Novak Djokovic said he does not know if will play the grasscourt season after tumbling out of the French Open on Tuesday.
Alexander Zverev fough back to enter his third consecutive French Open semifinals on Wednesday.
It will be the second time Nadal and Del Potro meet at Roland Garros. The previous match up saw the Spaniard beat Del Potro in straight sets in the opening round in 2007.
Australian Nick Kyrgios did his best to enliven a damp and dismal Parisian day with some eye-catching play and colourful language as the French Open began without part of the usual furniture on Sunday.
World No. 16 Marco Cecchinato will spearhead Italy's challenge, while they also have the experienced world No. 37 Andreas Seppi as they look to continue their good record against India.
Italian tennis player Marco Cecchinato has been banned for 18 months and fined 40,000 euros ($44,024) for match-fixing, the Italian tennis federation has announced.
'If I win the Australian Open, I will be the happiest person on the planet. I think that the (money) will be in much better use in the hands that know what to do with it, and know how to help others.'
Cecchinato in 'dreamland' after stunning David Goffin on Sunday
No Italian man has won a Grand Slam since Adriano Panatta triumphed at Roland Garros in 1976 and if there is any chance that Sinner, Musetti or Berrettini will lift the Musketeers Cup this year, they will face their biggest obstacles in the next round when they take on the might of Nadal, Djokovic and Federer respectively.
IMAGES from the French Open semi-finals played at Roland Garros on Friday
Organisers are confident a rain-hit opening day will not hold up the tournament.
IMAGES from matches on Day 10 at the French Open at Roland Garros
India's number one player Prajnesh Gunneswaran, who achieved career-high 102 ranking this week, has been drawn against 22-year-old debutant Matteo Berrettini in the second singles rubber at the Calcutta South Club grass courts.
Novak Djokovic suffered his first defeat of the new season in the Qatar Open semi-finals on Friday, losing in three sets to Spain's Roberto Bautista Agut.
Andreas Seppi experienced some early hiccups before getting past Ramkumar Ramanathan 6-4, 6-2 in the opening rubber, while 22-year-old Matteo Berrettini made a winning Davis Cup debut, cruising past India number one Prajnesh Gunneswaran 6-4, 6-3.
Novak Djokovic boosted his chances of playing at Wimbledon after he accepted a wildcard to compete at next week's Fever-Tree Championships at Queen's Club, tournament organisers said on Monday.
Captain Mahesh Bhupathi, on Wednesday, made it clear that India won't miss veteran Leander Paes during their upcoming Davis Cup Qualifier against fancied Italy at Calcutta South Club on Friday-Saturday.
World number two and top seed Caroline Wozniacki, runner-up at the south coast event last year, cruised into the semi-finals with a 6-4, 6-3 win over Australia's Ashleigh Barty.
Raonic advances, Sock ousted in Rogers Cup
Former Wimbledon runner-up Eugenie Bouchard successfully negotiated the qualifying draw on Thursday, beating Colombian Mariana Duque-Marino 6-3, 6-2 to secure a spot in next week's main draw.
Win is the only thing on Seppi's mind and he is focussed on giving his country the lead on Friday.
World number one Novak Djokovic turned the page on his contentious US Open exit and began his claycourt season with a convincing 6-3, 6-2 victory over wildcard Salvatore Caruso in the second round of the Italian Open.
The 32-year-old, who has not played since retiring injured in the US Open semi-finals, cited an abdominal injury.
Yuki Bhambri breezed past Italy's Marco Cecchinato in the opening round of the qualifiers in the Chennai Open on Saturday.
Twice Shanghai Masters champion Roger Federer was far from his best against Spain's Roberto Bautista Agut but did enough to reach the quarter-finals with a 6-3, 2-6, 6-4 win on Thursday.
IMAGES from matches on Day 8 at the French Open
Juan Martin del Potro could be a 'nightmare opponent' for Rafael Nadal when they clash in the French Open semi-finals on Friday, according to former champion Mats Wilander.
Summary of sports events and persons who made news on Wednesday
With rain having washed out Wednesday's play, Federer along with champion Rafael Nadal and top seed Novak Djokovic all face playing back-to-back matches on Thursday if they want to reach the quarter-finals.
"This is going to be a huge confidence boost and springboard for whatever is coming up and for the rest of my career."
Keeping in mind Italians' weakness on grass, India have opted for grass courts in South Club here for the February 1-2 fixtures which will be played in new format with the winners making a cut to the 18-nation finals in Madrid next year.
IMAGES from matches played on Day 4 of the French Open at Roland Garros on Wednesday
Images from Day 3 of the French Open matches played at Roland Garros on Tuesday
Keeping the 2020 Tokyo Olympics in mind, the sports ministry has included the doubles duo of Rohan Bopanna and Divij Sharan, who won the Asian Games gold last year, have been kept in TOPS scheme.
Defending champion Simona Halep was knocked out of the French Open 6-2, 6-4 by 17-year-old American Amanda Anisimova in a quarter-final shock.
A 1,000km 10-hour roadtrip dash to Paris, squeezed into a small hire car alongside his 88-year-old grandmother, ended in Grand Slam joy for Marco Trungelliti at Roland Garros on Monday -- and a guaranteed 79,000 euros ($92,000) payday.
World No 15 India will now compete in the Zone Group action later this year.
Belgium's Elise Mertens rallied from a set down to beat top seed Simona Halep 3-6, 6-4, 6-3 and clinch her first Premier-level title at the Qatar Open on Saturday.
Images from Day 7 of the 2021 French Open at Roland Garros in Paris on Saturday.
Venus Williams staged a spirited comeback to down third seed Petra Kvitova 4-6, 7-5, 6-4 and reach the third round of the BNP Paribas Open in Indian Wells on Saturday.
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