The world rapid champion Humpy got the better of Russian 6-5 to set up a last four clash with world No.1 Hou Yifan of China.
The Grand Prix consists of four legs, with a total of 21 participants. Each of the 21 players participates in three out of four Grand Prix legs. Each GP is a 16-player knockout event.
Humpy, the world rapid champion, overcame her Chinese opponent in a close match with the Indian winning the decisive bullet game.
Vaishali fell behind early and could not catch up against Gunina, who had finished runner-up in the first leg.
Young Indian Grandmaster Vaishali Rameshbabu's fine run in the first leg of FIDE chess.com Women Speed Chess Championships ended on Friday with a defeat in the semi-finals at the hands of Anna Ushenina of Ukraine. The 19-year-old Chennai player went down 4.5-5.5 to the experienced Ukrainian GM in an exciting last four clash of the online tournament.
Vaishali came back from 2-4 down to oust the experienced Ukrainian by winning the last two bullet games.
Young Indian Grandmaster Vaishali Rameshbabu on Thursday beat International Master Munkhzul Turmunkh of Mongolia to storm into the semi-finals of the first leg of FIDE chess.com Women Speed Chess Championships but the country's top player Koneru Humpy bowed out in the opener.
Humpy was no match for Alexandra Kosteniuk of Russia, going down 2-9 while Harika was ousted by world No.1 Hou Yifan of China
World No.1 Hou Yifan defeated Sarasadat Khademalsharieh of Iran 7.5-2.5 to finish third.
An overview of India's underwhelming performance in athletics