Liverpool have the joint biggest lead in top-flight history at this stage of the campaign and no team has ever failed to win the title with an advantage of this size. Already there is talk of Liverpool going through the league entire season unbeaten -- matching the 'The Invincibles' of Arsenal in 2003/04 and Preston North End in 1888/89.
United's leading goal-scorer suffered knee ligament damage during the 2-1 Europa League quarter-final win over Anderlecht last month and has been ruled out for the rest of the season.
Liverpool's Brazil midfielder Philippe Coutinho is on the verge of signing for La Liga leaders Barcelona in a club-record deal, according to Spanish media reports.
News of all that's transpired on and off the football field
With United unable to sign a replacement, the pressure will be on 21-year-old England forward Marcus Rashford to deliver the goals in a more central role than he has previously operated in.
Liverpool manager Juergen Klopp called for his players to "stay calm" and does not expect to expect wholesale changes against Burton Albion on Tuesday as they seek to quickly bounce back from their 2-0 defeat at Burnley.
The experienced members of England's World Cup squad must step up
Following is a match by match look at the English Premier League's weekend fixtures.
Brazil international Sandro was picked out for special praise by manager Harry Redknapp after Queens Park Rangers leapfrogged Burnley at the foot of the Premier League table on Monday.
Images from the FA Cup matches played on Saturday
FA Cup: Arsenal end Lincoln's adventure
Manchester City claimed the win required to finally end Liverpool's relentless attempt to dethrone them as Premier League champions as they hit back from a goal down to crush Brighton and Hove Albion on the south coast on Sunday.
A preview of the line-up action in the English Premier League.
Premier League leaders Chelsea are focused on getting results in their remaining nine games as they fight for the title, instead of dwelling on Saturday's 2-1 loss to Crystal Palace, manager Antonio Conte said.
Louis van Gaal came under fresh attack on Friday over his style of play at Manchester United and acknowledged he was still struggling to come up with a preferred system.
Liverpool's Daniel Sturridge has urged manager Juergen Klopp to deploy him in his favoured centre forward position, where he operates on "autopilot".
News of all that's transpired on and off the football field
Bolton Wanderers have sacked manager Owen Coyle after the club suffered a poor start to their Championship (second division) campaign following their relegation from the Premier League at the end of last season.
Despite Manchester City officials trying their best to sign Lionel Messi in recent years, manager Pep Guardiola has in contrast expressed his deep desire to see Argentine star striker end his illustrious career at Barcelona. Guardiola, who had worked with Messi for over four years in Barcelona, believes that the Camp Nou club has become the striker's home. "Messi will finish his career at Barcelona that is what I desire deeply. I want him to be there from the beginning to the end," Marca quoted Guardiola as saying.
News of all that transpired on and off the football field.
Both Manchester clubs remain unbeaten in the league with City atop the standings on 22 points and United two points behind after eight league games, followed by Tottenham Hotspur and Watford in third and fourth respectively.
Arsenal manager Arsene Wenger brushed off suggestions that his four-match touchline ban for pushing a fourth official was too lenient, saying his critics would still not be satisfied if he was put behind bars.
Images from Europa and Champions League matches played on Wednesday.
Arsenal visit Liverpool looking for a first league win at Anfield since 2003. Defeat for Arsene Wenger's side will move seventh-placed Liverpool within a point of them, having played a game more.
Images from the English Premier League matches played on Tuesday
Manchester City manager Pep Guardiola hailed his team
Images from EPL matches played on Wednesday
'Solskjaer has improved morale by freeing players from the shackles with which Mourinho had bound them.' 'He has made his team a happier bunch of people,' says Suhit K Sen.
City's dream of a quadruple of titles ended with their away-goals loss after Wednesday's second-leg ended with a 4-3 win, but a 4-4 aggregate score.
ManchesterCity manager Pep Guardiola has expressed doubts over whether Manchester United can challenge for the Premier League title but believes they have a realistic chance of finishing in the top four.
Upcoming matches in the English Premier League.
Following is a match by match look at the English Premier League's weekend fixtures:
Everton yet to receive clarification after City game postponed: Ancelotti
The schedule of matches in the English Premier League between Saturday, September 26 and Monday, September 28.
Brighton & Hove Albion scored three times in the second half to fight back from two goals down and beat Manchester City
Harry Kane toppled Alan Shearer's 22-year-old record for the most Premier League goals in a calendar year by scoring a double for Tottenham Hotspur against Southampton, on Tuesday, also overtaking Lionel Messi as the top scorer in Europe.
Following is a match by match look at the English Premier League's weekend fixtures:
Chelsea will begin 2015 protecting a three-point lead in the Premier League title race but will heed the words of their grand old striker Didier Drogba who warns that it is simply not enough.
Mario Balotelli will return to Liverpool's squad for the festive programme but manager Brendan Rodgers was hardly effusive in his praise of the Italy's striker's credentials.
Manchester United have surpassed local rivals Manchester City in the Premier League table in terms of salary paid to their players.
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