Real also have an outstanding defence, conceding only 25 times last year, and are well covered in every position.
A round-up of Tuesday's action in the UEFA Champions League.
Ronaldo, who won the award last year, topped the scoring charts with 15 goals in the competition as Real Madrid won a third consecutive European crown.
Germany have four players and Argentina three in the 10-man FIFA shortlist for the adidas Golden Ball, which is awarded to the World Cup's most outstanding performer.
A round-up of Wednesday's action in the UEFA Champions League.
Images from the UEFA Champions League matches played on Wednesday night.
Star footballers Lionel Messi, Manuel Neuer and Cristiano Ronaldo, who had been shortlisted for the FIFA Ballon d'Or award, have been selected by their peers for the 2014 FIFPro World XI team.
Real and Barca have won the title in 15 of the last 16 seasons, with Atletico breaking the duopoly in 2014.
Bayern Munich and Atletico Madrid made it four away wins from the opening four Champions League last-16 first leg matches when they triumphed at Arsenal and AC Milan respectively on Wednesday.
Luis Suarez had been told by new Barca coach Ronald Koeman that he was not in his plans for next season.
Thirteen-times European champions Real, who had come through each of their last three Champions League semi-final ties, had been second best for much last week's first leg which ended 1-1.
Arsenal and Manchester City face monumental tasks when they visit European powerhouses Bayern Munich and Barcelona looking to overturn 2-0 deficits in the second legs of their Champions League last-16 ties.
Images from the Champions League Round of 16, first round matches played across Europe on Wednesday.
Cristiano Ronaldo and Lionel Messi will resume their perennial battle to be crowned the world's best footballer after they headed the shortlist of 30 players for the 2016 Ballon d'Or announced on Monday.
Real Madrid defender Nacho was the unlikely hero as they snatched a 1-0 win at Real Valladolid on Sunday to capitalise on Barcelona's defeat at Valencia this weekend and move three points clear of their rivals at the top of La Liga. Serie A leaders Juventus suffered a shock 2-1 defeat at Napoli on Sunday, with coach Maurizio Sarri returning to his former club for the first time, though Cristiano Ronaldo still managed to score for an eighth league game in a row for the visitors.
Federico Valverde has already made over 100 appearances at senior level - while winning silverware and recognition both with his current side Madrid and country Uruguay, and showing the physical, technical and mental attributes to become one of world football's outstanding midfielders.
Belarussian side BATE Borisov caused one of the biggest shocks ever seen in the Champions League when they stunned last season's beaten finalists Bayern Munich 3-1 on Tuesday.
Zinedine Zidane's Real side demonstrated their new-found grit to re-take the lead
Bayern Munich left more than 50 million eurosworth of new signings on the bench, yet still managed to destroy shoddy VfB Stuttgart 6-1 in an embarrassingly one-sided Bundesliga contest on Sunday.
Barcelona were hailed as La Liga champions-elect in the Catalan media after their 1-0 win at Real Madrid on Saturday, while the capital's press called for sweeping changes at Real after another domestic failure.
'A minor setback is not a bad thing to bring the team closer together'
Sunday's World Cup defeat by Mexico should not really be seen as a surprise, defender Mats Hummels
Key head-to-head battles in Saturday's "Clasico" between Real Madrid and Barcelona at the Bernabeu stadium (1600 GMT)
England have lost to Germany in their last three knockout meetings at major tournaments
Neuer made the squad despite playing in just one official game, a friendly against Austria on Friday, since breaking a bone in his foot in September but talented 22-year-old Sane was the biggest name to miss out.
Scotland's Clarke names uncapped trio in Euro squad.
Flawless Bayern Munich struck twice in three minutes to beat Schalke 04 2-0 on Saturday and stay top of the Bundesliga with four wins from four as rivals Borussia Dortmund lost 3-2 at Hamburg SV to end a 31-match unbeaten run.
Ronaldo had failed to score in his last four league games for Real and his rotten run in front of goal looked set to continue when his spot-kick was turned away by visiting goalkeeper Roberto.
A round-up of Saturday's action in Serie A, La Liga and Bundesliga.
Real Madrid have enviously looked on as Barcelona claimed six La Liga titles in the last eight years, but Zinedine Zidane's side can take a huge step towards a first crown since 2012 with victory over their bitter rivals at the Nou Camp on Saturday.
Bayern Munich continued their astonishing scoring run by demolishing Hertha Berlin 6-0 away on Saturday with Arjen Robben scoring a hat-trick as the Bavarians took their tally to 20 goals in three matches.
Real Madrid forward Karim Benzema has not recovered sufficiently from a knee injury and has been left out of the squad for Tuesday's Champions League semi-final first leg at Juventus, the holders said on Monday.
Serbian midfielder Dusan Tadic said Zinedine Zidane had helped inspire what he described as the game of his life in Ajax Amsterdam's 4-1 drubbing of Champions League holders Real Madrid on Tuesday.
News of all that's transpired on and off the football field
Subdued atmosphere at the Nou Camp after the deadly attacks in the Catalan capital and the town of Cambrils.
Champions League holders Real Madrid will have to work around a string of injuries to key players in a tough match against CSKA Moscow, manager Julen Lopetegui said on Monday.
Striker Mariano's header was glanced onto the crossbar by Sociedad's Andoni Gorosabel while the loose ball fell to Marco Asensio, whose shot was deflected wide for a corner from which Raphael Varane header hit the top of the bar.
Ten-man Bayern Munich opened a six-point advantage at the top of the Bundesliga on Friday, a 3-0 win over Cologne ensuring they will go into the winter break as leaders.
Bayern Munich needed a stoppage-time winner from Bastian Schweinsteiger to beat VfL Wolfsburg 2-1 and successfully kick off their Bundesliga title defence on Friday.
Manchester City marched into the quarter-finals of the Champions League
