Barcelona thrashed Real Betis 5-1 on Wednesday to book their spot in the Copa del Rey quarter-finals.
Real and Barca have won the title in 15 of the last 16 seasons, with Atletico breaking the duopoly in 2014.
Villarreal's slide continued as a Diego Castro header gave Getafe a 1-1 draw in La Liga on Sunday but the match was overshadowed by a serious injury to Mateo Musacchio.
Barcelona came from an early goal down to beat Real Madrid 5-2 in the Spanish Super Cup final on Sunday
A new-look Atletico Madrid suffered a setback in their opening La Liga match of the season when they squandered several chances and twice struck the post in a 0-0 home draw with Osasuna on Sunday.
Real Madrid barged their way back into the Spanish La Liga title race with a 3-1 victory over Atletico Madrid in a feisty derby at the Wanda Metropolitano on Saturday.
Barcelona suffered a shock 1-0 LaLiga defeat at Real Sociedad on Sunday that ended their seven-match winning streak in all competitions.
Lionel Messi hit a hat-trick as Barcelona warmed up for the El Clasico with Real Madrid next weekend with a 7-0 victory over Osasuna that put them four points off the top of La Liga.
Real Madrid's early-season woes deepened when they lost 2-1 at home to La Liga champions Atletico Madrid, while substitute Neymar struck twice in Barcelona's 2-0 win against visiting Athletic Bilbao on Saturday.
Real Madrid forward Cristiano Ronaldo faces a race against time to be fit for the Champions League semi-final second leg with Manchester City on May 4.
Real Madrid's Gareth Bale came off the bench and coolly converted a controversial penalty to secure a 2-1 win at Levante in La Liga on Sunday as the European champions rode their luck to stay within nine points of leaders Barcelona.
Marco Asensio's strike earned Real Madrid a 1-0 win over Espanyol to send them top of La Liga and Thomas Lemar scored his first goal for Atletico Madrid in a 2-0 victory at Getafe on Saturday.
Atletico Madrid moved a step closer to an unlikely Spanish title triumph when they battled back from a goal down to secure a 2-1 win at fourth-placed Athletic Bilbao in La Liga on Saturday.
Lionel Messi marked his 300th La Liga appearance with a record-equalling hat-trick and an assist for Neymar as Barcelona stayed hard on the heels of leaders Real Madrid with a 5-0 romp at home to Levante on Sunday.
Lionel Messi netted the 400th goal of his storied career on Saturday as Barcelona trounced Granada 6-0 to maintain the pace at the top of La Liga.
Giuseppe Rossi kept Europa League semi-finalists Villarreal on course for a place in the Champions League next season with a penalty to secure a 1-0 win over relegation-threatened Real Zaragoza in La Liga on Monday.
Cristiano Ronaldo and Lionel Messi scored twice as Ronaldo's Real Madrid came from behind to beat promoted Hercules 3-1 and Messi's Barcelona humbled 10-man Sevilla 5-0 in La Liga on Saturday.
Real Madrid stayed hard on the heels of leaders Barcelona when in-form striker Karim Benzema scored to set them on their way to a 2-1 win at battling city rivals Atletico in La Liga on Saturday.
Lionel Messi netted a superb double as Barcelona recovered from a shaky start to secure a 4-1 comeback win at rain-lashed Sevilla on Sunday that lifted the champions back to the top of La Liga.
Lionel Messi's late penalty saw bedraggled Barcelona scrape a 2-1 victory over Leganes on Sunday at a divided Nou Camp as the La Liga champions looked as if they had still not recovered from their harrowing midweek defeat to Paris St Germain.
Promoted Alaves dealt champions Barcelona a shock 2-1 defeat at the Nou Camp on Saturday while Cristiano Ronaldo returned from injury to help Real Madrid thrash Osasuna 5-2 and go two points clear at the top of La Liga. With Lionel Messi, Luis Suarez and Andres Iniesta on the bench, Barcelona went behind to the visitors in the 39th minute before Frenchman Jeremy Mathieu equalised in the 46th. Ibai Gomez then scored the winner in the 64th.
Barcelona equalled a club record of 12 consecutive league wins as Neymar and Lionel Messi were among the scorers in a 6-0 thrashing of struggling Getafe 6-0 at the Nou Camp on Saturday.
Karim Benzema went some way to justifying the 35 million euros ($49 million) Real Madrid paid to sign him when his goal secured a scrappy 1-0 home win over Real Mallorca in La Liga on Sunday.
Cristiano Ronaldo scored twice as Real Madrid beat Athletic Bilbao 4-2 in a thrilling match at the Bernabeu to move within a point of leaders Barcelona in La Liga on Saturday.
A late goal by Toni Kroos sealed victory as Real Madrid defeated an impressive Celta Vigo side 2-1 to win their first home La Liga game of the campaign on Saturday.
Atletico Madrid's Jackson Martinez scored his first goal for the club when he came off the bench and curled in a superb effort to seal a hard-fought 3-0 victory at Sevilla in La Liga on Sunday.
Gonzalo Higuain bagged a remarkable third hat-trick in two weeks to steer Real Madrid to a 4-1 win over Real Betis on Saturday while Lionel Messi's double kept Barcelona top of La Liga with a 3-0 victory over Racing Santander.
A fan who racially abused Real Madrid forward Vinicius Jr and Villarreal player Samuel Chukwueze in two games at Mallorca last year has been found guilty and handed a suspended prison sentence.
Messi, who has struggled for form in recent weeks due to a niggling injury, looked on a mission to grab the winner and after twice coming close he completed his treble to put Barca ahead in the 85th minute, reacting quickly to a poor Sevilla clearance to dink the ball over goalkeeper Tomas Vaclik.
Barcelona thrashed Sporting Gijon 6-1 to go top of La Liga on a dramatic night in Spain on Wednesday as Luis Enrique announced he was stepping down as the Catalan club's coach at the end of the season.
Lionel Messi made brilliance look routine with a stunning double to help Barcelona to a 5-0 win over Real Sociedad that restored the champions' two-point lead over Real Madrid at the top of La Liga on Sunday.
Barcelona leapfrogged Atletico Madrid to go top of La Liga after Lionel Messi's acrobatic volley secured a hard-fought 2-1 victory against tenacious Malaga on Saturday.
Cristiano Ronaldo ensured Atletico Madrid fans will have bitter memories of the last local derby at the Vicente Calderon stadium by scoring a hat-trick in a 3-0 win for La Liga leaders Real Madrid on Saturday. Ronaldo's deflected free kick put Real in charge in the 23rd minute in the first meeting of the teams since the Champions League final in May. The prolific Portuguese killed off Atletico's resistance by winning and converting a penalty in the 71st minute and capped a harrowing night for the home side by tapping in the third in the 77th.
An ineffectual Barcelona crashed to their first La Liga defeat of the season and failed to restore their three-point lead over Atletico Madrid at the top when they were beaten 1-0 at Athletic Bilbao on Sunday.
Schick on target again as Leverkusen win, Leipzig thrashed 5-1
Atletico Madrid have been unable to repeat the magnificent achievements of last season in this campaign but can congratulate themselves on a job well done if they secure a lucrative Champions League berth on Saturday.
Barcelona joined Real Madrid, Atletico and Real Sociedad in the semi-finals, with the draw set to take place on Wednesday.
Barcelona took another step towards retaining their La Liga title when goals from Bojan Krkic, Pedro and Yaya Toure fired them to a 3-0 home win over Deportivo Coruna on Wednesday.
Atletico midfielder Saul Niguez, however, criticised his side for not showing enough ambition early in the game.
Real Madrid climbed back above Barcelona to the top of La Liga when Cristiano Ronaldo and Gonzalo Higuain both netted twice to seal a convincing 4-2 victory at city rivals Getafe on Thursday.
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