Manchester United humbled Manchester City 4-2 in the continent's big derby of the weekend.
Leicester rely on the old fashioned virtues of work rate, no-nonsense defending and speedy attacks.
A summary of Saturday's action in Ligue 1, La Liga and Serie A.
Lionel Messi dragged Barcelona back from two goals down by scoring twice to snatch a 2-2 draw at home to Valencia in a thrilling encounter.
News of all that's transpired on and off the football field
Cristiano Ronaldo finally became the highest scorer in Real Madrid's history while Bayern Munich set a record for the greatest number of successive wins at the start of a season in the Bundesliga this weekend.
Lionel Messi came off the bench to preserve Barcelona's unbeaten run in La Liga with a sensational late equaliser in a thrilling 2-2 draw at Sevilla on Saturday as the runaway leaders came back from two goals down in the space of a minute.
News of all that's transpired on and off the football field
Ten of the 16 sides also reached the same round two seasons ago and, as usual, the big five leagues dominate with 13 clubs hailing from either the English, Spanish, German, French and Italian leagues.
European heavyweights Barcelona, Bayern Munich, Juventus and Paris St Germain all maintained their leads and Benfica toppled Sporting Lisbon.
News of all that's transpired on and off the football field
New coach Luciano Spalletti failed to inspire AS Roma as they were held 1-1 at home by bottom club Verona on his debut on Sunday and Juventus notched their 10th Serie A win in a row by hammering Udinese 4-0 away.
Real Madrid lifted the FIFA Club World Cup for a record fourth time on Saturday after thrashing local side Al Ain 4-1 in the final in Abu Dhabi with the help of impressive distance strikes in either half from midfielders Luka Modric and Marcos Llorente.
A weekend of surprise results across Europe's big leagues saw Bayern Munich's unbeaten run come to an end, Napoli knocked off top spot in Serie A and Manchester City toppled in the Premier League where Leicester City are the new leaders.
All the latest football news from around Europe.
Here's a glimpse at what happened around the world last week.
News of all that's transpired on and off the football field
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