the Nou Camp.
Barca coach, Luis Enrique says that all is well at Camp Nou and the team is united.
Defender Filipe Luis has rejoined Atletico Madrid from Chelsea in a reported 16 million euro ($17.66 million) deal, the Spanish club said.
Spain forward Fernando Torres has agreed to return to Atletico Madrid on loan from AC Milan until the end of the 2015-16 season.
Spanish teams have ruled with an iron fist in Europe for the last few years but a disappointing round of results in the Champions League has left the media wondering if this dominant era might be grinding to a halt.
IMAGES from the Europa League matches played on Thursday
A Marco Asensio-inspired Real Madrid crushed Eibar 3-0 to close the gap on La Liga leaders Barcelona to five points on Sunday, with Karim Benzema starting on the bench.
Real Madrid win UEFA Champions League
Chelsea's Spanish striker Diego Costa was named along with usual suspects Lionel Messi and Cristiano Ronaldo in the 23- man FIFA Ballon D'Or short-list released on Tuesday.
A summary of Wednesday's matches in the UEFA Champions League.
Emotions ran high as Nantes paid tribute to their former player Emiliano Sala on Wednesday in their first game since the Argentine went missing in a light aircraft over the English Channel.
The Portuguese forward then fired in the penalty in the sixth minute of stoppage time.
A round of Saturday's matches in Series A, La Liga and Bundesliga.
La Liga's reputation as the epicenter of world soccer talent has been bruised by the world record smashing sale of Neymar to Paris St Germain and how Barcelona react to the departure of one of their leading players will define the new season in Spain.
Goa Chief Minister Manohar Parrikar on Thursday accused a Nigerian diplomat of sending "offensive SMSes" to a senior police officer over the controversy relating to the killing of a Nigerian national that had sparked protests by his compatriots in Panaji.
India on Thursday said it was in "diplomatic dialogue" with Nigeria after that country raised the killing of one of its nationals in Goa last week and noted that it was expecting a report from the state government in the matter by Thursday.
Images from the Champions League round of 16 second leg matches played on Tuesday
First meets second as Barcelona host Atletico Madrid on Saturday looking to tighten their grip on the La Liga title race. The sides are level on 48 points at the top of the table, but Barca have a game in hand on Atletico and can take a huge step towards a fifth title in seven years with an eighth consecutive win in all competitions. Indeed, Luis Enrique's men remain on course for a repeat of the treble of La Liga, Champions League and Copa del Rey they won last season after progressing to the semi-finals of the Cup with a come from behind 3-1 win over Athletic Bilbao in midweek. Yet, the European champions have been far from their best in the past week as they were outplayed by Malaga and Bilbao in the first-half before being salvaged by individual moments of magic after the break. "We are aware of the errors we need to correct," said Luis Suarez after taking his tally for the season already to 30 with the equalizer against Bilbao.
Barcelona leapfrogged Atletico Madrid to go top of La Liga after Lionel Messi's acrobatic volley secured a hard-fought 2-1 victory against tenacious Malaga on Saturday.
Barcelona midfielder Sergio Busquets has become the latest to insist that all is well at the club, dismissing reports of a rift between Argentina forward Lionel Messi and coach Luis Enrique.
IMAGES from the La Liga matches played on Tuesday
When Barcelona host local rivals Espanyol on Saturday hoping to edge closer to the La Liga title, many may be haunted by Raul Tamudo's 89th minute equaliser which wrecked their title bid in 2006/07.
Atletico Madrid captain Gabi said his team would not be lulled into complacency by Barcelona's faltering form when they host the Champions League holders in the second leg of their quarter-final on Wednesday.
Last season's treble winners Barca are in their worst run of form in La Liga since coach Luis Enrique took charge in August 2014.
News of all that's transpired on and off the football field
News of all that transpired on and off the field.
Real Madrid's unbeaten start to the La Liga season came to an abrupt and surprising end as Real Mallorca claimed a stunning 1-0 victory at a rocking Son Moix on Saturday to climb out of the relegation zone.
News of all that's transpired on and off the football field.
Barcelona came through a testing local derby at Espanyol, winning 3-0 to cling to their slender lead at the top of La Liga after rivals Real Madrid had set the challenge by beating Valencia 2-1 in the earlier kick-off.
Alvaro Morata again proved decisive from the bench by striking a late winner against Athletic Bilbao and firing a lacklustre Real Madrid to the top of La Liga on Sunday. The Spain international has been afforded limited opportunities in his first season back at Real following two years with Juventus, struggling to usurp first choice forwards Gareth Bale, Cristiano Ronaldo and Karim Benzema. Morata has made just four league starts, but has scored four times in all competitions.
Atletico Madrid made a typically aggressive start to lay the foundations for a 2-0 victory at home.
News of all that's transpired on and off the football field
Atletico Madrid have a chance to pile more King's Cup misery on neighbours Real after eliminating Athletic Bilbao on Wednesday to set up a last-four clash against the bitter city rivals they beat in last year's final.
Champions Barcelona begin their bid for a sixth La Liga title in eight years at Athletic Bilbao on Sunday knowing that fellow heavyweights Real Madrid could, unusually, be just one of several challengers for their crown.
Lionel Messi scored twice as La Liga champions Barcelona saw off a persistent Valencia side, who had Eliaquim Mangala sent off in the first half, to win 4-2 on Sunday and stay on the heels of leaders Real Madrid.
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