English champions and runners-up since the league restarted in the 1946-47 season after World War Two:
The Spaniard has made a number of uncharacteristic mistakes in recent games, including one that allowed Chelsea to equalise in Sunday's 1-1 draw.
Burnley beat Blackburn Rovers 2-0 at Ewood Park in their East Lancashire derby but Premier League sides Southampton and Newcastle United crashed out of the English League Cup to Championship opposition in Wednesday's second-round games.
Chelsea begin their bid to become only the fifth team in 119 years to win a third successive English league title this weekend.
Minor league Lincoln City produced a huge FA Cup shock to beat top-flight Burnley 1-0 and reach the quarter-finals for the first time in their history on Saturday.
Mourinho's tinkerings meant a first start of the season for midfielder Scott McTominay, playing on the right of a three-man defence, while Anthony Martial played instead of the dropped Alexis Sanchez. On this evidence, more changes may be needed when United take on Valencia in the Champions League on Tuesday.
Mohamed Salah was inevitably on the scoresheet as Liverpool took full advantage of the inactivity of their top-four rivals to thrash West Ham United 4-1 at Anfield and provisionally move into second in the Premier League.
The 27-year-old Belgium international had joined City squad last week after helping his country progress to the World Cup semi-finals in Russia.
Chelsea's players must quickly adapt to new manager Maurizio Sarri's demands as the Italian looks to reshape the team for the new Premier League season
Chelsea coach Maurizio Sarri wants to keep Belgian forward Eden Hazard at the Premier League club and improve him as a player.
Arsenal midfielder Aaron Ramsey says he has yet to reach an agreement with the Premier League club about his future. The Wales international, who joined the club in 2008, is in the final year of his contract.
Five talking-points from the Premier League weekend after Manchester City suffered a shock home loss to Crystal Palace, meaning that Liverpool stayed four points clear at the top following their win over Wolverhampton Wanderers.
'It's only 13 games in, that's the most important thing and there's so many points to be won. You need to carry on for 38 games and show consistency'
Rediff.com encapsulates all the sporting action from the past week in this eye-catching photo feature.
The home team's record signing Jefferson Lerma, who cost 25 million pounds ($32 million) in August, scored a spectacular own goal to give Arsenal the lead but Norwegian international Josh King, back in the Bournemouth side after injury, equalised just before halftime.
News of all that's transpired on and off the football field
Following is a match by match look at the English Premier League's weekend fixtures:
Failing to sign Cristiano Ronaldo is outgoing Arsenal manager Arsene Wenger's biggest transfer regret
News of all that's transpired on and off the football field
Leeds United returned to the Premier League after a 16-year absence on Friday as West Bromwich Albion's loss at Huddersfield Town guaranteed them a top-two finish in the Championship. Three times English champions, Leeds were relegated from the Premier League in 2004 after hitting financial trouble and being forced to sell a host of big-name players such as Robbie Keane, Jonathan Woodgate and Lee Bowyer.
West Ham had lost their first three Premier League games to sit bottom of the table and their dismal start to the campaign had already sparked speculation among pundits as to whether new manager Manuel Pellegrini would see out the season.
The FIFA 2022 World Cup will kick-off in Qatar on Sunday, November 20. Here is a list of the 26-man squads playing in the quadrennial global football extravaganza.
Sergio Aguero netted his 13th hat-trick for Manchester City as the champions made light of the absence of the injured Kevin De Bruyne to thrash Huddersfield Town 6-1 and move joint top of the Premier League.
With United unable to sign a replacement, the pressure will be on 21-year-old England forward Marcus Rashford to deliver the goals in a more central role than he has previously operated in.
Romelu Lukaku extended his impressive FA Cup scoring record by netting twice in Manchester United's 2-0 win at Huddersfield Town to earn Jose Mourinho's side a quarter-final tie at home to Brighton & Hove Albion.
Tottenham Hotspur's status as Premier League title chasers was seriously harmed on Saturday as they fell to a first defeat in seven league games, losing the lead to go down 3-1 at home to Wolverhampton Wanderers.
Images from the English Premier League matches played on Saturday.
'I co-operated excellently with him at Chelsea, and the fact that Mourinho is the coach at Manchester was the decisive factor in my choosing my new environment'
Claudio Ranieri will not have to wait long for another job following his sacking by Leicester City, Manchester City manager Pep Guardiola said on Tuesday.
Sevilla coach Vincenzo Montella has suggested that the only way his side will be able to stop Manchester United forward Alexis Sanchez in Wednesday's Champions League last-16 first leg will be to tie the Chilean up with a rope.
Arsenal suffered another painful Premier League defeat as Swansea City capitalised on some glaring errors to win 3-1 on Tuesday, boosting their survival hopes and denting the visitors' top four chances.
Manchester United will travel to third-tier MK Dons in the Capital One Cup second round following the draw on Wednesday, the first time they have been involved at this stage of the competition for 19 years.
League One Burton, managed by Nigel Clough, the son of former Nottingham Forest boss Brian, must endure another 90 minutes at their own ground on Jan. 23 before City formally book their place in the final.
The game at Huddersfield is the first meeting between the clubs since 1972 and the Yorkshire side have not won one since 20 years before that, in March 1952.
'Next season will be better for him, but he is learning how to play with us and we are learning how to get the best out of him'
Jose Mourinho's side have been the most impressive of any of the title contenders.
Arsenal's new manager Unai Emery faces a baptism of fire after the Gunners were handed an opening day fixture at home to Premier League champions Manchester City.
Chelsea to host Burnley in Premier League season ope
Manchester City barely got out of second gear as they easily beat bottom club Huddersfield Town to close the gap on Premier League leaders Liverpool to four points on Sunday.
Images from the English Premier League matches played on Saturday