Mourinho's tinkerings meant a first start of the season for midfielder Scott McTominay, playing on the right of a three-man defence, while Anthony Martial played instead of the dropped Alexis Sanchez. On this evidence, more changes may be needed when United take on Valencia in the Champions League on Tuesday.
Arsenal laboured to their second win of the season with a highly-charged 1-0 victory against 10-man Newcastle United at St James' Park on Saturday.
Arsenal visit Liverpool looking for a first league win at Anfield since 2003. Defeat for Arsene Wenger's side will move seventh-placed Liverpool within a point of them, having played a game more.
A stunning late strike from red-hot Tottenham Hotspur winger Gareth Bale lifted the Londoners to a 3-2 win over West Ham United on Monday that took them up to third in the Premier League table.
West Ham United eased into the quarter-finals of the FA Cup with a 5-1 romp at second-tier Blackburn Rovers on Sunday.
Wenger announced on Friday that he would leave Arsenal at the end of the season, bringing an end to his near 22-year reign at the north London club.
West Ham United vice-chairman Karen Brady says hopes of re-starting the Premier League in three weeks are "dreamland" and believes this season could be declared null and void. England's top-flight soccer league, like the rest of world sport, finds itself in unprecedented peace-time territory as it attempts to react to the coronavirus pandemic which has infected nearly 800 people so far in Britain.
Bournemouth winger Jordan Ibe has suffered no ill-effects from being robbed of an expensive watch at knifepoint recently, according to manager Eddie Howe.
However, one goal proved enough for City who picked up their sixth successive league win to move four points clear of Liverpool, who host Aston Villa later on Saturday, at the top of the standings.
Kane began the night level on 19 goals with Liverpool's Mohamed Salah in the race for the Golden Boot.
Manchester United will exercise their option to extend veteran striker Zlatan Ibrahimovic's contract for a second season at Old Trafford, manager Jose Mourinho said on Wednesday. The 35-year-old Ibrahimovic, who joined on a free transfer in July, has had a mixed start to his United career despite scoring eight goals in 17 games in all competitions. "Zlatan's situation is simple: he has a one-plus-one contract with the club and we will execute the option of a second season," Mourinho told reporters.
The schedule of matches in the English Premier League between Saturday, September 26 and Monday, September 28.
England have cancelled Wednesday's international soccer friendly with the Netherlands at Wembley on police advice as forces focus on dealing with rioting and looting in the capital.
Images from the English Premier League matches played on Sunday
Liverpool cranked up the pressure on West Ham United manager Slaven Bilic with a 4-1 victory at the London Stadium, while Burnley's remarkable start to the Premier League season continued thanks to a 1-0 victory at Southampton on Saturday.
Chelsea ended their slump with a win over Arsenal while seemingly invincible Manchester City lost their 100 per cent record to West Ham United on a day of contrasting fortunes for the Premier League title favourites on Saturday.
Blackpool thwarted a late rally by Birmingham City in a Championship (second division) play-off on Wednesday, drawing 2-2 to clinch a 3-2 aggregate victory and set up a high-stakes final with West Ham United next week.
West Ham United edged closer to a Premier League return with a 3-0 home win over Cardiff City on Monday, completing a 5-0 semi-final aggregate triumph to ease into the Championship (second division) playoff final.
Images from Sunday's Premier League matches.
English soccer club Tottenham Hotspur on Wednesday won legal clearance to challenge a decision to hand the 2012 Olympic stadium to rivals West Ham United after the Games.
Photos from the Premier League matches played on Sunday
Former Chelsea and England midfielder Frank Lampard announced his retirement from professional soccer on Thursday after spending last year with New York City in Major League Soccer in the United States.
West Ham United capitalised on two mistakes from Arsenal's new goalkeeper Petr Cech to claim a surprise 2-0 victory at the Emirates and bring the Gunners' early Premier League optimism down to earth with a bump on Sunday.
Chelsea brushed aside London rivals West Ham United with a 2-1 away win that restored their 10-point lead at the top of the Premier League on Monday.
The Premier League said on Monday that 10 people had returned positive results in its latest round of COVID-19 tests conducted on players and staff last week, the highest number of cases in a single round since the new season began this month.
The strip made a memorable debut in the 7-0 thrashing of Maribor in the Champions League group stage, marking Liverpool's biggest ever away win in European competition.
The win moved Spurs up to third but unbeaten Manchester City still looked in a class of their own at the top as Leroy Sane scored twice in a 4-0 stroll over West Ham United.
West Ham United midfielder Ravel Morrison has admitted an FA charge of "using abusive and/or insulting words" after a homophobic remark on Twitter, the governing body said.
News of all that's transpired on and off the football field
Liverpool appointed Kevin Keen as first team coach on Sunday as part of manager Kenny Dalglish's reorganisation of his backroom staff.
A deal to award preferred bidder status for London's main 2012 Olympic stadium to English soccer club West Ham United has collapsed, according to a BBC report on Tuesday.
Leicester City manager Claudio Ranieri has been named the Premier League manager of the month for March, while Tottenham Hotspur striker Harry Kane has won the players' award.
Champions Chelsea begin title defence at home to Swansea City, while runners-up Manchester City kick-off at West Bromwich Albion
Chelsea exploited Manchester City's decision to field a weakened team by romping to a 5-1 win in the FA Cup fifth round on Sunday as they joined London rivals West Ham United and Crystal Palace in the quarter-finals.
West Ham United will know later on Friday whether Andy Carroll will have to complete a three-match suspension after the English FA agreed to an arbitration hearing following a failed appeal against his red card in a Premier League match last week.
West Ham United striker Carlton Cole has been fined 20,000 pounds ($32,790) for Twitter comments made during England's friendly against Ghana at Wembley last month, the Football Association said on Wednesday.
Manchester United eased the pressure on manager Ole Gunnar Solskjaer with a 3-1 win at Everton in the Premier League on Saturday with Bruno Fernandes scoring twice and Edinson Cavani grabbing his first for the club.
Following is a match by match look at the English Premier League's weekend fixtures
Chelsea's terrible start to the season plumbed new depths on Saturday when the Premier League champions lost 2-1 at West Ham United.
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