European heavyweights Barcelona, Bayern Munich, Juventus and Paris St Germain all maintained their leads and Benfica toppled Sporting Lisbon.
Barcelona coach Luis Enrique is expecting an even greater impact from Luis Suarez this season with the cloud of disciplinary problems no longer hanging over the Uruguay striker.
Barcelona have completed their business in the latest transfer window and the Spanish and European champions' squad is now "closed", president Josep Bartomeu said on Thursday.
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Evergreen Francesco Totti, in his 22nd season with AS Roma, scored his first goal of the new campaign to give help them to a 3-1 win at Parma which maintained their 100 percent record in Serie A.
World Cup hosts Russia got their Nations League campaign off to a flying start with a 2-1 win away to Turkey thanks to goals from Dennis Cheryshev and Artem Dzyuba on Friday.
Barcelona have been drawn to play Pep Guardiola's Bayern Munich in the Champions League semi-finals. The other last-four tie will see Juventus, in their first semi-final since 2003, take on Carlo Ancelotti's Real Madrid, the defending champions.
Goals from Jan Vertonghen and Jermain Defoe left Tottenham Hotspur on the cusp of the Europa League knockout stages as four other clubs maintained perfect starts on Thursday.
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AS Roma coach Rudi Garcia succeeded where his three predecessors failed by taking his team to a 2-0 win over arch-rivals Lazio on Sunday and maintaining their 100 percent record in Serie A alongside Napoli who won 2-1 at AC Milan.
Milan replaced Gennaro Gattuso with former Sampdoria coach Giampaolo during the close season in a bid to improve on last season's fifth place and to take them back to the Champions League.
The Portuguese forward then fired in the penalty in the sixth minute of stoppage time.
A round of Saturday's matches in Series A, La Liga and Bundesliga.
Juventus moved nine points clear at the top of Serie A after defeating Palermo 4-0 at home on Sunday and Francesco Totti bagged a dramatic late equaliser as AS Roma drew 3-3 at Atalanta.
Juventus goalkeeper Gianluigi Buffon saved a penalty and Andrea Pirlo curled in a trademark free kick late in the game to give the Serie A leaders a dramatic 1-0 win at Genoa on Sunday.
Gonzalo Higuain scored his 30th league goal of the season but was later sent off and had to be restrained by his team mates as Napoli lost 3-1 at Udinese on Sunday, severely denting their Serie A title hopes.
Napoli's Manolo Gabbiadini netted a precious second-half equaliser to earn a 1-1 away draw at Lazio in the first leg of their Italian Cup semi-final on Wednesday.
La Liga leaders Barcelona handed Real Madrid more hope in the title race as they drew 0-0 at Athletic Bilbao on Sunday, only avoiding defeat thanks to some outstanding saves by Marc-Andre ter Stegen.
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'The problem with Petr is that an opponent is better than before'
Barcelona coach Luis Enrique was pleased they got straight back into their stride with Tuesday's 2-1 friendly win over the Los Angeles Galaxy.
Claudio Ranieri re-named himself The Thinkerman on Thursday as he reflected on masterminding Leicester City's improbable rise from relegation candidates to Premier League champions.
Check out the top footballers of the weekend.
AC Milan's winning streak ended as they were held 0-0 at home by Atalanta in Serie A on Saturday while Bologna beat struggling Hellas Verona 2-0 away to move out of the relegation zone.
Ten-man Inter Milan replaced AS Roma atop Serie A, at least for 24 hours, after beating Bologna 1-0 away on Tuesday to end a run of four games without a win but coach Roberto Mancini, who was sent off at the end, wants more from his side.
The injury to the Chile forward, who was left out of the squad for Tuesday's Champions League victory over Young Boys, "will require further investigation to confirm its severity", the club added.
Defiant Brazil manager Dunga brushed off suggestions that early elimination from the Copa America would cost him his job on Sunday, telling reporters that he feared 'only death' and not unemployment.
News of all that's transpired on and off the football fie
News of all that's transpired on and off the football field
A spectacular piledriver from Juan Cuadrado gave Serie A leaders Juventus a 1-0 win over Inter Milan, ending a run of seven successive Serie A wins for their opponents in a pulsating end-to-end match on Sunday.
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Andrea Pirlo and Miralem Pjanic provided the moments of magic to inspire leading Serie A duo Juventus and AS Roma to battling victories on Sunday with the gap between the sides remaining at three points.
Valverde said he was concerned about the team's away form after they were comprehensively beaten 2-0 by promoted Granada
Qatar, host nation of the 2022 World Cup, is still doing little to improve conditions for migrant workers despite promising reform last year, Amnesty International said on Wednesday.
The victory moved second-placed Bayern, who take on Celtic in the Champions League next week, up to 17 points, two behind Dortmund who suffered their first home loss in 41 league matches.
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
Back in Italy after a four-year absence, Felipe Melo has quickly made his mark on Serie A and told those who do not like his combative style to 'go and play tennis'.
AC Milan's troubles continued when they conceded an equaliser in the fifth minute of stoppage time and were held 2-2 by modest visitors Verona in Serie A on Saturday.
Check out the top footballers of the weekend...