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Stoke thought they had secured all three points and their first away win since October when substitute Peter Crouch knocked a loose ball into the back of the net after West Ham's England goalkeeper Joe Hart spilled a shot after 79 minutes.
Andy Carroll scored a eight-minute hat-trick as West Ham United's last London derby at Upton Park ended in a barnstorming 3-3 draw with Arsenal on Saturday -- a result that dented both club's respective ambitions.
Leicester City stumbled on their march towards the Premier League title when they drew 2-2 with West Ham United and had goalscorer Jamie Vardy sent off at the King Power Stadium on Sunday.
Arsenal, who fired Unai Emery as manager last week and appointed former player Freddie Ljungberg as caretaker boss, now sit 10th in the table on 19 points, with Brighton a single point behind and three places below them.
With United unable to sign a replacement, the pressure will be on 21-year-old England forward Marcus Rashford to deliver the goals in a more central role than he has previously operated in.
Images from Sunday's action in the Premier League.
Alexis Sanchez grabbed a 15-minute hat-trick as Arsenal shook off any hangover from their midweek League Cup defeat to thrash West Ham United 5-1 and climb to second in the English Premier League.
Chelsea brushed aside London rivals West Ham United with a 2-1 away win that restored their 10-point lead at the top of the Premier League on Monday.
Arsenal's victory was scrappy and nervy but Laurent Koscielny's 72nd-minute winner was enough to move them two points clear at the summit after LeicesterCity's surprise push faltered with a goalless draw at home to 10-man Bournemouth.
IMAGES from the English Premier League matches played on Saturday.
Northern Ireland set a record of 10 games unbeaten with a 1-0 win over Slovenia after a goal by Conor Washington in a friendly on Monday in the build-up to their first European Championship.
Images from the English Premier League matches played on Wednesday.
Arsenal ended their away hoodoo against Premier League title challengers with a 2-0 victory at Manchester City on Sunday that left Chelsea five points clear at the top.
Under-pressure Everton manager Roberto Martinez enjoyed some respite as his struggling side won for the first time in eight league matches.
Philippe Coutinho inspired Liverpool to a comfortable 3-1 home win over Everton in the 228th Merseyside derby on Saturday to move provisionally up to third in the Premier League.