Guardiola gave a debut to close-season signing Nathan Ake, the Dutch defender signed from Bournemouth, lining up alongside John Stones in the centre of defence.
Tottenham Hotspur have the chance to exert psychological pressure on Premier League leaders Chelsea when they open the weekend programme at home to Watford on Saturday.
Manchester City host Tottenham Hotspur on Saturday on the back of a record 15 successive English Premier League wins, and on the basis of their visitors' recent away form, a 16th victory appears to be the likely outcome.
A preview of the line-up action in the English Premier League from October 20-22.
'If you look at the points we've lost at home -- all the matches where we draw -- you're thinking about 10 or 12 and, with these points we wouldn't just be speaking about the top four, we'd be speaking about the top two or the top one'
Mohamed Salah was inevitably on the scoresheet as Liverpool took full advantage of the inactivity of their top-four rivals to thrash West Ham United 4-1 at Anfield and provisionally move into second in the Premier League.
A round-up of Saturday's matches in the English Premier League.
Manchester United battled back from two goals down to beat Newcastle United 3-2 at Old Trafford on Saturday as a 90th-minute winner from Alexis Sanchez completed a spirited comeback to ease the pressure on manager Jose Mourinho.
Images from the EPL matches played on Saturday
UEFA had banned City from European competition for two years after ruling they had breached Financial Fair Play (FFP) regulations but City won an appeal last month to have that verdict and sanction overturned.
Chelsea brought a whole new dimension to the Premier League title race when they handed Manchester City their first defeat of the season on Saturday to leave Mohamed Salah-inspired Liverpool as the new leaders.
Hull City boss Steve Bruce has been interviewed by a three-man Football Association (FA) panel for the England manager's job, according to British media reports.
Liverpool went into last Sunday's Merseyside derby on the back of five wins from their previous six league games but were held to a 1-1 draw at Anfield by Everton and then to a goalless stalemate at home against West Bromwich Albion on Wednesday.
News of all that's transpired on and off the football field
Manchester United manager Jose Mourinho was sent off for the second time in a month on Sunday as the controversial coach watched his side draw 1-1 at home to West Ham United and lose more ground in the English Premier League title race.
Kevin de Bruyne was hailed as playing football "on another level" by his manager Pep Guardiola after the Belgian maestro orchestrated another Manchester City symphony on Saturday.
Manchester United manager Louis van Gaal blamed injuries and unrealistic expectations for his team's disappointing season after a 3-1 win over Bournemouth on Tuesday confirmed a fifth place finish in the Premier League.
A suspicious package destroyed by a bomb disposal team after prompting the evacuation of Manchester United's stadium on Sunday was a fake device accidentally left behind after a training exercise, police said.
Irresistible Chelsea go into the Christmas round of fixtures knowing they can end the year by re-writing the record books.
Manager Guus Hiddink dismissed speculation that Eden Hazard will leave English Premier League champions Chelsea, insisting that the winger is content to stay at Stamford Bridge.
Swansea City's hopes of salvaging their place in the Premier League suffered a potentially grievous blow as Ryan Fraser's deflected strike earned Bournemouth a 1-0 win on Saturday to secure another season of top-flight football for the Cherries.
Rooney, the all-time leading goalscorer for club and country, has started eight Premier League games this season and has not played since Feb. 1.
News of all that's transpired on and off the football fieLd
Champions Chelsea begin title defence at home to Swansea City, while runners-up Manchester City kick-off at West Bromwich Albion
News of all that's transpired on and off the football field
Chelsea manager Maurizio Sarri said Eden Hazard is free to leave the club if he wants to but the Italian hopes the forward stays at Stamford Bridge.
Here are five talking points from the weekend's action:
Newcastle United finally put manager Steve McClaren out of his misery when they sacked him on Friday after a period of intense speculation surrounding his future.
Arsenal midfielder Aaron Ramsey hopes the North London can choke LeicesterCity's unexpected Premier League title charge after picking up their first win in five matches in Sunday's 2-0 win over Bournemouth.
Striker Costa ends second spell at Atletico Madrid.
Manchester City beat bottom club Sheffield United 1-0 to move three points clear of Manchester United who were held to a goalless draw at Arsenal in the Premier League on Saturday.
Champions Manchester City will expect to get back to winning ways at home to Newcastle United in a match which pits Pep Guardiola against his fellow Spaniard Rafa Benitez.
News of all that's transpired on and off the football field.
Manchester City overcame a spirited Bournemouth side 3-1 on Saturday to maintain their unbeaten streak and extend their lead at the top of the English Premier League to five points.
Liverpool manager Juergen Klopp is expecting his toughest test yet in a Merseyside derby when his side face local rivals Everton in the Premier League on Sunday.
Aston Villa beat Crystal Palace 1-0 to win a Premier League match for the first time since August while a late goal from Paul Dummett earned a 3-3 draw for Newcastle United against Manchester United on Tuesday.
Manchester United climbed back up to second in the table after second-half goals by Anthony Martial and Jesse Lingard earned a 2-0 victory at Everton -- their first win in five games in all competitions.
Among other transfer news globally, defender Rahul Bheke joins Mumbai City FC while Locatelli completes Juventus move.
The Egyptian reached the 40-goal mark across all competitions this season in Liverpool's 3-0 Premier League win over Bournemouth on Saturday and is leading the race for the European Golden Shoe after an impressive campaign.
Chelsea staged a spectacular comeback with three goals in nine second-half minutes to beat Southampton 3-2 on Saturday and revive their faint hopes of a top-four Premier League finish as Saints remained in the drop zone.
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